Dr. Thomas Ala

• Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ (2002) The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer's disease. Int J Ger Psychiatry 17, 503-509.
• Ala TA, Doss RC, Sullivan CJ (2004) Reversible dementia. A case of cryptococcal meningitis masquerading as Alzheimer’s disease. J Alzheimers Dis 6, 503-508.
• Ala T. (2004) With difficult patients, a less definitive diagnosis can be helpful. (Guest Editorial). Am J Alzheimers Dis Other Demen 19, 79-80.
• Ala TA, Berck LG, Popovich AM (2005) Using the telephone to call for help and caregiver awareness in Alzheimer disease. Alzheimer Dis Assoc Disord 19, 79-84.

Craig S. Atwood, Ph.D.

• Bowen RL, Verdile G, Liu T, Perry G, Smith MA, Martins RN, Atwood CS (2004) Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-ß protein precursor and amyloid-ß deposition. J Biol Chem 279, 20539-20545.
• Liu T, Perry G, Chan HW, Verdile G, Martins RN, Smith MA, Atwood CS (2004) Amyloid-ß-induced toxicity of primary neurons is dependent upon differentiation associated increases in tau and cyclin-dependent kinase 5. J Neurochem 88, 554-563.
• Wilson, A.C., Salamat, S., Haasl, R.J., Roche, K.M., Karande, A., Vadakkadath Meethal, S., Terasawa, E., Bowen, R.L. and Atwood, C.S. (2006). Human extra-pituitary neurons possess GnRH I receptors that respond to GnRH by expressing luteinizing hormone. J Endocrinol 191, 651-665.
• Porayette, P., Gallego, M.J., Kaltcheva, M.M., Vadakkadath Meethal, S. and Atwood, C.S. (2007). Amyloid-ß precursor protein expression and modulation in human embryonic stem cells: A novel role for human chorionic gonadotropin. Biochem Biophys Res Commun 364, 522-527.

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Jesús Ávila

• Perez M, Santa-María I, Tortosa E, Cuadros R, Del Valle M, Hernández F, Moreno FJ, Avila J (2007) The role of the VQIVYK peptide in tau protein phosphorylation. J Neurochem 103, 1447-1460.
• Goñi-Oliver P, Lucas JJ, Avila J, Hernández F (2007)  N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation. J Biol Chem 282, 22406-22413.
• Gómez-Sintes R, Hernández F, Bortolozzi A, Artigas F, Avila J, Zaratin P, Gotteland JP, Lucas JJ (2007) Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26, 2743-2754.
• Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S (2007) Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. Eur J Neurosci 25, 81-86.

Thomas Bayer, Ph.D.

• Bayer TA , Schäfer S, Simons A, Kemmling, Kamer T, Tepest R, Eckert A, Schüssel K, Eikenberg O, Sturchler-Pierrat, Abramowski D, Staufenbiel, Multhaup G (2003) Dietary Cu stabilizes brain SOD-1 activity and reduces amyloid Aß production in APP23 transgenic mice. PNAS 100, 14187-14192.
• Schmitz C, Rutten BPF, Pielen A, Schäfer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Korr H, Steinbusch HWM, Pradier L, Bayer TA (2004) Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol 164, 1495-1502.
• Wirths O, Czech C, Feldmann F, Blanchard V, Tremp G, Multhaup G, Beyreuther K, Pradier L, Bayer TA (2002) Intraneuronal APP/Abeta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathol 12, 275-286.
• Wirths O, Multhaup G, Bayer TA (2004) A modified ß-amyloid hypothesis: intraneuronal accumulation of the ß-amyloid peptide  The first step in a fatal cascade. J Neurochem 91, 513-520.

Angelika Bierhaus, Ph.D.

• Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert P, Chen J, Hong M, Luther T, Henle T, Klöting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith MA, Perry G, Schmidt AM, Stern DM, Häring HU, Schleicher E, Nawroth PP (2001) Diabetes-associated sustained activation of the transcription factor NF-kB. Diabetes 50, 2792-2809.
• Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, Ferstl R, von Eynatten M, Wendt Th, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwen B, Kirschbaum C, Nawroth PP (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci 100, 1920-1925.
• Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider J, Schulz J, Heuss D, Neundörfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Häring HU, Schleicher E, Stern DM, Kasper M, Arnold B, Nawroth PP (2004) Loss of pain perception in diabetic neuropathy is dependent on a receptor of the immune globulin superfamily. J Clin Invest 114, 1741- 1751.
• Bierhaus A, Nawroth PP (2005) Posttranslational modification of lipoproteins - a fatal attraction in metabolic diseases? J Alzheimers Dis 7, 315-317.

Garth Bissette, Ph.D.

• Bissette G, Smith WH, Dole KC, Crain B, Ghanbari H, Miller B, Nemeroff CB (1991) Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex. Arch Gen Psychiatry 48, 1009-1012.
• Slotkin TA, Nemeroff CB, Bissette G, Seidler FJ (1994) Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's Disease: Evidence from rapid autopsy studies. J Clin Invest 94, 696-702.
• Bissette G, Cook L, Smith W, Dole KC, Crain B, Nemeroff CB (1998) Regional neuropeptide pathology in Alzheimer’s disease: Corticotropin-releasing factor and Somatostatin. J Alzheimers Dis 1, 91-105.
• Horgan J, Miguel-Hidalgo J, Thrasher M, Bissette G (2007) Longitudinal brain corticotropin-releasing factor and ssomatostatin in a transgenic mouse (Tg2576) model of Alzheimers disease. J Alzheimers Dis 12, 115-127.

Professor Alexander Boldyrev

• Boldyrev A, Johnson P (2002) Histidine containing dipeptides as natiral protectors against oxidative stress. In: Oxidative Stress at Molecular, Cellular and Organ Levels. Johnson P, Boldyrev A, Eds., 101-113.
• Boldyrev A, Bulygina E, Carpenter D, Schoner W (2003) Glutamate receptors communicate with Na/K-ATPase in rat cerebellum granule cells. J Mol Neurosci 21, 213-222.
• Boldyrev A, Kazey V, Leinsooa T, Mashkina A, Tyulina O, Johnson P, Tuneva J, Chittur S, Carpenter D (2004) Rodent lymphocytes express functionally active glutamate receptors. Biochem Biophys Res Commun 324, 133-139.
• Boldyrev A, Beresov T, Koudinov A, Carpenter D (2004) Amyloid ß induced cell death is independent of free radicals. J Alzheimers Dis 6, 584-589.

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D. Allan Butterfield, Ph.D.

• Butterfield DA, Poon HF, St. Clair D, Keller JN, Pierce WM, Klein JB, Markesbery WR (2006) Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease. Neurobiol Dis 22, 223-232.
• Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA (2006) Oxidative modification and down-regulation of Pin 1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol Aging 27, 918-925.
• Butterfield DA, Reed T, Newman SF, Sultana R (2007) Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med 43, 658-677.
• Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA (2008) Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging 29, 51-70.

Cynthia M. Carlsson, MD, MS

• Carlsson CM, Gleason CE, Asthana S (2005) Alzheimer disease: Update on diagnosis and treatment. Consultant 45, 77-88.
• Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC (2005) The effect of body mass index on global brain volume in middle-aged adults: a cross-sectional study. BMC Neurology 5, 23.
• Johnson SC, Schmitz TW, Trivedi MA, Ries ML, Torgerson BM, Carlsson CM, Asthana S, Hermann BP, Sager MA (2006) The influence of AD family history and ApoE4 on mesial temporal    lobe activation. J Neurosci 26, 6069-6076.
• Johnson SC, Ries ML, Hess TM, Carlsson CM, Gleason CE, Alexander AL, Rowley HA, Asthana S, Sager MA (2007) Alzheimer disease risk in healthy middle-aged adults affects brain function during self appraisal. Arch Gen Psychiatry 64, 1163-1171.

David O. Carpenter, M.D.

• Tan Y, Chen C-H, Lawrence D, Carpenter DO (2004) Ortho-substituted PCBs kill cells by altering membrane structure. Toxicol Sci 80, 54-59.
• Tan Y, Song R, Lawrence D, Carpenter DO (2004) Ortho-substituted but not coplanar PCBs rapidly kill cerebellular granule cells. Toxicol Sci 79, 147-156.
• Boldyrev AA, Koudinov A, Berezov T, Carpenter DO (2004) Amyloid-β induced cell death is independent of free radicals. J Alzheimers Dis 6, 633-638.
• Tuneva J, Chittur S, Boldyrev AA, Birman I, Carpenter DO (2006) Cerebellar granule cell death induced by aluminum. Neurotox Res 9, 297-304.

Rudy J. Castellani, M.D.

• Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA (2007) Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Rev Neurother 7, 473-485.
• Castellani RJ, Honda K, Moreira PI, Liu Q, Siedlak SL, Zhu X, Smith MA, Perry G (2007) Redox active iron at the center of oxidative stress in Alzheimer disease. Neurochem Res 32, 1640-1645.
• Castellani RJ, Marlatt M, Webber KM, Moreira PI, Lee H, Casadesus G, Honda K,  Zhu X, Perry G, Smith MA (2008) Thinking outside the box in Alzheimer disease treatment. In Development of Therapeutic Agents, Gad S (Ed), John Wiley and Sons, in press.
• Castellani RJ, Lee H, Zhu X, Nunomura A, Perry G, Smith MA (2008) Alzheimer’s disease: pathology vs. etiology. Int J Neuroprot Neuroregen, in press.

Ved Chauhan, Ph.D.

• Chauhan, VPS, Chauhan A, Wegiel J (2001) Fibrillar amyloid beta-protein forms a membrane-like hydrophobic domain. NeuroReport 3, 587-590.
• Chauhan V, Sheikh AM, Chauhan A, Spivack WD, Fenko MD, Malik MN (2005) Fibrillar amyloid beta-protein inhibits the activity of high molecular weight protease, and trypsin. J Alzheimers Dis 7, 37-44.
• Chander H, Chauhan A, Wegiel J, Malik M, Sheikh A, Chauhan V (2006) Binding of trypsin to fibrillar amyloid beta-protein. Brain Res 1082, 173-181.
• Chauhan V, Chauhan A (2006) Oxidative stress in Alzheimer's disease. Pathophysiology 13, 195-208.

Muhammad Omar Chohan, M.D.

• Chohan MO, Haque N, Alonso A, El-Akkad E, Grundke-Iqbal I, Grover A, Iqbal K (2005) Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau. J Neural Transm 112, 1035-1047.
• Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta 1739, 198-210.
• Chohan MO, Iqbal K (2005) Estrogens for the Brain. Alzheimer Research Forum, July 28, 2005, http://www.alzforum.org/pap/annotation.asp?powID=45893.
• Chohan MO, Khatoon S, Grundke-Iqbal I, Iqbal K (2006) Involvement of I2pp2a in the abnormal hyperphosphorylation of tau and its reversal by memantine. FEBS Lett 580, 3973-3979.

Dr. James R. Connor

• Zecca L, Youdim MBH, Riederer P, Connor JR, Crichton RR (2004) Iron, brain aging and neurodegenerative disorders. Nature Rev Neurosci 5, 863-873.
• Lee S, Connor JR (2006)Regulation of Hfe by stress factors in BV-2 cells. Neurobiol Aging 26, 803-812.
• Connor JR, Lee SY (2006) HFE mutations and Alzheimer’s Disease. J Alzheimers Dis 10, 267-276.
• House MJ, St. Pierre TG, Kowdley K, Montine T, Connor JR, Beard J, Siddaiah N, Berger J, Shankland E, Jin LW (2007) Correlation of proton transverse relaxation rates (r2) with Iron concentrations in post-mortem brain tissue from Alzheimer’s disease patients. Magnet Reson Med 57, 172-180.

Dr. Eliecer Coto Garcia

• Alvarez V, Mata IF, González P, Lahoz CH, Martínez C, Peña J, Guisasola LM, Coto E (2002) Association between the TNFα-308 A/G polymorphism and the onset-age of Alzheimer disease. Am J Med Genet 114, 574-577.
• Huerta C, Alvarez V, Mata IF, Coto E, Ribacoba R, Martínez C, Blázquez M, Guisasola LM, Salvador C, Lahoz CH, Peña J (2004) Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease. Neurosci Lett 370, 151-154.
• Huerta C, Castro MG, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Martínez C, Lahoz CH, Alvarez V (2005) Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population. J Neurol Sci 236, 49-54.
• González P, Alvarez V, Menéndez M, Lahoz CH, Martínez C, Corao AI, Calatayud MT, Peña J, García-Castro M, Coto E (2007) Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms. Neurosci Lett 411, 47-51.

Peter Davies, Ph.D.

• Andorfer CA, Acker CM, Kress Y, Hof PR, Duff K, Davies P (2005) Cell cycle re-entry and cell death In transgenic mice expressing non-mutant human tau isoforms. J Neurosci 25, 5446-5454.
• de Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segala S, Rusinek H, Lia J, Tsui W, Saint Louis LA, Clark CM, Tarshish C, Lia Y, Lair L, Javier E, Rich K. Lesbre P. Mosconi L. Reisberg B. Sadowski M. DeBernadis JF. Kerkman DJ. Hampel H. Wahlund L-O. Davies P (2006) Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging 27, 394-401.
• d'Abramo C, Ricciarelli R, Pronzato MA, Davies P (2006) Troglitazone, a Poroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells. J Neurochem 98, 1068-1077.
• Park KHJ, Hallows JL, Chakrabarty P, Davies P, Vincent I (2007) Conditional neuronal SV40 T Antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci 27 2969-2978.

Suzanne de la Monte, M.D.,M.P.H.

• Etiene D, Kraft J, Ganju N, Gomez-Isla T, Gemelli B, Hyman BT, Hedley-Whyte ET, Wands JR, De La Monte SM (1998) Cerebrovascular pathology contributes to the heterogeneity of Alzheimer's disease. J Alzheimers Dis 1, 119-134.
• de la Monte SM, Wands JR (2001) The AD7c-NTP neuronal thread protein biomarker for detecting Alzheimer's disease. J Alzheimers Dis 3, 345-353.
• de la Monte SM, Chiche J, von dem Bussche A, Sanyal S, Lahousse SA, Janssens SP, Bloch KD (2003) Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration. Lab Invest 83, 287-298.
• de la Monte SM, Tong M, Lester-Coll N, Plater M Jr, Wands JR (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J Alzheimers Dis 10, 89-109.

Jack C. de la Torre, M.D., Ph.D.

• de la Torre JC (Ed) (2006) Special Issue: Impact of Heart Disease and Stroke on Alzheimer’s Disease. Neurol Res 28(6).
• Obrenovich ME, Siedlak SL, Smith MA, Chen S, de la Torre JC, Perry G, Aliev G (2006) Overexpression of GRK2 in Alzheimer disease and in a chronic hyperperfusion rat model is an early marker of brain mitochondrial lesion. Neurotox Res 10, 43-56.
• de la Torre JC (2007) Vascular pathways to Alzheimer’s disease. Dementia Forum 2, 2-6.
• de la Torre JC (2008) Pathophysiology of neuronal energy crisis in  Alzheimer’s disease. Neurodegenerative Dis 5, 126-132.

Alexandre Valério de Mendonça

• Rebola N, Sebastião AM, de Mendonça A, Ribeiro JA, Oliveira CR, Cunha RA (2003) Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. J Neurophysiol 90, 1295-1303.
• Rebola N, Coelho JE, Costenla AR, Lopes LV, Parada A, Oliveira CR, Soares da Silva P, de Mendonça A, Cunha RA (2003) Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. Eur J Neurosci 18, 820-828.
• Almeida T, Rodrigues RJ, de Mendonça A, Ribeiro JA, Cunha RA (2003) Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Neuroscience 122, 111-121.
• de Mendonça A, Guerreiro M, Ribeiro F, Mendes T, Garcia C (2004) Mild cognitive impairment: focus on the diagnosis. J Mol Neurosci 23, 13-17.

Dr. Justo Garcia de Yebenes

• Gomez-Tortosa E, Gonzalo I, Fanjul S, Sainz MJ, Cantarero S, Cemillan C, Yebenes JG, del Ser T (2003) Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease. Arch Neurol 60, 1218-1222.
• Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, Llorens V, Gomez Tortosa E, del Ser T, Munoz DG, de Yebenes JG (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55, 164-173.
• Ros R, Thobois S, Streichenberger N, Kopp N, Sanchez MP, Perez M, Hoenicka J, Avila J, Honnorat J, de Yebenes JG (2005) A new mutation of the {tau} gene, G303V, in early-onset familial progressive supranuclear palsy. Arch Neurol 62, 1444-1450.
• Menenedez J, Rodriguez rroJA, Solano RM, Casarejos MJ, Rodal I, Guerrero R, Sanchez M, Avila J, Mena MA, de Yebenes JG (2006) Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau. Human Mol Genet 15, 2045-2058.

Sara M. Debanne, Ph.D.

• Petot GJ, Traore F, Debanne SM, Lerner AJ, Friedland RP (2003) Interactions of Apolipoprotein E Genotype and Dietary Fat Intake of Healthy Older Persons During Mid-Adult Life. Metabolism 52, 279-281.
• Mizrahi EH, Jacobsen DW, Debanne SM, Traore F, Lerner AJ, Friedland RP, Petot GJ (2003) Plasma Total Homocysteine  Levels, Dietary Vitamin B6 and Folate Intake in AD and Healthy Aging. J Nutrition Health Aging 7, 160-165.
• Lindstrom HA, Fritsch T, Petot G, Smyth KA, Chen CH, Debanne SM, Lerner AJ, Friedland RP (2005) The relationships between television viewing in midlife and the development of Alzheimer disease in a case-control study. Brain Cogn 58, 157-165.
• Debanne SM, Bielefeld RA, Cheruvu V, Fritsch T, Rowland DY (2007) Association of Alzheimer Disease and Smoking: Bias in Cohort Studies. J Alzheimers Dis 11, 313-321.

Jon Dobson, Ph.D.

• Hautot D Pankhurst QA, Kahn N, Dobson J (2003) Preliminary evaluation of nanoscale biogenic magnetite and Alzheimer's disease. Proc Royal Soc B Biol Lett 270, S62-S64.

• Collingwood JF, Mikhailova A, Davidson M, Batich C, Streit WJ, Terry J, Dobson J (2005) In-situ characterization and mapping of iron compounds in Alzheimer's tissue. J Alzheimers Dis 7, 267-272.
• Khan A, Dobson J, Exley C (2006) The redox cycling of Fe(II) by Aβ42. Free Radic Biol Med 40, 557-569.
• Collingwood JF, Dobson J (2006) Mapping and characterization of iron compounds in Alzheimer's tissue. J Alzheimers Dis 10, 215-222.

Peter R. Dodd, Ph.D.

• Tsai VW-W, Scott HL, Lewis RJ, Dodd PR (2005) The role of Group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease. Neurotox Res 7, 125-141.
• Tannenberg RK, Scott HL, Tannenberg AEG, Dodd PR (2006) Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE µ4. Neurochem Int 49, 631-639.
• Walton HS, Dodd PR (2007) Glutamate-glutamine cycling in Alzheimer's disease. Neurochem Int 50, 1052-1066.
• Agarwal S, Tannenberg RK, Dodd PR (2008) Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer disease. J Alzheimers Dis, in press.

Dr. Valeria Drago

• Drago V, Foster PS, Trifiletti D, FitzGerald DB, Crucian GP, Heilman KM (2006) "What's Inside the Art?" The influence of fronto-temporal dementia in art production. Neurology 67, 1285-1287.
• Drago V, Grucian GP, Pisani F, Heilman KM (2006) Distribution of attention as a Function of spatial location: right left; up-down. J Int Neuropsychol Soc 12, 532-537.
• Drago V, Foster FS, Ferri R, Arico D, Heilman KM (2008) Distractibility and Alzheimer disease. The "neglected" phenomenon. J Alzheimers Dis, in press.

Professor Murat Emre

• Lippa CF, Emre M (2006) Characterizing clinical phenotypes: the Lewys in their life or the life of their Lewys? Neurology 67, 1910-1911.
• Sahin HA, Emre M, Ziabreva I, Perry E, Celasun B, Perry R (2006) The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol (Berl) 111, 115-125.
• Sahin HA, Gurvit IH, Emre M, Hanagasi HA, Bilgic B, Harmanci H (2006) The attitude of elderly lay people towards the symptoms of dementia. Int Psychogeriatr 18, 251-258.
• Aarsland D, Bronnick K, Ehrt U, De Deyn PP, Tekin S, Emre M, Cummings JL (2007) Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry 78, 36-42.

Adnan Erol, M.D.

• Erol A (2007) Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress. Bioessays 29, 811-818.
• Erol A (2007) Interleukin-6 (IL-6) is still the leading biomarker of the metabolic and aging related disorders. Med Hypotheses 69, 708.
• Erol A (2007) The functions of PPARs in aging and longevity. PPAR Res, doi:10.1155/2007/39654.
• Erol A (2008) An integrated and unifying hypothesis for the metabolic basis of sporadic Alzheimer’s disease. J Alzheimers Dis  13, 241-253.

Dr. Christopher Exley

• Exley C, Korchazhkina O, Job D, Strekopytov S, Polwart A & Crome P (2006) Non-invasive therapy to reduce the body burden of aluminium in Alzheimer’s disease. J Alzheimers Dis 10, 17-24.
• Exley C (2006) Aluminium and iron, but neither copper nor zinc, are key to the precipitation of β-sheets of Aβ42 in senile plaque cores in Alzheimer’s disease. J Alzheimers Dis 10, 173-177.
• Exley C, Esiri M (2006) Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK. J Neurol Neurosurg Psychiatr 77, 877-879.
• Khan A, Dobson J, Exley C (2006) The redox cycling of iron by Aβ42. Free Radic Biol Med 40, 557-569.

Milan Fiala, M.D.

• Fiala M, Lin J, Kermani-Arab V, Ringman J, Gustavson A, Sayre J, Lossinsky AS, Sofroni E, Graves MC, Chiappelli F, Bernard G (2005) Defective phagocytosis of amyloid-β by macrophages of Alzheimer’s disease patients. J Alzheimers Dis 7, 221-232.
• Zhang L, Fiala M, Sayre J, Espinosa A, Mahanian M, Badmaev V, Graves M, Bernard G (2006) Curcuminoids enhance phagocytosis of amyloid-beta by macrophages of Alzheimer’s disease patients. J Alzheimers Dis 10, 1-7.
• Fiala M, Cribbs DH, Rosenthal M, Bernard G (2007) Phagocytosis of amyloid-β and inflammation: two faces of innate immunity in Alzheimer’s disease. J Alzheimers Dis 11, 1-7.
• Fiala M, Liu P, Espinosa-Jeffrey A, Rosenthal M, Ringman J, Sayre J, Zhang L, Zaghi J, Chiang B, Dejbakhsh S, Hui J, Mahanian M, Bernard G, Cashman J (2007) Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci (USA) 104, 12849-12854.

Vincenzo Fodale, M.D

• Fodale V, Quattrone D, Trecroci C, Caminiti V, Santamaria LB (2006) Alzheimer's disease and anaesthesia: implications for the central cholinergic system. Br J Anaesth 97, 445-452.
• Fodale V, Mafrica F, Caminiti V, Grasso G (2006) The cholinergic system in Down's syndrome. J Intellect Disabil 10, 261-274.
• Grasso G, Sfacteria A, Meli F, Passalacqua M, Fodale V, Buemi M, Giambartino F, Iacopino DG, Tomasello F (2007) The role of erythropoietin in neuroprotection: therapeutic perspectives. Drug News Perspect 20, 315-320.
• Mafrica F, Fodale V (2008) Thyroid function, Alzheimer’s disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? J Alzheimers Dis, in press.

Prof. Francisco García-Sierra

• Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI, Cryns VL (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer’s disease. Proc Natl Acad Sci U S A 100, 10032-10037.
• Basurto-Islas G, Luna-Muñoz J, Guillozet-Bongaarts AL, Binder LI, Mena R, García-Sierra F (2008) Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. J Neuropathol Exp Neurol 67, 470-483.
• Mondragón-Rodríguez S, Basurto-Islas G, Santa-Maria I, Mena R, Binder LI, Avila J, Smith MA, Perry G, García-Sierra F (2008) Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease. Int J Exp Pathol 89, 81-90.
• Mondragón-Rodríguez S, Mena R, Binder LI, Smith MA, Perry G, García-Sierra F (2008) Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology. Neuropathol Appl Neurobiol 34, 62-75.

Dr. Othman Ghribi

• Ghribi O, Herman MM, Forbes MS, DeWitt DA, Savory J (2001) GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation. Neurobiol Dis 8, 764-773.
• Ghribi O, Herman MM, Pramoonjago P, Savory J (2003) MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATF-6 and NF-kappaB signaling pathways. J Neuropathol Exp Neurol 62, 1144-1153.
• Ghribi O, Larsen B, Schrag M, Herman MM (2006) High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol 200, 460-467.
• Ghribi O, Golovko MY, Larsen B, Schrag M, Murphy EJ (2006) Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. J Neurochem 99, 438-449.

Cheng-Xin Gong, M.D.

• Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong C-X (2004) O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease. Proc Natl Acad Sci USA 101, 10804-10809.
• Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong C-X (2005) Dephosphorylation of tau by protein phosphatase 5: Impairment in Alzheimer disease. J Biol Chem 280, 1790-1796.
• Liang Z, Liu F, Grundke-Iqbal I, Iqbal K, Gong C-X (2007) Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J Neurochem 103, 2462-2470.
• Deng Y, Li B, Liu F, Iqbal K, Grundke-Iqbal I, Brandt R, Gong C-X (2008) Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. FASEB J 22, 138-145.

Prof. Jürgen Götz

• Götz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta42 fibrils. Science 293, 1491-1495.
• Götz J, Streffer JR, David D, Schild A, Hoerndli F, Pennanen L, Kurosinski P, Chen F (2004) Transgenic animal models of Alzheimer’s disease and related disorders: Histopathology, behavior and therapy. Mol Psychiatr 9, 664-683.
• Chen F, Wollmer A, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J (2004) Role for glyoxalase I in Alzheimer’s disease. Proc Natl Acad Sci USA 101, 7687-7692.
• David DC, Ittner LM, Gehrig P, Nergenau D, Shepherd C, Halliday G, Götz J (2006) β-Amyloid treatment of two complementary P301L tau-expressing Alzheimer’s disease models reveals similar deregulated cellular processes. Proteomics 6, 6566-6577.

John L. Goudreau, D.O., Ph.D.

• Goudreau JL, Maraganore DM, Farrer MJ, Lesnick TG, Singleton AB, Hardy JA, Rocca WA (2002) Case-control study of dopamine transporter-1, monoamine oxidase-B and catechol-O-methyl transferase polymorphisms in Parkinson’s disease. Move Disord 17, 1305-1311.
• Drolet RD, Behrouz B, Lookingland KJ, Goudreau JL (2006) Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of α-synuclein. J Neurochem 96, 950-959, 2006.
• Duka T, Rusnak M, Drolet RE, Duka V, Wersinger C, Goudreau JL, Sidu A (2006) Alpha-synuclein induces the hyperphosphorylation of tau in the MPTP model of parkinsonism. FASEB J 20, 2302-2312.
• Behrouz D, Drolet RE, Sayed ZA, Lookingland KJ, Goudreau JL (2007) Unique responses to mitochondrial complex I inhibition in tuberoinfundibular dopamine neurons may impart resistance to toxic insult. Neuroscience 147, 592-598.

Prof. Stefano Govoni

• Lanni C, Uberti D, Racchi M, Govoni S, Memo M (2007) Unfolded p53: a potential biomarker for Alzheimer's disease. J Alzheimers Dis 12, 93-99.
• Lenzken SC, Lanni C, Govoni S, Lucchelli A, Schettini G, Racchi M (2007) Nicotinic component of galantamine in the regulation of amyloid precursor protein processing. Chem Biol Interact 165, 138-145.
• Lanni C, Racchi M, Mazzini G, Ranzenigo A, Polotti R, Sinforiani E, Olivari L, Barcikowska M, Styczynska M, Kuznicki J, Szybinska A, Govoni S, Memo M, Uberti D (2007) Conformationally altered p53: a novel Alzheimer's disease marker? Mol Psychiatry, in press.
• Preda S, Govoni S, Lanni C, Racchi M, Mura E, Grilli M, Marchi M (2007) Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens. Neuropsychopharmacology, in press.

Paula Grammas, Ph.D.

• Hensley K, Ferrell S, Floyd RA, Gordon B, Grammas P, Mhatre M, Mou S, Pye QN, Stewart C, West M, West S, Williamson KS (2004) The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits TNFa activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem 91, 540-546.
• Christov A, Ottman JT, Grammas P (2004) Vascular inflammatory, oxidative and protease-based proceses: implication neuronal cell death in Alzheimer’s disease. Neurol Res 26, 540-546.
• Kanmogne GD, Primeaux C, Grammas P (2005) HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: Implications for the pathogenesis of HIV-associated dementia. J Neuropathol Exp Neurol 64, 498-505.
• Kanmogne GD, Primeaux C, Grammas P (2005) Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins. Biochem Biophys Res Commun 333, 1107-1115.

Dr. Ann-Charlotte Granholm

• Isacson O, Seo H, Lin L, Albeck D, Granholm AC (2002) Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25, 79-84.
• Hunter CL, Bachman D, Granholm AC (2004) Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Ann Neurol 56, 675-688.
• Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE (2004) Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets 5, 517-528.
• Williams BJ, Eriksdotter-Jonhagen M, Granholm AC (2006) Nerve growth factor in treatment and pathogenesis of Alzheimer's disease. Prog Neurobiol 80, 114-128.

Dr. Edna Grünblatt

• Grünblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101, 757-770.
• Grünblatt E, Zander N, Bartl J, Jie L, Monoranu C.M, Arzberger T, Rivka R, Roggendorf W, Gerlach M, Riederer P (2007) Comparison analysis of gene expression patterns between sporadic Alzheimer's and Parkinson's disease. J Alzheimer Dis 12, 291-311.
• Monoranu CM, Apfelbacher M, Grünblatt E, Puppe B, Alafuzoff I, Ferrer I, Al-Saraj S, Keyvani K, Schmitt A, Falkai P, Schittenhelm J, Halliday G, Kril J, Harper C, Riederer P, Roggendorf W (2008) pH measurement as quality control on human postmortem brain tissue: A Study of the Brain Net Europe Consortium. Neuropath Appl Neurobiol, in press.
• Grünblatt E, Zehetmayer S, Bartl J, Löffler C, Wichart I, Rainer MK, Jungwirth S, Bauer P, Danielczyk W, Tragl KH, Riederer P, Fischer P (2008) Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study. J Psych Res, in press.

Sanna-Kaisa Herukka

• Herukka SK, Hallikainen M, Soininen H, Pirttilä T (2005) CSF Abeta and Tau or phosphorylated Tau and prediction of progressive mild cognitive impairment. Neurology 64, 1294-1297.
• Herukka SK, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T (2007) CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI. Neurobiol Aging 28, 507-514.
• Lämsä R, Helisalmi S, Herukka SK, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H (2008) Genetic study evaluating LDLR polymorphisms and Alzheimer's disease. Neurobiol Aging, in press.
• Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Helisalmi S, Pirttilä T (2008) Expression of interleukin 18 is increased in the brain of Alzheimer’s disease patients. Neurobiol Aging, in press.

Prof. Nigel M. Hooper

• Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ (2003) Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci USA 100, 11735-11740.
• Vardy ERLC, Catto AJ, Hooper NM (2005) Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med 11, 464-472.
• Cordy JM, Hooper NM, Turner AJ (2006) The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol 23, 111-122.
• Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper HM (2007) Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci USA 104, 11062-11067.

Khalid Iqbal, Ph.D.

• Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I (2005) Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Ann Neurol 58, 748-757.
• Wang JZ, Grundke-Iqbal I, Iqbal K (2007) Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci 25, 59-68.
• Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I (2007) Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogeneis. Neurobiol Aging 28, 1148-1162.
• Chen S, Li B, Grundke-Iqbal I, Iqbal K (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit or protein phosphatase 2A. J Biol Chem 283, 10513-10521.

Michael C. Irizarry, M.D., M.P.H.

• Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC (2004)  Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62, 925-931.
• Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology 65, 1402-1408.
• Irizarry MC, Yao Y, Hyman BT, Growdon JH, Praticò D (2007) Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease. Neurodegener Dis 4, 403-405.
• Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung GY, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I, Matthews PM, Owen MJ, Plumpton M, Pryse-Phillips W, Prinjha RK, Richardson JC, Saunders A, Slater AJ, St George-Hyslop PH, Stinnett SW, Swartz JE, Taylor RL, Wherrett J, Williams J, Yarnall DP, Gibson RA, Irizarry MC, Middleton LT, Roses AD (2008) Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol 65, 45-53.

Prof. Ruth Itzhaki

• Wozniak MA, Combrinc M, Wilcock GK, Itzhaki RF (2005) Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients. J Med Virol 75, 300-306.
• Itzhaki RF, Wozniak MA (2006) Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer’s disease and other disorders. Progr Lipid Res 45, 73-90.
• Wozniak MA, Shipley SJ, Dobson CB, Parker SP, Scott FT, Leedham-Green M, Breuer J, Itzhaki RF,  (2007) Does apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus? Eur J Human Genet 15, 672-678.
• Wozniak MA, Shipley SJ, Itzhaki RF, Dobson CB (2007) Herpes virus-induced amyloid deposition: a major pathway to Alzheimer’s disease. Neurosci Lett. In proof: doi:10.1016/j.neulet.2007.09.077.

Christian P. Jacob, M.D.

• Jacob C, Strobel A, Hohenberger K, Ringel T, Gutknecht L, Reif A, Brocke B, Lesch KP (2004) Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders. Am J Psychiatry 161, 569-572.
• Jacob C, Muller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, Schmidtke A, Mossner R, Lesch KP (2005) Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology 30, 1711-1718.
• Gutknecht L*, Jacob C*, Strobel A*, Müller J, Reif A, Mössner R, Zeng Y, Gross C, Brocke B, Lesch KP (2007) Tryptophan hydroxylase-2 gene variation influences personality traits and related disorders. Int J Neuropsychopharmacol 10, 309-320. *contributed as equal.
• Jacob C, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P, Grünblatt E (2007) Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer’s disease. J Alzheimers Dis 11, 97-116.

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Kurt A. Jellinger, M.D.

• Jellinger KA (2006) Clinicopathological analysis of dementia disorders in the elderly--an update. J Alzheimers Dis 9, 61-70.
• Jellinger KA (2007) More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains. Acta Neuropathol (Berl) 114, 299-303.
• Jellinger KA, Attems J (2007) Neuropathological evaluation of mixed dementia. J Neurol Sci 257, 80-87.
• Jellinger KA, Attems J (2007) Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathol 113, 107-117.

Tae H. Ji

• Hone E, Martins IJ, Jeoung M, Ji TH, Grandy SE, Martins RN (2005) Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoforms specific receptor binding. J Alzheimers Dis 7, 303-314.
• Youn H, Ji I, Ji HP, Markesbery WR, Ji TH (2007) Under-expression of Kalirin-7 increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. J Alzheimers Dis 12, 271-281.

Gail V. W. Johnson Voll, Ph.D.

• Ding H, Matthews TA, Johnson GV (2006) Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. J Biol Chem 281, 19107-19114.
• Chun W, Waldo GS, Johnson GV (2007) Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage. J Neurochem 103, 2529-2539.
• Chun W, Johnson GV (2007) Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy. J Biol Chem 282, 23410-23417.
• Chun W, Johnson GV (2007) The role of tau phosphorylation and cleavage in neuronal cell death. Front Biosci 12, 733-756.

Angela R. Kamer, DDS, MS, PhD

• Kamer AR, Sacks PG, Vladutiu A, Liebow C (2004) EGF mediates multiple signals: dependence on conditions. Int J Mol Med 13, 143-147.
• Kamer AR, Sirois D, Huhmaan M (2005). Bidirectional Impact of oral health and general health. In: Nutrition and Oral Medicine, Touger-Decker R, Sirois D, Mobley C (Eds). Humana Press, Inc. Totowa, New Jersey.
• Kamer AR, El-Ghorab N, Marzek N, Margarone JE III, Dziak R (2006) Nicotine induced proliferation and cytokine release in osteoblastic cells. Int J Mol Med 17, 121-127.
• Craig RG, Kotanko P, Kamer AR, Levin NW (2007) Periodontal diseases: A modifiable source of systemic inflammation for the end stage renal disease patient on hemodialysis therapy? Nephrology, Dialysis and Transplantation 22, 312-315.

Marian L. Kruzel, Ph.D.

• Schuster D, Rajendran A, Hui SW, Nicotera T, Srikrishnan T, Kruzel ML (2005) Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of beta-amyloid. Neuropeptides 39, 419-426.
• Bacsi A, Stanton J, Hughes T, Kruzel M, Boldogh I (2005) Colostrinin-driven neurite outgrowth requires p53 activation in PC12 cells. Cell Mol Neurobiol 25, 1123-1139.
• Bourhim M, Kruzel M, Srikrishnan T, Nicotera T (2007) Linear quantitation of Aβ aggregation using Thioflavin T: Reduction in fibril formation by colostrinin. J Neurosci Methods 160, 264-268.
• Bacsi A, Woodberry M, Kruzel ML, Boldogh I (2007) Colostrinin delays the onset of proliferative senescence of diploid murine fibroblast cells. Neuropeptides 41, 93-101.

Dr. Jeff Kuret

• Kannanayakal TJ, Tao H, Vandre DD, Kuret J (2006) Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions. Acta Neuropathol 111, 413-421.
• Honson NS, Johnson RL, Huang W, Inglese J, Austin CP, Kuret J (2007) Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiol Dis 28, 251-260.
• Bandyopadhyay B, Li G Yin H, Kuret J (2007) Tau aggregation and toxicity in a cell culture model of tauopathy.  J Biol Chem 282, 16454-16464.
• Congdon EE, Kim S, Bonchak J, Songrug T, Matzavinos A, Kuret J (2008) Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants. J Biol Chem 283, 13806-13816.

Christoph Laske, M.D.

• Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, Soekadar S, Richartz E, Koehler N, Bartels M, Buchkremer G, Schott K (2007) BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 41, 387-394.
• Laske C, Leyhe T, Stransky E, Eschweiler GW, Bueltmann A, Langer H, Stellos K, Gawaz M (2007) Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer’s disease. J Psychiatr Res, in press
• Leyhe T, Stransky E, Eschweiler GW, Buchkremer G, Laske C (2008) Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer’s disease. Eur Arch Psychiatry Clin Neurosci 258, 124-128.
• Laske C, Stellos K, Eschweiler GW, Leyhe T, Gawaz M (2008) Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer’s disease: a contribution to a deficient hematopoietic brain support? J Alzheimers Dis, in press.

Virginia M.-Y. Lee, Ph.D.

• Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM (2005) Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 45, 847-859.
• Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM (2005) BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J Cell Biol 168, 291-302.
• Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 42-43.
• Yoshiyama Y, Higuchi M, Zhang B, Huang S-M, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VMY (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351.

Geneviève Leuba, Ph.D.

• Savioz A, Riederer BM, Heutink P, Rizzu P, Tolnay M, Kovari E, Probst A, Riederer IM, Bouras C, Leuba G (2003) Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22. Neurobiol Dis 12, 46-55.
• Leuba G, Vernay A, Vu D, Walzer C, Belloir B, Kraftsik R, Bouras C, Savioz A (2004) Differential expression of LMO4 protein in Alzheimer's disease. Neuropathol Appl Neurobiol 30, 57-69.
• Leuba G, Wernli G, Vernay A, Kraftsik R, Mohajeri MH, Saini KD (2005) Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease. Dement Geriatr Cogn Disord 19, 171-183.
• Leuba G, Walzer C, Vernay A, Carnal B, Kraftsik R, Piotton F, Marin P, Bouras C, Savioz A. (2008) Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction. Neurobiol Dis, in press.

Dr. Min Li

• Liu CL, Xie LX, Li M*, Kumar DSS, Goto S, Huang JD* (2007) Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt and Bcl-2 pathways. PlotS. ONE 2, e1321.doi:10.1371/ journal.pone.0001321. 2007.12.19 (*co-corresponding author).
• Li M, Zhao MQ, Kumar DSS, Xie LX, Zhang HX, Kum WF, Goto S, Liao FL (2008) Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress. Clin Hemorhe Mecro 38, 177-187.
• Kumar DSS, Yuan QJ, Xie LX, Chan WS, Kum WF, Koo I, Liu CL, Song YQ, Huang JD*, Klein WL, Li M* (2008) Salvianolic acid B inhibits Aβ fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity. Neurochem Int 52, 741-750 (*co-corresponding author).
• Man SC, Kumar DSS, Kum WF, Lu JH, Huang JD, Cheng CF, Chung V, Xu M, Li M (2008) Systematic review of the efficacy and safety of herbal medicines for Alzheimer’s disease. J Alzheimers Dis, in press.

Miguel A. Lopez-Toledano, Ph.D.

• López-Toledano MA, Shelanski M (2004) Neurogenic effect of beta-amyloid peptide in the development of Neural Stem Cells. J Neurosci 24, 5439-5444
• López-Toledano MA, Redondo C, Lobo MVT, Reimers D, Herranz AS, Paino CL, Bazán E (2004) Tyrosine hydroxylase induction by basic fibroblast growth factor and cyclic AMP analogs in striatal neural stem cells: Role of ERK1/ERK2 mitogen-activated protein kinase and protein kinase C. J Histochem Cytochem 52, 1177-1191.
• Perez-Olle R, Lopez-Toledano MA, Cabrera-Poch N, Stefanis L, Brown K, Liem RKH (2005) Generalized transport defects caused by neurofilament light gene mutations linked to Charcot-Marie-Tooth. J Neurochem 93, 861-874.
• Redondo C, López-Toledano MA, Lobo MV, Gonzalo-Gobernado R, Reimers D, Herranz AS, Paino CL, Bazán E (2007) Kainic acid triggers oligodendrocyte precursor cell proliferation and neuronal differenation from striatal neural stem cells. J Neurosci Res 85, 1170-1182.

Dr. Yuan Luo

• Wu YJ, Luo Y (2005) Transgenic C. elegans as a model in Alzheimer’s research. Curr Alzheimer Res 2, 37-45.
• Wu Y, Wu ZX, Christen Y, Lambert MP, Klein ML, Link CD, Luo Y (2006) Amyloid beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26, 13102-13113.
• Xu Y, Cui C, Christen Y, Luo Y (2007) Restoration of impaired phosphorylation of cyclic AMP response element binding protein (CREB) by EGb 761 and its constituents in Aβ-expressing neuroblastoma cells. Eur J Neurosci 26, 2931-2939.
• Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y (2007) EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 21, 2400-2408.

Prof. Ian G. Macreadie

• Westermeyer C, Macreadie IG (2007) Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mitochondrial DNA in Candida glabrata. FEMS Yeast Res 7, 436-441.
• Caine J, Sankovich S, Antony H, Waddington L, Macreadie P, Varghese J, Macreadie I (2007) Alzheimer's Aβ fused to green fluorescent protein induces growth stress and a heat shock response. FEMS Yeast Res 7, 1230-1236.
• Wikhe K, Westermeyer C, Macreadie IG (2007) Biological consequences of statins in Candida species and possible implications for human health. Biochem Soc Trans 35 (Pt 6), 1529-1532.
• Macreadie IG (2007) Copper transport and Alzheimer’s disease. Eur J Biophys, in press.

Michelangelo Mancuso, M.D., Ph.D.

• Micheli D, Bonvicini C, Rocchi A, Ceravolo R, Mancuso M, Tognoni G, Gennarelli M, Siciliano G, Murri L (2006) No evidence for allelic association of serotonin 2a receptor and transporter gene polymorphisms with depression in Alzheimer disease. J Alzheimers Dis 10, 371-378.
• Mancuso M, Nardini M, Micheli D, Rocchi A, Nesti C, Giglioli NJ, Petrozzi L, Rossi C, Ceravolo R, Bacci A, Choub A, Ricci G, Tognoni G, Manca ML, Siciliano G, Murri L (2007) Lack of association between mtDNA haplogroups and Alzheimer's disease in Tuscany. Neurol Sci 28, 142-147.
• Coppede F, Mancuso M, Gerfo AL, Manca ML, Petrozzi L, Migliore L, Siciliano G, Murri L (2007) A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. Neurosci Lett 414, 282-285.
• Mancuso M, Coppedè F, Siciliano G, Murri L (2007) Mitochondrial cascade hypothesis of Alzheimer’s disease: myth or reality? Antiox Redox Signal 9, 1631-1646.

Dr. Ralph Martins

• Laws SM, Hone E, Gandy S, Martins RN (2003) Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. J Neurochem 84, 1215-1236.
• Bowen RL*, Verdile G*, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS (2004) Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-ß precursor protein and amyloid-ß deposition. J Biol Chem 279, 20539-20545. * shared first author
• Verdile G, Groth D, Mathews P, St-George Hyslop PH, Fraser P, Ramabhadran TV, Kwok JBJ, Schofield PR, Carter T, Gandy S, Martins RN (2004) Baculoviruses expressing the human familial Alzheimer’s disease presenilin 1 mutation lacking exon9 increase levels of an amyloid beta-like protein in Sf9 cells. Mol Psychiatry 9, 594-602.
• Burkhardt MS, Foster JK, Laws SM, Baker LD, Craft S, Gandy SE, Stuckey BGA, Clarnette R, Nolan D, Hewson-Bower B, Martins RN (2004) Oestrogen replacement therapy may improve memory functioning in the absence of APOE 4. J Alzheimers Dis 6, 221-228.

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Patrizia Mecocci, M.D., Ph.D.

• Polidori MC, Mariani E, Baggio G, Deiana L, Carru C, Pes GM, Cecchetti R, Franceschi C, Senin U, Mecocci P (2007) Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity. Eur J Clin Nutr 61, 922-924.
• Mariani E, Monastero R, Ercolani S, Mangialasche F, Caputo M, Feliziani FT, Vitale DF, Senin U, Mecocci P (2007) Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl Project. Dement Geriatr Cogn Disord 24, 448-456.
• Polidori MC, Griffiths HR, Mariani E, Mecocci P (2007) Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids 32, 553-559.
• Ravaglia G, Forti P, Montesi F, Lucicesare A, Pisacane N, Rietti E, Dalmonte E, Bianchin M, Mecocci P (2007) Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population. J Am Geriatr Soc, in press.

Manuel Menendez-Gonzalez

• Menéndez González M, García Fernández C, Antón González C, González González S, Blázquez Menes B (2005) Pérdida de memoria como motivo de consulta. Neurología 20, 390-394.
• Menéndez-González M, Pérez-Pinera P, Martínez-Rivera M, Calatayud MT, Blázquez Menes B (2005) APP processing and the APP-KPI domain involvement in the amyloid cascade. Neurodegener Dis 2, 277-283.
• González P, Alvarez V, Menéndez M, Lahoz CH, Martínez C, Corao AI, Calatayud MT, Peña J, García-Castro M, Coto E (2007) Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms. Neurosci Lett 411, 47-51.
• Cuetos-Vega F, Menendez-González M, Calatayud-Noguera T (2007) Description of a novel test for the early detection of Alzheimer's disease. Rev Neurol 44, 469-474.

Judith Miklossy, M.D., Ph.D.

• Miklossy J (2008) Chronic inflammation and amyloidogenesis in Alzheimer’s disease – role of spirochetes. J Alzheimers Dis 13, 381-391.
• Miklossy J (2008) Biology and neuropathology of dementia in syphilis and Lyme disease. Handb Clin Neurol 89, 825-844.
• Miklossy J, Kasas S, Zurn A, McCall S, Yu S, McGeer PL (2008) Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. J Neuroinflammation 5, 40.
• Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F,  Khalili K, Darbinian-Sarlissian N, McGeer PL (2008) Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging, in press.

Dr. Andrei C. Miu

• Miu AC, Andreescu CE, Vasiu R, Olteanu AI (2003) A behavioral and histological study of the effects of long-term exposure of adult rats to aluminum. Int J Neurosci 113, 1197-1211.
• Miu AC, Olteanu AI, Miclea M (2004) A behavioral and ultrastructural dissection of the interference of aluminum with aging. J Alzheimers Dis 6, 315-328.
• Miu AC (2006) The silicon link between aluminium and Alzheimer's disease. J Alzheimers Dis 10, 39-42.
• Miu AC, Benga O (2006) Aluminum and Alzheimer's disease: A new look. J Alzheimers Dis 10, 179-201.

Dr. Thomas Montine

• Montine TJ, Quinn J, Kaye J, Morrow JD (2007) F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease. J Mol Neurosci 33, 114-119.
• Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ (2007) Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 62, 406-413.
• Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JC, Montine TJ (2007) Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 69, 878-885.
• Li G, Sokal I, Quinn JF, Leverenz JB, Brodey M, Schellenberg GD, Kaye JA, Raskind MA, Zhang J, Peskind ER, Montine TJ (2007) CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment: a follow-up study. Neurology 69, 631-639.

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Paula I. Moreira, Ph.D.

• Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis 12, 195-206.
• Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G (2007) Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 3, 614-615.
• Moreira PI, Santos MS, Oliveira CR (2007) Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal 9, 1621-1630.
• Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 66, 525-532.

Vito Davide Moretti, M.D., Ph.D.

• Moretti, DV, Babiloni C, Binetti G, Cassetta E, Dal Forno G, Ferreri F, Ferri R, Lanuzza B, Miniussi C, Nobili F,  Rodriguez G, Salinari S, Rossini PM (2004) Individual analysis of EEG frequency and band power in mild Alzheimer’s Disease. Clin Neurophysiol 115, 299-308.
• Babiloni C, Cassetta E, Dal Forno G, Del Percio C, Ferreri F, Ferri R, Lanuzza B, Miniussi C, Moretti DV, Nobili F, Pascual-Marqui RD, Rodriguez G, Romani GL, Salinari S, Zanetti O,  Rossini PM (2006) Donepezil effects on sources of cortical rhythms in mild Alzheimers disease: responders vs. non responders. Neuroimage 31, 1650-1665.
• Moretti DV, Miniussi C, Frisoni G, Zanetti O, Binetti G, Geroldi C, Galluzzi S, Rossini PM (2007) Vascular damage and EEG markers in subjects with mild cognitive impairment. Clin Neurophysiol 118, 1866-1876.
• Moretti DV, Miniussi C, Frisoni GB, Geroldi C, Zanetti O, Binetti G, Rossini PM (2007) Hippocampal atrophy and EEG markers in subjects with mild cognitive impairment. Clin Neurophysiol 118, 2716-2729.

Martha Clare Morris, Sc.D.

• Morris MC, Scherr PA, Hebert LE, Tangney CC, Evans DA, Bienias JL (2004) Dietary niacin and reduced risk of incident Alzheimer’s disease and of cognitive decline. J Neurol Neurosurg Psych 75, 1093-1099.
• Morris MC, Tangney CC, Evans DA, Bienias JL, Wilson RS (2005) Fish consumption and cognitive decline with age in a large community study. Arch Neurol 62, 1849-1853.
• Morris MC, Evans DA, Bienias JL, Tangney CC, Hebert LE, Scherr PA, Schneider JA (2005) Dietary folate and vitamin B-12 and cognitive decline among community dwelling older persons. Arch Neurol 62, 641-645.
• Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS, Aggarwal NT, Scherr PA (2005) Relation of tocopherol forms to incident Alzheimer’s disease and to cognitive change. Am J Clin Nutr 81, 508-514.

Gerd Multhaup, Ph.D.

• Schmechel A, Zentgraf H, Scheuermann S, Fritz G, Pipkorn R, Reed J, Beyreuther K, Bayer TA, Multhaup G (2003) Alzheimer's beta-amyloid homodimers facilitate Aß fibrillization and the generation of conformational antibodies. J Biol Chem 278, 35317-35324.
• Bayer TA, Schäfer S, Simons A, Kemmling A, Kamer T, Tepest R, Eckert A, Schüssel K, Eikenberg O, Sturchler-Pierrat Ch, Abramowski D, Staufenbiel M, Multhaup G (2003) Dietary Cu stabilizes brain SOD-1 activity and reduces amyloid Aß production in APP23 transgenic mice. Proc Natl Acad Sci 100, 14187-14192.
• Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G (2004) Human BACE forms dimers and colocalizes with APP. J Biol Chem 279, 39710-39717.
• Treiber C, Simons A, Strauss M, Hafner M, Cappai R, Bayer TA, Multhaup G (2004) Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease. J Biol Chem 279, 51958-51964.

Dr. Alexander Navarrete Santos

• Trieschmann L, Navarrete Santos A, Kaschig K, Torkler S, Maas E, Schatzl H, Bohm G (2005) Ultra-sensitive detection of prion protein fibrils by flow cytometry in blood from cattle affected with bovine spongiform encephalopathy. BMC Biotechnol 5, 26.
• Nass N, Bartling B, Navarrete Santos A, Scheubel RJ, Börgermann J, Silber RE, Simm A (2007) Advanced glycation end products, diabetes and ageing. Z Gerontol Geriatr 40, 349-356.
• Navarrete Santos A, Torkler S, Nowak D, Schlittig C, Goerdes M, Lauber T, Trischmann L, Schaupp M, Penz M, Tiller FW, Böhm G (2007) Detection of amyloid-ß oligomers in human cerebrospinal fluid by flow cytometry and
  fluorescence resonance energy transfer. J Alzheimers Dis 11, 117-125.
• Simm A, Nass N, Bartling B, Hoffmann B, Silber RE, Santos AN (2008) Potential biomarkers of ageing. Biol Chem, in press.

Michal Novak, MVD, PhD

• Zilka N, Filipcik P, Koson P, Fialova L, Skrabana R, Zilkova M, Rolkova G, Kontsekova E, Novak M (2006) Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett 580, 3582-3588.
• Hrnkova M, Zilka N, Minichova Z, Koson P, Novak M. Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats. Brain Res 1130, 206-213.
• Sevcik J, Skrabana R, Dvorsky R, Csokova N, Iqbal K, Novak M. X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease. FEBS Lett 581, 5872-5878.
• Stozická Z, Zilka N, Novák M. Risk and protective factors for sporadic Alzheimer's disease. Acta Virol 51, 205-222.

Catarina Oliveira, M.D., Ph.D.

• Resende R, Pereira C, Agostinho P, Vieira AP, Malva JO, Oliveira CR (2007) Susceptibility of hippocampal neurons to Aβ peptides toxicity is associated with perturbation of Ca2+ homeostasis. Brain Res 1143, 11-21.
• Moreira PI, Santos MS, Seiça R, Oliveira CR (2007) Brain mitochondria dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci 257, 206-214.
• Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR (2007) Street  heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J Neurochem101, 543-554.
• Ferreiro E, Oliveira CR, Pereira C (2007) The release of endoplasmic reticulum calcium induced by amyloid-beta and prion peptides activates the mitochondrial pathway. Neurobiol Dis, in press.

Carola Otth, Ph.D.

• Otth C, Mendoza-Naranjo A, Mujica L, Zambrano A, Concha II, Maccioni RB (2003) Modulation of the JNK and p38 pathways by cdk5 kinase in a transgenic mouse model of Alzheimer’s disease. Neuroreport 14, 2403-2409.
• Otth C, Torres M, Ramirez A, Fernandez JC, Castro M, Rauch C, Brito M, Yañez AJ, Rodríguez-Gil JE, Slebe JC, Concha II (2007) Novel identification of peripheral dopaminergic D2 receptor in rat male germ cells. J Cell Biochem 100, 141-150.
• Zambrano A, Otth C, Mujica L, Concha II, Maccioni RB (2007) Interleukin-3 prevents neuronal death induced by amyloid peptide. BMC Neurosci 8, 82.
• Zambrano A, Solis L, Salvadores N, Cortés M, Lerchundi R, Otth C (2008) Neuronal cytoskeletaldynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1. J Alzheimers Dis, in press.

Francesco Panza, M.D., Ph.D.

• Panza F, D'Introno A, Colacicco AM, Capurso C, Del Parigi A, Caselli RJ, Pilotto A, Argentieri G, Scapicchio PL, Scafato E, Capurso A, Solfrizzi V (2005) Current epidemiology of mild cognitive impairment and other predementia syndromes. Am J Geriatr Psychiatry 13, 633-644.
• Panza F, D'Introno A, Colacicco AM, Capurso C, Parigi AD, Capurso SA, Caselli RJ, Pilotto A, Scafato E, Capurso A, Solfrizzi V (2006) Cognitive frailty: Predementia syndrome and vascular risk factors. Neurobiol Aging 27, 933-940.
• Panza F, D'Introno A, Colacicco AM, Capurso C, Pichichero G, Capurso SA, Capurso A, Solfrizzi V (2006) Lipid metabolism in cognitive decline and dementia. Brain Res Rev 51, 275-292.
• Solfrizzi V, D'Introno A, Colacicco AM, Capurso C, Del Parigi A, Baldassarre G, Scapicchio P, Scafato E, Amodio M, Capurso A, Panza; Italian Longitudinal Study on Aging (2007) Alcohol consumption, mild cognitive impairment, and progression to dementia. Neurology 68, 1790-1799.

Sozos Ch. Papasozomenos, M.D.

• Papasozomenos SC (1996) Heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats: implications for Alzheimer’s disease. J Neurochem 66, 1140-1149.
• Papasozomenos SC (1997) The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease. Proc Natl Acad Sci U S A 94, 6612-6617.
• Papasozomenos SC, Papasozomenos T (1999) Androgens prevent the heat shock-induced hyperphosphorylation but not dephosphorylation of tau in female rats. Implications for Alzheimer’s disease. J Alzheimers Dis 1, 147-153.
• Papasozomenos SC, Shanavas A (2002) Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau: implications for Alzheimer’s disease. Proc Natl Acad Sci U S A 99, 1140-1145.

Giulio Maria Pasinetti, M.D.

• Pasinetti GM, Ungar LH, Lange DJ, Yemul S, Brown RH, Cudkowicz ME, Newhall K, Peskind E, Marcus S, Ho L (2006) Identification of potential cerebrospinal fluid biomarkers in amyotrophic lateral sclerosis. Neurology 66, 1218-1222.
• Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng HH, Pedrini S, Gandy S, Sauve A, Pasinetti GM (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer's disease amyloid neuropathology by calorie restriction. J Biol Chem 281, 21745-21754.
• Zhao Z, Xiang Z, Haroutunian V, Buxbaum J, Stetka B, Pasinetti GM (2006) Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol Aging 28, 824-830.
• Wang J, Zhao Z, Ho L, Seror I, Humala N, Percival S, Pasinetti GM (2006) Moderate consumption of Cabernet Sauvignon attenuates β-amyloid neuropathology in a mouse model of Alzheimer’s disease. FASEB J 20, 2313-2320.

Jin-Jing Pei, M.D., Ph.D.

• Pei J-J, Gong C-X, An W-L, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K (2003) Okadaic acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2 and p70 S6 similar to that in Alzheimer’s disease. Am J Pathol 163, 845-858.
• An W-L, Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Grundke-Iqbal I, Winblad B, Pei J-J (2003) Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer’s disease. Am J Pathol 163, 591-607.
• Pei J-J, Khatoon S, An W-L, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K (2003) Role of protein kinase B in Alzheimer's neurofibrillary degeneration. Acta Neuropathol 105, 381-392.
• Liu R, Zhou X-W, Tanila H, Bjorkdahl C, Wang J-Z, Guan Z-Z, Gustafsson J-Å, Winblad B, Pei J-J (2008) Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med 12, 241-257.

Silvia Pellegrini, Ph.D.

• Rocchi A, Pellegrini S, Siciliano G, Murri L (2003) Causative and susceptibility genes for Alzheimer’s disease: a review. Brain Res Bull 61, 1-24.
• Conte A, Pellegrini S, Tagliazucchi D (2003) Synergistic protection of PC12 cells from beta-amyloid toxicity by resveratrol and catechin. Brain Res Bull 62, 29-38.
• Cozza A, Morandin F, Galfre SG, Mariotti V, Marangoni R, Pellegrini S (2007) TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach. BMC Genomics 8, 10.
• Cozza A, Melissari E, Iacopetti P, Mariotti V, Tedde A, Nacmias B, Conte A, Sorbi S, Pellegrini S (2008) SNPs in neurotrophin system genes and Alzheimer’s disease in an Italian population. J Alzheimers Dis 15, 61-70.

Maire E. Percy, Ph.D.

• Kruck TP, Cui JG, Percy ME, Lukiw WJ (2004) Molecular shuttle chelation: The use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum. Cell Mol Neurobiol 24, 443-459.
• Alexandrov PN, Zhao Y, Pogue AI, Tarr MA, Kruck TP, Percy ME, Cui JG, Lukiw WJ (2005) Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis 8, 117-127.
• Kruck TP, Percy ME, Lukiw WJ (2008) Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-G. Neuroreport 19, 245-249.
• Percy M, Moalem S, Garcia A, Somerville MJ, Hicks M, Andrews D, Azad A, Schwarz P, Beheshti Zavareh R, Birkan R, Choo C , Chow V, Dhaliwal S, Kupferschmidt AL, Lam K, Lightman D, Machalek K, Mar W, Nguyen F, Rytwinski PJ, Svara E, Tran M, Yeung L, Zanibbi K, Zener R, Ziraldo M, Freedman M (2008) Involvement of ApoE E4 and H63D in sporadic Alzheimer disease in a folate-supplemented Ontario population. J Alzheimers Dis, in press.

George Perry, Ph.D.

• Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira P, Miller F, Nunomura A, Shimohama S, Perry G (2005) Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem 280, 20978-20986.
• Perry G, Avila J, Kinoshita J, Smith MA (Eds.) (2006) Alzheimer’s Disease: A Century of Scientific and Clinical Research, IOS Press, Amsterdam, pp. 450.
• Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 66, 525-532.
• Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Hayashi Y, Nakayama K, Hayashi T (2007) Three histidine residues of amyloid-β peptide control the redox activity of copper and iron. Biochemistry 46, 12737-12743.

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Prof. Laura Petrosini

• Torriero S, Oliveri M, Koch G, Caltagirone C, Petrosini L (2007) The what and how of observational learning. J Cogn Neurosci 19, 1656-1663.
• Petrosini L (2007) "Do what I do" and "do how I do": different components of imitative learning are mediated by different neural structures. Neuroscientist 13, 335-348.
• Cutuli D, Foti F, Mandolesi L, Bartolo PD, Gelfo F, Federico F, Petrosini L (2008) Cognitive performance of healthy young rats following chronic donepezil administration. Psychopharmacology (Berl), in press.
• De Bartolo P, Leggio MG, Mandolesi L, Foti F, Gelfo F, Ferlazzo F, Petrosini L (2008) Environmental enrichment mitigates the effects of basal forebrain lesions on cognitive flexibility. Neuroscience, in press.

Dr. María J. Ramírez

• Garcia-Alloza M, Gil-Bea FJ, Diez-Ariza M, Chen CP, Francis PT, Lasheras B, Ramirez MJ (2005) Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease. Neuropsychologia 43, 442-449.
• Garcia-Alloza M, Zaldua N, Diez-Ariza M, Marcos B, Lasheras B, Javier Gil-Bea F, Ramirez MJ (2006) Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J Neuropathol Exp Neurol 65, 1074-1081.
• Garcia-Alloza M, Tsang SW, Gil-Bea FJ, Francis PT, Lai MK, Marcos B, Chen CP, Ramirez MJ (2006) Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. Neurobiol Aging 27, 1110-1117.
• Gil-Bea FJ, Aisa B, Schliebs R, Ramírez MJ (2007) Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice. Behav Neurosci 121, 340-344.

Marcella Reale, Ph.D.

• Gambi F, Reale M, Iarlori C, Salone A, Toma L, Paladini C, De Luca G, Feliciani C, Salvatore M, Salerno RM, Theoharides TC, Conti P, Exton M, Gambi D (2004) Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells. J Clin Psychopharmacol 24, 314-321.
• Reale M, Iarlori C, Gambi F, Lucci I, Salvatore M, Gambi D (2005) Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Exp Gerontol 40, 165-171.
• Iarlori C, Gambi D, Gambi F, Lucci I, Feliciani C, Salvatore M, Reale M (2005) Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease. Exp Gerontol 40, 605-611.
• Reale M, Iarlori C, Gambi F, Feliciani C, Isabella L, Gambi D (2006) The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients. Neuropharmacology 50, 606-613.

A. Cristina Rego, Ph.D.

• Moreira PI, Santos MS, Moreno A, Rego AC, Oliveira C (2002) Effect of amyloid β–peptide on permeability transition pore: a comparative study. J Neurosci Res 69, 257-267.
• Rego AC, Oliveira CR (2003) Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis – implications for the pathogenesis of neurodegenerative diseases. Neurochem Res 28, 1563-1574.
• Cardoso SM, Rego AC, Pereira C, Oliveira CR (2005) Protective effect of zinc on amyloid b 25-35 and 1-40 mediated toxicity. Neurotox Res 7, 273-282.
• Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC (2007) Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem Int 50, 872-880.

Dr. Jill Richardson

• Culbert A, Skaper S, Howlett D, Evans N, Facci L, Soden PE, Seymour Z, Guillot F, Gaestel M, Richardson JC (2006) MAPKAPK2 kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. J Biol Chem 281, 23658-23667.
• Cole AR, Noble W, Aalten LV, Plattner F, Meimaridou R, Hogan D, Taylor M, Lafrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, Laferla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C (2007) Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer’s disease progression. J Neurochem 103, 1132-1144.
• Pugh PL, Vidgeon-Hart MP, Ashmeade T, Culbert AA, Seymour Z, Perren MJ, Joyce F, Bate ST, Babin A, Virley DJ, Richardson JC, Upton N, Sunter D (2007) Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes. J Neuroinflammation 4, 8.
• Pugh P, Richardson JC, Bate ST, Upton N, Sunter D (2007) Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer’s disease. Behav Brain Res 178, 18-28.

Juha O. Rinne, MD, PhD

• Remes AM, Laru L, Tuominen H, Aalto S, Kemppainen N, Mononen H, Någren K, Parkkola R, Rinne JO (2008) Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication. Arch Neurol 65, 540-544.
• Virta JJ, Karrasch M, Kaprio J, Koskenvuo M, Räihä I, Viljanen T, Rinne JO (2008) Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer’s disease. Dement Geriatr Cogn Disord 25, 9-16.
• Kemppainen NM, Aalto S, Karrasch M, Någren K, Savisto N, Oikonen V, Viitanen M, Parkkola R, Rinne JO (2008) Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. Ann Neurol 63, 112-118.
• Koivunen J, Verkkoniemi A, Aalto S, Paetau A, Ahonen JP, Viitanen M, Någren K, Rokka J, Haaparanta M, Kalimo H, Rinne JO (2008) PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease. Brain, in press.

Hanno M. Roder, Ph.D.

• Le Corre S,  Klafki H, Plesnila N, Hübinger G, Sahagun-Krause G, Thal S, Lewis J, Dickson DW, Monse B, Hutton M, Roder HM (2006) Inhibition of pathological tau hyperphosphorylation in vivo and delay of progressive motor disturbance in a transgenic mouse model of tauopathy. Proc Natl Acad Sci USA 103, 9673-9678.
• Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, Yue M, Wszolek Z, Ashe K, Knight J, Dickson D, Andorfer C, Rosenberry TL, Lewis J, Hutton M, Janus C. (2007) Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. J Neurosci 27, 3650-3662.
• Roder HM, Hutton ML (2007) Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease. Expert Opin Ther Targets 11, 435-442.
• Hübinger G, Geis S, Mühlbacher S, Gordon S, Fracasso RP, Ferrand S, Klafki HW, Roder HM (2008) Inhibition of PHF-like tau hyperphosphorylation by the ERK/cdk inhibitor K252a in SH-SY5Y cells. J Alzheimers Dis, in press.

Dr. Carmen Quintana Rodríguez

• Quintana C, Cowley JM, Marhic C (2004) Electron nanodiffraction and high resolution electron microscopy studies of the structure and composition of physiological and pathological ferritin. J Struct Biol 147, 166-178.
• Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, Ferrer I, Patiño C, Arranz R (2006). Study of the localization of iron, ferritin and hemosiderin in Alzheimer?s disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol 153, 42-54.
• Quintana C, Wu T, Delatour B, Dhenain M, Guerquin-Kern JL, Croisy A (2007) Morphological and chemical studies of pathological human and mice at the subcellular level: correlation between light, electron and nanoSIMS microscopies. Microsc Res Techn 70, 281-295.
• Quintana C (2007) Contribution of analytical microscopies to human neurodegenerative diseases research (PSP and AD). Mini-Rev Med Chem 7, 961-975.

Marwan N. Sabbagh, M.D., F.A.A.N.

• Lyketsos CG, Breitner JCS, Green RC, Martin BK, Meinert C, Piantadosi S, Sabbagh M for the ADAPT Research Group (2007) No immediate reduction in AD incidence with naproxen and celecoxib: results from a randomized prevention trial. Neurology 68, 1800-1809.
• Beach TG, Sue LI, Walker DG, Lue LF, Caviness J, Sabbagh MN, Adler CH (2007) Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits. Acta Neuropathol 114, :419-424.
• Sabbagh MN, Lahti T, Connor DJ, Caviness JN, Shill H, Vedders L, Mahant P, Samanta J, Burns RS, Evidente VG, Driver-Dunckley E, Reisberg B, Bircea S, Adler CH (2007) Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease. Dement Geriatr Cogn Disord 24, 327-334.
• Thind K, Sabbagh MN (2007) Pathological correlates of cognitive decline in Alzheimer’s disease. PanMinerva Medica49, 191-195.

Dr. John Savory

• Savory J, Ghribi O, Herman MM (2002)  Is amyloid ß-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?  Neurobiol Aging 23, 1089-1092.
• Grant WB, Campbell A, Itzhaki RF, Savory J (2002) The significance of environmental factors in the etiology of Alzheimer's disease.  J Alzheimers Dis 4, 179-189.
• Ghribi O, Pramoonjago P, Herman MM, Savory J (2003) Aß(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau. Mol Brain Res 119, 201-206.
• Ghribi O, Herman MM, Pramoonjago P, Spaulding NK, Savory J (2004) GDNF regulates the Aß-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases. Neurobiol Dis 16, 417-427.

Sigfrido Scarpa, Ph.D.

• Scarpa S, Cavallaro RA, D’Anselmi F, Fuso A (2006) Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J Alzheimers Dis 9, 407-414.
• Cavallaro RA, Fuso A, D’Anselmi F, Seminara L, Scarpa S (2006) The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarrays analysis. J Alzheimers Dis 9, 415-419.
• Riccioli A, Starace D, Galli R, Fuso A, Scarpa S, Palombi F, De Cesaris P, Ziparo E, Filippini A (2006) Sertoli cells initiate testicular innate immune responses through TLR activation. J Immunol 177, 7122-7130.
• Fuso A, Nicolia V, Cavallaro RA, Ricceri L, D'Anselmi F, Coluccia P, Calamandrei G, Scarpa S (2008) B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocsyteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice. Mol Cell Neurosci 37, 731-746.

Dr. Davide Seripa

• Poleggi A, Bizzarro A, Acciarri A, Antuono P, Bagnoli S, Cellini E, Forno GD, Giannattasio C, Lauria A, Matera MG, Nacmias B, Puopolo M, Seripa D, Sorbi S, Wekstein DR, Pocchiari M, Masullo C (2008) Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease. Eur J Neurol 15, 173-178.
• Capurso C, Solfrizzi V, D'Introno A, Colacicco AM, Capurso SA, Bifaro L, Menga R, Santamato A, Seripa D, Pilotto A, Capurso A, Panza F (2008) Short arm of chromosome 11 and sporadic Alzheimer's disease: Catalase and cathepsin D gene polymorphisms. Neurosci Lett 432, 237-242.
• Seripa D, Matera MG, Franceschi M, Bizzarro A, Paris F, Cascavilla L, Rinaldi M, Panza F, Solfrizzi V, Daniele A, Masullo C, Dallapiccola B, Pilotto A (2008) Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease. Dement Geriatr Cogn Disord 25, 287-292.
• Giannattasio C, Poleggi A, Puopolo M, Pocchiari M, Antuono P, Dal Forno G, Wekstein DR, Matera MG, Seripa D, Acciarri A, Bizzarro A, Lauria A, Masullo C (2008) Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon4 allele. Dement Geriatr Cogn Disord 25, 354-358.

Alessandro Serretti, M.D.

• De Ronchi D, Bellini F, Berardi D, Serretti A, Ferrari B, Dalmonte E (2005) Cognitive status, depressive symptoms, and health status as predictors of functional disability among elderly persons with low-to-moderate education: The Faenza Community Aging Study. Am J Geriatr Psychiatry 13, 672-685.
• De Ronchi D, Berardi D, Menchetti M, Ferrari G, Serretti A, Dalmonte E, Fratiglioni L (2005) Occurrence of cognitive impairment and dementia after the age of 60: a population-based study from Northern Italy. Dement Geriatr Cogn Disord 19, 97-105.
• Serretti A, Artioli P, Quartesan R, De Ronchi D (2005) Genes involved in Alzheimer's disease, a survey of possible candidates. J Alzheimers Dis 7, 331-353.
• Serretti A, Olgiati P, De Ronchi D (2007) Genetics of Alzheimer's disease. A rapidly evolving field. J Alzheimers Dis 12, 73-92.

Sudha Seshadri, M.D.

• Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346, 476-483.
• Zaldy ST, Seshadri S, Beiser A, Zhang Y, Felson D, Hannan MT, Au R, Wolf PA, Kiel DP (2005) Bone mineral disease and the risk of Alzheimer’s disease. Arch Neurol 62, 107-111.
• Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA (2006) Lifetime risk of stroke and dementia. Stroke 2, 345-350.
• Akomolafe A, Beiser AS, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S (2006) Diabetes mellitus and risk of developing Alzheimer’s dementia: results from the Framingham Study. Arch Neurol 63, 1551-1555.

Thomas B. Shea, Ph.D.

• Tchantchou F, Graves M, Rogers E, Ortiz D, Shea TB (2005) Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: Relevance to age-related neurodegeneration. Neuromol Med 6, 93-104.
• Tchantchou F, Chan A, Kifle L, Ortiz D, Shea TB (2005) Apple juice concentrate prevents oxidative damage and cognitive decline in aged mice. J Alzheimers Dis 8, 283-287.,
• Tchantchou F, Graves M, Rogers E, Ortiz D, Shea TB (2005) N-acetyl cysteine alleviates neurodegeneration and increased glutathione expression in normal and ApoE-deficient mice. J Alzheimer Dis 7, 135-138.
• Tchantchou F, Graves M, Ortiz D, Chan A, Rogers E, Shea TB (2006) S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease. J Nutr Health Aging 10, 541-544.

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Mark A. Smith, Ph.D.

• Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N (1996) Oxidative damage in Alzheimer’s. Nature 382, 120-121.
• Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, Petersen RB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer’s disease. J Neurosci 21, 3017-3023.
• Smith MA, Perry G, Atwood CS, Bowen RL (2003) Estrogen replacement and risk of Alzheimer disease. JAMA 289, 1100.
• McShea A, Lee HG, Vincent I, Linford NJ, Funk J-O, Shapiro RA, Smith MA (2007) Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochim Biophys Acta 1772, 467-472.

Thamarapu Srikrishnan, Ph.D.

• Schuster D, Rajendran A, Hui SW, Nicotera, T, Srikrishnan T, Kruzel ML (2005) Protective effect of Colostrinin on neuroblastoma cell survival is due to reduced aggregation of β-amyloid. Neuropeptide 39, 419-426.
• Parry S, Todorova-Balvay D, Srikrishnan T, Sulkowski E (2006) Thiophilic interaction chromatography (TIC) of Alzheimer's β-amyloid peptides. J Pep Res Suppl 1, 99-105.
• Bourhim M, Kruzel M, Srikrishnan T, Nicotera T (2007) Thioflavin T as a fluorescent reporter for Aβ aggregation. J Neuroscience Methods 160, 264-268.
• Bourhim M, Johnson T, Oystin D, Srikrishnan T (2007) Thiophilic interaction chromatography (TIC) of amyloid-β protein precursor. J Alzheimers Dis 12, 143-149.

Takeshi Tabira, M.D., Ph.D.

• Chui D-H, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T (1999) Aged transgenic mice carrying Alzheimer's presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nature Medicine 5, 560-564.
• Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T (2004) Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer’s disease. J Alzheimers Dis 6, 483-488. (Alzheimer Award 2005)
• Lakshmana MK, Araki W, Tabira T (2005) Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. FASEB J 19, 1362-1364.
• Mouri A, Noda Y, Hara H, Mizoguchi H, Tabira T, Nabeshima T (2007) Oral vaccination with a recombinant adeno-associated viral vector attenuates age-related Abeta accumulation and memory deficits without lymphocytic infiltration in Tg2576 mice. FASEB J 21, 2135-2148.

Nadezda Urosevic, Ph.D.

• Stoddart CW, Martin-Iverson MT, Jablensky A, Urosevic N (2004) A novel mouse Chr5 locus Diht controls dopamine-induced hypothermia. Mammalian Genome 15, 901-913.
• Pantelic L, Sivakumaran H, Urosevic N (2005) Differential induction of antiviral effects against West Nile virus in primary mouse macrophages derived from flavivirus susceptible and congenic resistant mice by interferon type I and poly IC. J Virol 79, 1753-1764.
• Urosevic N, Pantelic L (2008) RNA Interference – The role of siRNAs as alternative antiviral agents. Malaysian J Pathol, in press.
• Urosevic N, Martins RN (2008) Infection and Alzheimer’s disease – the apoE e4 connection and lipid metabolism. J Alzheimers Dis, in press.

Teri L. Wadsworth, Ph.D.

• Wadsworth TL, Koop DR (2001) Effects of Ginkgo biloba extract (EGb 76 1) and quercetin on lipopolysaccharide-induced release of nitric oxide. Chem Biol Int 137,43-58.
• Wadsworth TL, Poonyagariyagorn K, Sullivan E, Koop DR, Roselli CE (2003) In vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in rats. J Pharmacol Exp Ther 306 187-194.
• Wadsworth TL, Carroll JM, Roberts CT, Roselli CE (2004) Saw palmetto extract suppresses IGF-I signaling and induces SAPK/JNK phosphorylation in human prostate epithelial cells. Endocrinology 145, 3205-3214.
• Wadsworth TL, Worstell TL, Roselli CE (2007) Effects of dietary saw palmetto extract on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP). Prostate 67, 661-673.

Dengshun Wang, MD, Ph.D.

• Wang DS, Iwata N, Hama E, Saido TC, Dickson DW (2003) Oxidized neprilysin in aging and Alzheimer's disease brains. Biochem Biophys Res Commun 310, 236-241.
• Farrer M, Kachergus J, Forno L, Lincoln S, Wang DS, Hulihan M, Maraganore D, Gwinn-Hardy K, Wszolek Z, Dickson D, Langston JW (2004) Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol 55, 174-179.
• Mott RT, Dickson DW, Trojanowski JQ, Zhukareva V, Lee VM, Forman M, Van Deerlin V, Ervin JF, Wang DS, Schmechel DE, Hulette CM (2005) Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. J Neuropathol Exp Neurol 64, 420-42 8.
• Wang DS, Lipton RB, Katz MJ, Davies P, Buschke H, Kuslansky G, Verghese J, Younkin SG, Eckman C, Dickson DW (2005) Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. J Neuropathol Exp Neurol 64, 378-385.

Eugene D. Weinberg, Ph.D.

• Weinberg ED (2005) Iron withholding:a defense strategy. In: Weiss G et al (Eds), Anemia of Chronic Disease, Taylor & Francis, Boca Raton, pp. 255-280.
• Weinberg ED (2006) Therapeutic potential of iron chelators in diseases associated with iron mismanagement. J Pharm Pharmacol 58, 575-584.
• Weinberg ED (2007) Antibiotic properties and applications of lactoferrin. Curr Pharmaceut Design 13, 801-811.
• Weinberg ED (2007) Iron loading in humans: a risk factor for enhanced morbidityand mortality. J Nutr Environ Med 16, 43-57.

Dr. Paolo Zatta

• Ricchelli F, Buggio R, Drago D, Salmona M, Forloni G, Negro A, Tognon G, Zatta P (2006) Aggregation/fibrillogenesis of recombinant human prion protein and Gerstmann-Sträussler-Scheinker disease peptides in the presence of metal ions. Biochemistry 45, 6724-6732.
• Banks WA, Niehoff ML, Drago D, Zatta P (2006) Aluminum complexing enhances amyloid beta protein penetration of blood-brain barrier. Brain Res 1116, 215-221.
• Ricchelli F, Fusi P, Tortora P, Valtorta M, Riva M, Tognon G, Chieregato K, Bolognin S, Zatta P (2007) Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis. Int J Biochem Cell Biol 39, 966-977.
• Zatta P, Frank A (2007) Copper deficiency and neurological disorders in man and animals. Brain Res Rev 54, 19-33.

Prof. Inga Zerr

• Sanchez-Juan P, Green A, Ladogana A, Cuadrado-Corrales N, Sánchez-Valle R, Mitrova E, Stoeck K, Sklaviadis T, Kulczycki J, Hess K, Bodemer M, Slivarichová D, Saiz A, Calero M, Ingrosso L, Knight R, Janssens ACJW, van Duijn C, Zerr I (2006) CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology 67, 637-643.
• Heinemann U, Krasnianski A, Meissner B, Varges D, Bartl M, Stoeck K, Kallenberg K, Schulz-Schaeffer WJ, Steinhoff BJ, Kretzschmar HA, Zerr I (2007) Creutzfeldt-Jakob disease in Germany: a prospective 12-years surveillance. Brain 1330, 1350-1359.
• Krasnianski A, von Ahsen N, Heinemann U, Meissner B, Kretzschmar HA, Armstrong V, Zerr I (2008) ApoE distribution and family history in genetic prion diseases  in Germany. J Mol Neurosci 34, 45-50.
• Gmitterová K, Heinemann U, Bodemer M, Krasnianski A,  Meissner B, Kretzschmar HA,  Zerr I (2008) 14-3-3 CSF levels in sporadic Creutzfeldt-Jakob disease differ across molecular subtypes. Neurobiol Aging, in press.

Henrik Zetterberg, M.D., Ph.D.

• Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer's disease. Lancet 368, 387-403.
• Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L (2006) Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 5, 228-234.
• Zetterberg H, Campbell WA, Yang HW, Xia W (2006) The cytosolic loop of the gamma-secretase component presenilin enhancer 2 (Pen-2) protects zebrafish embryos from apoptosis. J Biol Chem 281, 11933-11939.
• Zetterberg M, Landgren S, Andersson ME, Palmér MS, Gustafson DR, Skoog I, Minthon L, Thelle DS, Wallin A, Bogdanovic N, Andreasen N, Blennow K, Zetterberg H (2007) Association of complement factor H Y402H gene polymorphism with Alzheimer’s disease. Am J Med Genet, in press.

Xiongwei Zhu, Ph.D.

• Zhu X, Raina AK, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA (2000) Activation of p38 pathway links tau phosphorylation, oxidative stress and cell cycle related events in Alzheimer disease. J Neuropathol Exp Neurol 59, 880-888.
• Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA (2001) Activation and re-distribution of JNK/SAPK in Alzheimer disease. J Neurochem 76, 435-441.
• Zhu X, Raina AK, Perry G, Smith MA (2004) Alzheimer disease: the two hit hypothesis. Lancet Neurology 3, 219-226.
• Zhu X, Raina AK, Shimohama S, Perry G, Smith MA (2004) Bcl-w plays a neuroprotective role in Alzheimer disease. J Neurochem 89, 1233-1240.

Ping-Ping Zuo, M.D., Ph.D.

• Li X, Zuo P (2005) Effects of Abeta25-35 on neurogenesis in the adult mouse subventricular zone and dentate gyrus. Neurol Res 27, 218-222.
• Kong LN, Zuo PP, Mu L, Liu YY, Yang N (2005) Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease. Acta Pharmacol Sin 26, 666-672.
• Zhang Q, Huang Y, Li X, Cui X, Zuo P, Li J (2005) GM1 ganglioside prevented the decline of hippocampal neurogenesis associated with D-galactose. Neuroreport 16, 1297-1301.
• Yue Y, Hu L, Tian QJ, Jiang JM, Dong YL, Jin ZY, Cheng YH, Hong X, Ge QS, Zuo PP (2007) Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes. Acta Pharmacol Sin 28, 1129-1135.