JAD, Editorial Board Publications

Dr. Thomas Ala

Ala TA, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ (2002) The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer's disease. Int J Ger Psychiatry 17, 503-509.

Ala TA, Doss RC, Sullivan CJ (2004) Reversible dementia. A case of cryptococcal meningitis masquerading as Alzheimer’s disease. J Alzheimers Dis 6, 503-508.

Ala T. (2004) With difficult patients, a less definitive diagnosis can be helpful. (Guest Editorial). Am J Alzheimers Dis Other Demen 19, 79-80.

Ala TA, Berck LG, Popovich AM (2005) Using the telephone to call for help and caregiver awareness in Alzheimer disease. Alzheimer Dis Assoc Disord 19, 79-84.

Craig S. Atwood, Ph.D.

Bowen RL, Verdile G, Liu T, Perry G, Smith MA, Martins RN, Atwood CS (2004) Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-ß protein precursor and amyloid-ß deposition. J Biol Chem 279, 20539-20545.

Liu T, Perry G, Chan HW, Verdile G, Martins RN, Smith MA, Atwood CS (2004) Amyloid-ß-induced toxicity of primary neurons is dependent upon differentiation associated increases in tau and cyclin-dependent kinase 5. J Neurochem 88, 554-563.

Wilson, A.C., Salamat, S., Haasl, R.J., Roche, K.M., Karande, A., Vadakkadath Meethal, S., Terasawa, E., Bowen, R.L. and Atwood, C.S. (2006). Human extra-pituitary neurons possess GnRH I receptors that respond to GnRH by expressing luteinizing hormone. J Endocrinol 191, 651-665.

Porayette, P., Gallego, M.J., Kaltcheva, M.M., Vadakkadath Meethal, S. and Atwood, C.S. (2007). Amyloid-ß precursor protein expression and modulation in human embryonic stem cells: A novel role for human chorionic gonadotropin. Biochem Biophys Res Commun 364, 522-527.

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Jesús Ávila

Perez M, Santa-María I, Tortosa E, Cuadros R, Del Valle M, Hernández F, Moreno FJ, Avila J (2007) The role of the VQIVYK peptide in tau protein phosphorylation. J Neurochem 103, 1447-1460.

Goñi-Oliver P, Lucas JJ, Avila J, Hernández F (2007) N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation. J Biol Chem 282, 22406-22413.

Gómez-Sintes R, Hernández F, Bortolozzi A, Artigas F, Avila J, Zaratin P, Gotteland JP, Lucas JJ (2007) Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26, 2743-2754.

Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S (2007) Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. Eur J Neurosci 25, 81-86.

Brian J. Balin, Ph.D.

Little CS, Hammond CJ, MacIntyre A, Balin BJ, Appelt DM (2004) Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice. Neurobiol Aging 25, 419-429.

Itzhaki RF, Wozniak MA, Appelt DM, Balin BJ (2004) Infiltration of the brain by pathogens causes Alzheimer's disease. Neurobiol Aging 25, 619-627.

Little CS, Bowe A, Lin R, Litsky J, Balin BJ, Fresa-Dillon KL (2005) Age alterations in extent and severity of experimental intranasal infection by Chlamydophila pneumoniae in BALB/c mice. Infect Immun 73, 1-12.

Gerard HC, Dreses-Werringloer U, Wildt KS, Oszust C, Balin BJ, Frey II WH, Bordayo EZ, Whittum-Hudson JA, Hudson AP (2006) Chlamydophila (Chlamydia) pneumoniae in the Alzheimer’s brain. FEMS Immunol Med Micro 48, 355-366.

Thomas Bayer, Ph.D.

Bayer TA , Schäfer S, Simons A, Kemmling, Kamer T, Tepest R, Eckert A, Schüssel K, Eikenberg O, Sturchler-Pierrat, Abramowski D, Staufenbiel, Multhaup G (2003) Dietary Cu stabilizes brain SOD-1 activity and reduces amyloid Aß production in APP23 transgenic mice. PNAS 100, 14187-14192.

Schmitz C, Rutten BPF, Pielen A, Schäfer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Korr H, Steinbusch HWM, Pradier L, Bayer TA (2004) Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol 164, 1495-1502.

Wirths O, Czech C, Feldmann F, Blanchard V, Tremp G, Multhaup G, Beyreuther K, Pradier L, Bayer TA (2002) Intraneuronal APP/Abeta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. Brain Pathol 12, 275-286.

Wirths O, Multhaup G, Bayer TA (2004) A modified ß-amyloid hypothesis: intraneuronal accumulation of the ß-amyloid peptide The first step in a fatal cascade. J Neurochem 91, 513-520.

Lynn M. Bekris, Ph.D.

Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD (2007) A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. Brain 130(Pt 5), 1360-1374.

Bekris LM, Millard S, Galloway NM, Vuletic S, Albers JJ, Li G, Galasko DR, DeCarli C, Farlow MR, Clark CM, Quinn JF,Kaye JA, Schellenberg GD, Tsuang D, Peskind ER, Yu CE (2008) Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels. J Alzheimers Dis, in press

Angelika Bierhaus, Ph.D.

Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert P, Chen J, Hong M, Luther T, Henle T, Klöting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith MA, Perry G, Schmidt AM, Stern DM, Häring HU, Schleicher E, Nawroth PP (2001) Diabetes-associated sustained activation of the transcription factor NF-kB. Diabetes 50, 2792-2809.

Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, Ferstl R, von Eynatten M, Wendt Th, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwen B, Kirschbaum C, Nawroth PP (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci 100, 1920-1925.

Bierhaus A, Haslbeck KM, Humpert PM, Liliensiek B, Dehmer T, Morcos M, Sayed AA, Andrassy M, Schiekofer S, Schneider J, Schulz J, Heuss D, Neundörfer B, Dierl S, Huber J, Tritschler H, Schmidt AM, Schwaninger M, Häring HU, Schleicher E, Stern DM, Kasper M, Arnold B, Nawroth PP (2004) Loss of pain perception in diabetic neuropathy is dependent on a receptor of the immune globulin superfamily. J Clin Invest 114, 1741- 1751.

Bierhaus A, Nawroth PP (2005) Posttranslational modification of lipoproteins - a fatal attraction in metabolic diseases? J Alzheimers Dis 7, 315-317.

Garth Bissette, Ph.D.

Bissette G, Smith WH, Dole KC, Crain B, Ghanbari H, Miller B, Nemeroff CB (1991) Alterations in Alzheimer's disease-associated protein in Alzheimer's disease frontal and temporal cortex. Arch Gen Psychiatry 48, 1009-1012.

Slotkin TA, Nemeroff CB, Bissette G, Seidler FJ (1994) Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's Disease: Evidence from rapid autopsy studies. J Clin Invest 94, 696-702.

Bissette G, Cook L, Smith W, Dole KC, Crain B, Nemeroff CB (1998) Regional neuropeptide pathology in Alzheimer’s disease: Corticotropin-releasing factor and Somatostatin. J Alzheimers Dis 1, 91-105.

Horgan J, Miguel-Hidalgo J, Thrasher M, Bissette G (2007) Longitudinal brain corticotropin-releasing factor and ssomatostatin in a transgenic mouse (Tg2576) model of Alzheimers disease. J Alzheimers Dis 12, 115-127.

Professor Alexander Boldyrev

Boldyrev A, Johnson P (2002) Histidine containing dipeptides as natiral protectors against oxidative stress. In: Oxidative Stress at Molecular, Cellular and Organ Levels. Johnson P, Boldyrev A, Eds., 101-113.

Boldyrev A, Bulygina E, Carpenter D, Schoner W (2003) Glutamate receptors communicate with Na/K-ATPase in rat cerebellum granule cells. J Mol Neurosci 21, 213-222.

Boldyrev A, Kazey V, Leinsooa T, Mashkina A, Tyulina O, Johnson P, Tuneva J, Chittur S, Carpenter D (2004) Rodent lymphocytes express functionally active glutamate receptors. Biochem Biophys Res Commun 324, 133-139.

Boldyrev A, Beresov T, Koudinov A, Carpenter D (2004) Amyloid ß induced cell death is independent of free radicals. J Alzheimers Dis 6, 584-589.

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Dale E. Bredesen, M.D.

Lu DC, Rabizadeh S, Chandra S, Shayya RF, Tenney KA, Ellerby LM, Krajewski S, Ye X, Salvesen GS, Koo EH, Bredesen DE (2000) A second cytotoxic proteolytic peptide derived from beta-amyloid precursor protein. Nature Med 6, 397-404.

Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE (2006) Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. Proc Natl Acad Sci USA 103, 7130-7135.

Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH and Heinemann SF (2006) Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci 26, 13428-13436.

Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH (2006) Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). Faseb J 20, 1254-1256.

D. Allan Butterfield, Ph.D.

Butterfield DA, Poon HF, St. Clair D, Keller JN, Pierce WM, Klein JB, Markesbery WR (2006) Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease. Neurobiol Dis 22, 223-232.

Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA (2006) Oxidative modification and down-regulation of Pin 1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol Aging 27, 918-925.

Butterfield DA, Reed T, Newman SF, Sultana R (2007) Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med 43, 658-677.

Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA (2008) Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging 29, 51-70.

Frederic Calon

Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM (2004) Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43, 633-645.

Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy SA, Cole GM (2005) A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25, 3032-3040.

Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM (2006) Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci 9, 234-242.

Bousquet M, Saint-Pierre M, Julien C, Salem NJ, Cicchetti F, Calon F (2008) Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease. FASEB J 22, in press

Cynthia M. Carlsson, MD, MS

Carlsson CM, Gleason CE, Asthana S (2005) Alzheimer disease: Update on diagnosis and treatment. Consultant 45, 77-88.

Ward MA, Carlsson CM, Trivedi MA, Sager MA, Johnson SC (2005) The effect of body mass index on global brain volume in middle-aged adults: a cross-sectional study. BMC Neurology 5, 23.

Johnson SC, Schmitz TW, Trivedi MA, Ries ML, Torgerson BM, Carlsson CM, Asthana S, Hermann BP, Sager MA (2006) The influence of AD family history and ApoE4 on mesial temporal lobe activation. J Neurosci 26, 6069-6076.

Johnson SC, Ries ML, Hess TM, Carlsson CM, Gleason CE, Alexander AL, Rowley HA, Asthana S, Sager MA (2007) Alzheimer disease risk in healthy middle-aged adults affects brain function during self appraisal. Arch Gen Psychiatry 64, 1163-1171.

David O. Carpenter, M.D.

Tan Y, Chen C-H, Lawrence D, Carpenter DO (2004) Ortho-substituted PCBs kill cells by altering membrane structure. Toxicol Sci 80, 54-59.

Tan Y, Song R, Lawrence D, Carpenter DO (2004) Ortho-substituted but not coplanar PCBs rapidly kill cerebellular granule cells. Toxicol Sci 79, 147-156.

Boldyrev AA, Koudinov A, Berezov T, Carpenter DO (2004) Amyloid-β induced cell death is independent of free radicals. J Alzheimers Dis 6, 633-638.

Tuneva J, Chittur S, Boldyrev AA, Birman I, Carpenter DO (2006) Cerebellar granule cell death induced by aluminum. Neurotox Res 9, 297-304.

Rudy J. Castellani, M.D.

Castellani RJ, Zhu X, Lee HG, Moreira PI, Perry G, Smith MA (2007) Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees? Expert Rev Neurother 7, 473-485.

Castellani RJ, Honda K, Moreira PI, Liu Q, Siedlak SL, Zhu X, Smith MA, Perry G (2007) Redox active iron at the center of oxidative stress in Alzheimer disease. Neurochem Res 32, 1640-1645.

Castellani RJ, Marlatt M, Webber KM, Moreira PI, Lee H, Casadesus G, Honda K, Zhu X, Perry G, Smith MA (2008) Thinking outside the box in Alzheimer disease treatment. In Development of Therapeutic Agents, Gad S (Ed), John Wiley and Sons, in press.

Castellani RJ, Lee H, Zhu X, Nunomura A, Perry G, Smith MA (2008) Alzheimer’s disease: pathology vs. etiology. Int J Neuroprot Neuroregen, in press.

Dr. Matthew R. Chapman

Chapman MR, Robinson LS, Pinkner JS, Roth R, Heuser J, Hammar M, Normark S, Hultgren SJ (2002) Role of Escherichia coli curli operons in directing amyloid fiber formation. Science 295, 851-855.

Barnhart MM, Chapman MR (2006) Curli biogenesis and function. Annu Rev Microbiol 60, 131-147.

Hammer ND, Schmidt JC, Chapman MR (2007) The curli nucleator protein, CsgB, contains an amyloidogenic domain that directs CsgA polymerization. Proc Natl Acad Sci U S A 104, 12494-12499.

Wang X, Smith DR, Jones JW, Chapman MR (2007) In vitro polymerization of a functional Escherichia coli amyloid protein. J Biol Chem 282, 3713-3719.

Ved Chauhan, Ph.D.

Chauhan, VPS, Chauhan A, Wegiel J (2001) Fibrillar amyloid beta-protein forms a membrane-like hydrophobic domain. NeuroReport 3, 587-590.

Chauhan V, Sheikh AM, Chauhan A, Spivack WD, Fenko MD, Malik MN (2005) Fibrillar amyloid beta-protein inhibits the activity of high molecular weight protease, and trypsin. J Alzheimers Dis 7, 37-44.

Chander H, Chauhan A, Wegiel J, Malik M, Sheikh A, Chauhan V (2006) Binding of trypsin to fibrillar amyloid beta-protein. Brain Res 1082, 173-181.

Chauhan V, Chauhan A (2006) Oxidative stress in Alzheimer's disease. Pathophysiology 13, 195-208.

Muhammad Omar Chohan, M.D.

Chohan MO, Haque N, Alonso A, El-Akkad E, Grundke-Iqbal I, Grover A, Iqbal K (2005) Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau. J Neural Transm 112, 1035-1047.

Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta 1739, 198-210.

Chohan MO, Iqbal K (2005) Estrogens for the Brain. Alzheimer Research Forum, July 28, 2005, http://www.alzforum.org/pap/annotation.asp?powID=45893.

Chohan MO, Khatoon S, Grundke-Iqbal I, Iqbal K (2006) Involvement of I2pp2a in the abnormal hyperphosphorylation of tau and its reversal by memantine. FEBS Lett 580, 3973-3979.

Dr. James R. Connor

Zecca L, Youdim MBH, Riederer P, Connor JR, Crichton RR (2004) Iron, brain aging and neurodegenerative disorders. Nature Rev Neurosci 5, 863-873.

Lee S, Connor JR (2006)Regulation of Hfe by stress factors in BV-2 cells. Neurobiol Aging 26, 803-812.

Connor JR, Lee SY (2006) HFE mutations and Alzheimer’s Disease. J Alzheimers Dis 10, 267-276.

House MJ, St. Pierre TG, Kowdley K, Montine T, Connor JR, Beard J, Siddaiah N, Berger J, Shankland E, Jin LW (2007) Correlation of proton transverse relaxation rates (r2) with Iron concentrations in post-mortem brain tissue from Alzheimer’s disease patients. Magnet Reson Med 57, 172-180.

Dr. Eliecer Coto Garcia

Alvarez V, Mata IF, González P, Lahoz CH, Martínez C, Peña J, Guisasola LM, Coto E (2002) Association between the TNFα-308 A/G polymorphism and the onset-age of Alzheimer disease. Am J Med Genet 114, 574-577.

Huerta C, Alvarez V, Mata IF, Coto E, Ribacoba R, Martínez C, Blázquez M, Guisasola LM, Salvador C, Lahoz CH, Peña J (2004) Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease. Neurosci Lett 370, 151-154.

Huerta C, Castro MG, Coto E, Blázquez M, Ribacoba R, Guisasola LM, Salvador C, Martínez C, Lahoz CH, Alvarez V (2005) Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population. J Neurol Sci 236, 49-54.

González P, Alvarez V, Menéndez M, Lahoz CH, Martínez C, Corao AI, Calatayud MT, Peña J, García-Castro M, Coto E (2007) Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms. Neurosci Lett 411, 47-51.

Peter Davies, Ph.D.

Andorfer CA, Acker CM, Kress Y, Hof PR, Duff K, Davies P (2005) Cell cycle re-entry and cell death In transgenic mice expressing non-mutant human tau isoforms. J Neurosci 25, 5446-5454.

de Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segala S, Rusinek H, Lia J, Tsui W, Saint Louis LA, Clark CM, Tarshish C, Lia Y, Lair L, Javier E, Rich K. Lesbre P. Mosconi L. Reisberg B. Sadowski M. DeBernadis JF. Kerkman DJ. Hampel H. Wahlund L-O. Davies P (2006) Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging 27, 394-401.

d'Abramo C, Ricciarelli R, Pronzato MA, Davies P (2006) Troglitazone, a Poroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells. J Neurochem 98, 1068-1077.

Park KHJ, Hallows JL, Chakrabarty P, Davies P, Vincent I (2007) Conditional neuronal SV40 T Antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci 27 2969-2978.

Suzanne de la Monte, M.D.,M.P.H.

Etiene D, Kraft J, Ganju N, Gomez-Isla T, Gemelli B, Hyman BT, Hedley-Whyte ET, Wands JR, De La Monte SM (1998) Cerebrovascular pathology contributes to the heterogeneity of Alzheimer's disease. J Alzheimers Dis 1, 119-134.

de la Monte SM, Wands JR (2001) The AD7c-NTP neuronal thread protein biomarker for detecting Alzheimer's disease. J Alzheimers Dis 3, 345-353.

de la Monte SM, Chiche J, von dem Bussche A, Sanyal S, Lahousse SA, Janssens SP, Bloch KD (2003) Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration. Lab Invest 83, 287-298.

de la Monte SM, Tong M, Lester-Coll N, Plater M Jr, Wands JR (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J Alzheimers Dis 10, 89-109.

Jack C. de la Torre, M.D., Ph.D.

de la Torre JC (Ed) (2006) Special Issue: Impact of Heart Disease and Stroke on Alzheimer’s Disease. Neurol Res 28(6).

Obrenovich ME, Siedlak SL, Smith MA, Chen S, de la Torre JC, Perry G, Aliev G (2006) Overexpression of GRK2 in Alzheimer disease and in a chronic hyperperfusion rat model is an early marker of brain mitochondrial lesion. Neurotox Res 10, 43-56.

de la Torre JC (2007) Vascular pathways to Alzheimer’s disease. Dementia Forum 2, 2-6.

de la Torre JC (2008) Pathophysiology of neuronal energy crisis in Alzheimer’s disease. Neurodegenerative Dis 5, 126-132.

Alexandre Valério de Mendonça

Rebola N, Sebastião AM, de Mendonça A, Ribeiro JA, Oliveira CR, Cunha RA (2003) Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. J Neurophysiol 90, 1295-1303.

Rebola N, Coelho JE, Costenla AR, Lopes LV, Parada A, Oliveira CR, Soares da Silva P, de Mendonça A, Cunha RA (2003) Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. Eur J Neurosci 18, 820-828.

Almeida T, Rodrigues RJ, de Mendonça A, Ribeiro JA, Cunha RA (2003) Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Neuroscience 122, 111-121.

de Mendonça A, Guerreiro M, Ribeiro F, Mendes T, Garcia C (2004) Mild cognitive impairment: focus on the diagnosis. J Mol Neurosci 23, 13-17.

Dr. Justo Garcia de Yebenes

Gomez-Tortosa E, Gonzalo I, Fanjul S, Sainz MJ, Cantarero S, Cemillan C, Yebenes JG, del Ser T (2003) Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease. Arch Neurol 60, 1218-1222.

Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, Llorens V, Gomez Tortosa E, del Ser T, Munoz DG, de Yebenes JG (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55, 164-173.

Ros R, Thobois S, Streichenberger N, Kopp N, Sanchez MP, Perez M, Hoenicka J, Avila J, Honnorat J, de Yebenes JG (2005) A new mutation of the {tau} gene, G303V, in early-onset familial progressive supranuclear palsy. Arch Neurol 62, 1444-1450.

Menenedez J, Rodriguez rroJA, Solano RM, Casarejos MJ, Rodal I, Guerrero R, Sanchez M, Avila J, Mena MA, de Yebenes JG (2006) Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau. Human Mol Genet 15, 2045-2058.

Sara M. Debanne, Ph.D.

Petot GJ, Traore F, Debanne SM, Lerner AJ, Friedland RP (2003) Interactions of Apolipoprotein E Genotype and Dietary Fat Intake of Healthy Older Persons During Mid-Adult Life. Metabolism 52, 279-281.

Mizrahi EH, Jacobsen DW, Debanne SM, Traore F, Lerner AJ, Friedland RP, Petot GJ (2003) Plasma Total Homocysteine Levels, Dietary Vitamin B6 and Folate Intake in AD and Healthy Aging. J Nutrition Health Aging 7, 160-165.

Lindstrom HA, Fritsch T, Petot G, Smyth KA, Chen CH, Debanne SM, Lerner AJ, Friedland RP (2005) The relationships between television viewing in midlife and the development of Alzheimer disease in a case-control study. Brain Cogn 58, 157-165.

Debanne SM, Bielefeld RA, Cheruvu V, Fritsch T, Rowland DY (2007) Association of Alzheimer Disease and Smoking: Bias in Cohort Studies. J Alzheimers Dis 11, 313-321.

Jon Dobson, Ph.D.

Hautot D Pankhurst QA, Kahn N, Dobson J (2003) Preliminary evaluation of nanoscale biogenic magnetite and Alzheimer's disease. Proc Royal Soc B Biol Lett 270, S62-S64.

Collingwood JF, Mikhailova A, Davidson M, Batich C, Streit WJ, Terry J, Dobson J (2005) In-situ characterization and mapping of iron compounds in Alzheimer's tissue. J Alzheimers Dis 7, 267-272.

Khan A, Dobson J, Exley C (2006) The redox cycling of Fe(II) by Aβ42. Free Radic Biol Med 40, 557-569.

Collingwood JF, Dobson J (2006) Mapping and characterization of iron compounds in Alzheimer's tissue. J Alzheimers Dis 10, 215-222.

Peter R. Dodd, Ph.D.

Tsai VW-W, Scott HL, Lewis RJ, Dodd PR (2005) The role of Group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease. Neurotox Res 7, 125-141.

Tannenberg RK, Scott HL, Tannenberg AEG, Dodd PR (2006) Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE µ4. Neurochem Int 49, 631-639.

Walton HS, Dodd PR (2007) Glutamate-glutamine cycling in Alzheimer's disease. Neurochem Int 50, 1052-1066.

Agarwal S, Tannenberg RK, Dodd PR (2008) Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer disease. J Alzheimers Dis, in press.

Dr. Valeria Drago

Drago V, Foster PS, Trifiletti D, FitzGerald DB, Crucian GP, Heilman KM (2006) "What's Inside the Art?" The influence of fronto-temporal dementia in art production. Neurology 67, 1285-1287.

Drago V, Grucian GP, Pisani F, Heilman KM (2006) Distribution of attention as a Function of spatial location: right left; up-down. J Int Neuropsychol Soc 12, 532-537.

Drago V, Foster FS, Ferri R, Arico D, Heilman KM (2008) Distractibility and Alzheimer disease. The "neglected" phenomenon. J Alzheimers Dis, in press.

Professor Murat Emre

Lippa CF, Emre M (2006) Characterizing clinical phenotypes: the Lewys in their life or the life of their Lewys? Neurology 67, 1910-1911.

Sahin HA, Emre M, Ziabreva I, Perry E, Celasun B, Perry R (2006) The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol (Berl) 111, 115-125.

Sahin HA, Gurvit IH, Emre M, Hanagasi HA, Bilgic B, Harmanci H (2006) The attitude of elderly lay people towards the symptoms of dementia. Int Psychogeriatr 18, 251-258.

Aarsland D, Bronnick K, Ehrt U, De Deyn PP, Tekin S, Emre M, Cummings JL (2007) Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry 78, 36-42.

Adnan Erol, M.D.

Erol A (2007) Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stress. Bioessays 29, 811-818.

Erol A (2007) Interleukin-6 (IL-6) is still the leading biomarker of the metabolic and aging related disorders. Med Hypotheses 69, 708.

Erol A (2007) The functions of PPARs in aging and longevity. PPAR Res, doi:10.1155/2007/39654.

Erol A (2007) Muscle-Specific PPARb/d agonism may provide synergistic benefits with life style modifications. PPAR Res, doi:10.1155/2007/30578.

Dr. Christopher Exley

Exley C, Korchazhkina O, Job D, Strekopytov S, Polwart A & Crome P (2006) Non-invasive therapy to reduce the body burden of aluminium in Alzheimer’s disease. J Alzheimers Dis 10, 17-24.

Exley C (2006) Aluminium and iron, but neither copper nor zinc, are key to the precipitation of β-sheets of Aβ42 in senile plaque cores in Alzheimer’s disease. J Alzheimers Dis 10, 173-177.

Exley C, Esiri M (2006) Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK. J Neurol Neurosurg Psychiatr 77, 877-879.

Khan A, Dobson J, Exley C (2006) The redox cycling of iron by Aβ42. Free Radic Biol Med 40, 557-569.

Milan Fiala, M.D.

Fiala M, Lin J, Kermani-Arab V, Ringman J, Gustavson A, Sayre J, Lossinsky AS, Sofroni E, Graves MC, Chiappelli F, Bernard G (2005) Defective phagocytosis of amyloid-β by macrophages of Alzheimer’s disease patients. J Alzheimers Dis 7, 221-232.

Zhang L, Fiala M, Sayre J, Espinosa A, Mahanian M, Badmaev V, Graves M, Bernard G (2006) Curcuminoids enhance phagocytosis of amyloid-beta by macrophages of Alzheimer’s disease patients. J Alzheimers Dis 10, 1-7.

Fiala M, Cribbs DH, Rosenthal M, Bernard G (2007) Phagocytosis of amyloid-β and inflammation: two faces of innate immunity in Alzheimer’s disease. J Alzheimers Dis 11, 1-7.

Fiala M, Liu P, Espinosa-Jeffrey A, Rosenthal M, Ringman J, Sayre J, Zhang L, Zaghi J, Chiang B, Dejbakhsh S, Hui J, Mahanian M, Bernard G, Cashman J (2007) Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci (USA) 104, 12849-12854.

Vincenzo Fodale, M.D

Fodale V, Quattrone D, Trecroci C, Caminiti V, Santamaria LB (2006) Alzheimer's disease and anaesthesia: implications for the central cholinergic system. Br J Anaesth 97, 445-452.

Fodale V, Mafrica F, Caminiti V, Grasso G (2006) The cholinergic system in Down's syndrome. J Intellect Disabil 10, 261-274.

Grasso G, Sfacteria A, Meli F, Passalacqua M, Fodale V, Buemi M, Giambartino F, Iacopino DG, Tomasello F (2007) The role of erythropoietin in neuroprotection: therapeutic perspectives. Drug News Perspect 20, 315-320.

Mafrica F, Fodale V (2008) Thyroid function, Alzheimer’s disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? J Alzheimers Dis, in press.

Dr. Othman Ghribi

Ghribi O, Herman MM, Forbes MS, DeWitt DA, Savory J (2001) GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation. Neurobiol Dis 8, 764-773.

Ghribi O, Herman MM, Pramoonjago P, Savory J (2003) MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATF-6 and NF-kappaB signaling pathways. J Neuropathol Exp Neurol 62, 1144-1153.

Ghribi O, Larsen B, Schrag M, Herman MM (2006) High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus. Exp Neurol 200, 460-467.

Ghribi O, Golovko MY, Larsen B, Schrag M, Murphy EJ (2006) Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. J Neurochem 99, 438-449.

Dr. Ezio Giacobini

Giacobini E (2004) Cholinesterase inhibitors: new roles and therapeutic alternatives. Pharmacol Res 50, 433-440.

Onder G, Zanetti O, Giacobini E, Frisoni GB, Bartorelli L, Carbone G, Lambertucci P, Silveri MC, Bernabei R (2005) Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial. Br J Psychiatry 187, 450-455.

Greig NH, Giacobini E, Lahiri DK (2007) Advances in Alzheimer therapy: development of innovative new strategies. Curr Alzheimer Res 4, 336-339.

Giacobini E, Becker RE (2007) One hundred years after the discovery of Alzheimer's disease. A turning point for therapy? J Alzheimers Dis 12, 37-52.

Dr. Pilar Gómez-Ramos

García Gil ML, Morán MA, Gómez-Ramos P (2001) Ubiquinated granular structures and initial neurofibrillary changes in the human brain. J Neurol Sci 192, 27-34.

Díaz-Hernández M, Torres-Peraza J, Salvatori-Abarca A, Morán MA, Gómez-Ramos P, Alberch J, Lucas JJ (2005) Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a condicional mouse model of Huntington disease. J Neurosci 25, 9773-9781.

Pérez M, Ribe E, Rubio A, Lim F, Morán M A, Gómez- Ramos P, Ferrer I, Isla M TG, Ávila J (2005) Characterization of a double (amyloid precursor protein-tau) transgenic: Tau phosphorylation and aggregation. Neuroscience 130, 339-347.

Engel T, Lucas JJ, Gómez-Ramos P, Morán MA, Ávila J, Hernández F (2006) Cooexpression of FTDP-17 tau and GSK-3β in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging 27, 1258-1268.

Cheng-Xin Gong, M.D.

Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong C-X (2004) O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease. Proc Natl Acad Sci USA 101, 10804-10809.

Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong C-X (2005) Dephosphorylation of tau by protein phosphatase 5: Impairment in Alzheimer disease. J Biol Chem 280, 1790-1796.

Liang Z, Liu F, Grundke-Iqbal I, Iqbal K, Gong C-X (2007) Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J Neurochem 103, 2462-2470.

Deng Y, Li B, Liu F, Iqbal K, Grundke-Iqbal I, Brandt R, Gong C-X (2008) Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. FASEB J 22, 138-145.

Prof. Jürgen Götz

Götz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta42 fibrils. Science 293, 1491-1495.

Götz J, Streffer JR, David D, Schild A, Hoerndli F, Pennanen L, Kurosinski P, Chen F (2004) Transgenic animal models of Alzheimer’s disease and related disorders: Histopathology, behavior and therapy. Mol Psychiatr 9, 664-683.

Chen F, Wollmer A, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J (2004) Role for glyoxalase I in Alzheimer’s disease. Proc Natl Acad Sci USA 101, 7687-7692.

David DC, Ittner LM, Gehrig P, Nergenau D, Shepherd C, Halliday G, Götz J (2006) β-Amyloid treatment of two complementary P301L tau-expressing Alzheimer’s disease models reveals similar deregulated cellular processes. Proteomics 6, 6566-6577.

John L. Goudreau, D.O., Ph.D.

Goudreau JL, Maraganore DM, Farrer MJ, Lesnick TG, Singleton AB, Hardy JA, Rocca WA (2002) Case-control study of dopamine transporter-1, monoamine oxidase-B and catechol-O-methyl transferase polymorphisms in Parkinson’s disease. Move Disord 17, 1305-1311.

Drolet RD, Behrouz B, Lookingland KJ, Goudreau JL (2006) Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of α-synuclein. J Neurochem 96, 950-959, 2006.

Duka T, Rusnak M, Drolet RE, Duka V, Wersinger C, Goudreau JL, Sidu A (2006) Alpha-synuclein induces the hyperphosphorylation of tau in the MPTP model of parkinsonism. FASEB J 20, 2302-2312.

Behrouz D, Drolet RE, Sayed ZA, Lookingland KJ, Goudreau JL (2007) Unique responses to mitochondrial complex I inhibition in tuberoinfundibular dopamine neurons may impart resistance to toxic insult. Neuroscience 147, 592-598.

Prof. Stefano Govoni

Lanni C, Uberti D, Racchi M, Govoni S, Memo M (2007) Unfolded p53: a potential biomarker for Alzheimer's disease. J Alzheimers Dis 12, 93-99.

Lenzken SC, Lanni C, Govoni S, Lucchelli A, Schettini G, Racchi M (2007) Nicotinic component of galantamine in the regulation of amyloid precursor protein processing. Chem Biol Interact 165, 138-145.

Lanni C, Racchi M, Mazzini G, Ranzenigo A, Polotti R, Sinforiani E, Olivari L, Barcikowska M, Styczynska M, Kuznicki J, Szybinska A, Govoni S, Memo M, Uberti D (2007) Conformationally altered p53: a novel Alzheimer's disease marker? Mol Psychiatry, in press.

Preda S, Govoni S, Lanni C, Racchi M, Mura E, Grilli M, Marchi M (2007) Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens. Neuropsychopharmacology, in press.

Paula Grammas, Ph.D.

Hensley K, Ferrell S, Floyd RA, Gordon B, Grammas P, Mhatre M, Mou S, Pye QN, Stewart C, West M, West S, Williamson KS (2004) The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits TNFa activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem 91, 540-546.

Christov A, Ottman JT, Grammas P (2004) Vascular inflammatory, oxidative and protease-based proceses: implication neuronal cell death in Alzheimer’s disease. Neurol Res 26, 540-546.

Kanmogne GD, Primeaux C, Grammas P (2005) HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: Implications for the pathogenesis of HIV-associated dementia. J Neuropathol Exp Neurol 64, 498-505.

Kanmogne GD, Primeaux C, Grammas P (2005) Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins. Biochem Biophys Res Commun 333, 1107-1115.

Dr. Ann-Charlotte Granholm

Isacson O, Seo H, Lin L, Albeck D, Granholm AC (2002) Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25, 79-84.

Hunter CL, Bachman D, Granholm AC (2004) Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Ann Neurol 56, 675-688.

Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE (2004) Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets 5, 517-528.

Williams BJ, Eriksdotter-Jonhagen M, Granholm AC (2006) Nerve growth factor in treatment and pathogenesis of Alzheimer's disease. Prog Neurobiol 80, 114-128.

Dr. Edna Grünblatt

Luckhaus C, Spiegler C, Ibach B, Fischer P, Wichart I, Sterba N, Gatterer G, Rainer M, Jungwirth S, Huber K, Tragl KH, Grünblatt E, Riederer P, Sand P (2006) Estrogen Receptor β Gene ESRβ3'-UTR Variants in Alzheimer Disease. Alz Dis Assoc Disord 20, 322-323.

Grünblatt E, Löffler C, Zehetmayer S, Jungwirth S, Tragl KH, Riederer P*, Fischer P* (2006) Association study of the 5-HTTLPR polymorphism and depression in non-demented subjects of age 75 from the VITA study. J Clinic Psych 67, 1373-1378. (*Both authors contributed equally)

Jacob CP, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P, Grünblatt E (2007) Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer’s disease J Alzheimers Dis 11, 97-116

Grünblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101, 757-770.

Félix Hernández, Ph.D.

Engel T, Lucas JJ, Gomez-Ramos P, Moran MA, Avila J, Hernandez F (2006) Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging 27, 1258-1268.

Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2006) Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem 99, 1445-1455.

Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2007) N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation. J Biol Chem 282, 22406-22413.

Hernandez F, Avila J (2007) Tauopathies. Cell Mol Life Sci 64, 2219-2233.

Sanna-Kaisa Herukka

Herukka SK, Hallikainen M, Soininen H, Pirttilä T (2005) CSF Abeta and Tau or phosphorylated Tau and prediction of progressive mild cognitive impairment. Neurology 64, 1294-1297.

Herukka SK, Helisalmi S, Hallikainen M, Tervo S, Soininen H, Pirttilä T (2007) CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI. Neurobiol Aging 28, 507-514.

Lämsä R, Helisalmi S, Herukka SK, Tapiola T, Pirttilä T, Vepsäläinen S, Hiltunen M, Soininen H (2008) Genetic study evaluating LDLR polymorphisms and Alzheimer's disease. Neurobiol Aging, in press.

Ojala J, Alafuzoff I, Herukka SK, van Groen T, Tanila H, Helisalmi S, Pirttilä T (2008) Expression of interleukin 18 is increased in the brain of Alzheimer’s disease patients. Neurobiol Aging, in press.

Prof. Nigel M. Hooper

Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ (2003) Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 100, 11735-11740.

Vardy ERLC, Catto AJ, Hooper NM (2005) Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med 11, 464-472.

Cordy JM, Hooper NM, Turner AJ (2006) The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol 23, 111-122.

Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper HM (2007) Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci USA 104, 11062-11067.

Khalid Iqbal, Ph.D.

Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I (2005) Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Ann Neurol 58, 748-757.

Wang JZ, Grundke-Iqbal I, Iqbal K (2007) Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci 25, 59-68.

Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I (2007) Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogeneis. Neurobiol Aging 28, 1148-1162.

Chen S, Li B, Grundke-Iqbal I, Iqbal K (2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit or protein phosphatase 2A. J Biol Chem 283, 10513-10521.

Michael C. Irizarry, M.D., M.P.H.

Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC (2004) Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62, 925-931.

Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology 65, 1402-1408.

Irizarry MC, Yao Y, Hyman BT, Growdon JH, Praticò D (2007) Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease. Neurodegener Dis 4, 403-405.

Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung GY, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I, Matthews PM, Owen MJ, Plumpton M, Pryse-Phillips W, Prinjha RK, Richardson JC, Saunders A, Slater AJ, St George-Hyslop PH, Stinnett SW, Swartz JE, Taylor RL, Wherrett J, Williams J, Yarnall DP, Gibson RA, Irizarry MC, Middleton LT, Roses AD (2008) Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol 65, 45-53.

Prof. Ruth Itzhaki

Wozniak MA, Combrinc M, Wilcock GK, Itzhaki RF (2005) Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients. J Med Virol 75, 300-306.

Itzhaki RF, Wozniak MA (2006) Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer’s disease and other disorders. Progr Lipid Res 45, 73-90.

Wozniak MA, Shipley SJ, Dobson CB, Parker SP, Scott FT, Leedham-Green M, Breuer J, Itzhaki RF, (2007) Does apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus? Eur J Human Genet 15, 672-678.

Wozniak MA, Shipley SJ, Itzhaki RF, Dobson CB (2007) Herpes virus-induced amyloid deposition: a major pathway to Alzheimer’s disease. Neurosci Lett. In proof: doi:10.1016/j.neulet.2007.09.077.

Christian P. Jacob, M.D.

Jacob C, Strobel A, Hohenberger K, Ringel T, Gutknecht L, Reif A, Brocke B, Lesch KP (2004) Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders. Am J Psychiatry 161, 569-572.

Jacob C, Muller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, Schmidtke A, Mossner R, Lesch KP (2005) Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology 30, 1711-1718.

Gutknecht L*, Jacob C*, Strobel A*, Müller J, Reif A, Mössner R, Zeng Y, Gross C, Brocke B, Lesch KP (2007) Tryptophan hydroxylase-2 gene variation influences personality traits and related disorders. Int J Neuropsychopharmacol 10, 309-320. *contributed as equal.

Jacob C, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P, Grünblatt E (2007) Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer’s disease. J Alzheimers Dis 11, 97-116.
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Kurt A. Jellinger, M.D.

Jellinger KA (2006) Clinicopathological analysis of dementia disorders in the elderly--an update. J Alzheimers Dis 9, 61-70.

Jellinger KA (2007) More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains. Acta Neuropathol (Berl) 114, 299-303.

Jellinger KA, Attems J (2007) Neuropathological evaluation of mixed dementia. J Neurol Sci 257, 80-87.

Jellinger KA, Attems J (2007) Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathol 113, 107-117.

Tae H. Ji

Hone E, Martins IJ, Jeoung M, Ji TH, Grandy SE, Martins RN (2005) Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoforms specific receptor binding. J Alzheimers Dis 7, 303-314.

Youn H, Ji I, Ji HP, Markesbery WR, Ji TH (2007) Under-expression of Kalirin-7 increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. J Alzheimers Dis 12, 271-281.

Juan S. Jiménez

Benítez MJ, Mier G, Briones F, Moreno FJ, Jiménez JS (1997) A surface-plasmon-resonance analysis of polylysine interactions with a peptide substrate of protein kinase CK2 and with the enzyme. Biochemical J 324, 987-994.

Moreno FJ, Díaz-Nido J, Jiménez JS, Ávila J (1999) Distribution of CK2, its substrate MAP1B and phosphatases in neuronal cells. Mol Cell Biochem 191, 201-205.

Pérez M, Cuadros R, Benítez MJ, Jiménez JS (2004) Interaction of Alzheimer’s disease amyloid β peptide fragment 25-35 with tau protein, and with a tau peptide containing the microtubule binding domain. J Alzheimers Dis 6,461-467.

Barrantes A, rro PJ, Benítez MJ, Jiménez JS (2006) A DNA and histone immobilization method to study DNA-histone interactions by surface plasmon resonance. Anal Biochem 352, 151-153.

Gail V. W. Johnson Voll, Ph.D.

Ding H, Matthews TA, Johnson GV (2006) Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. J Biol Chem 281, 19107-19114.

Chun W, Waldo GS, Johnson GV (2007) Split GFP complementation assay: a novel approach to quantitatively measure aggregation of tau in situ: effects of GSK3beta activation and caspase 3 cleavage. J Neurochem 103, 2529-2539.

Chun W, Johnson GV (2007) Activation of glycogen synthase kinase 3beta promotes the intermolecular association of tau. The use of fluorescence resonance energy transfer microscopy. J Biol Chem 282, 23410-23417.

Chun W, Johnson GV (2007) The role of tau phosphorylation and cleavage in neuronal cell death. Front Biosci 12, 733-756.

Angela R. Kamer, DDS, MS, PhD

Kamer AR, Sacks PG, Vladutiu A, Liebow C (2004) EGF mediates multiple signals: dependence on conditions. Int J Mol Med 13, 143-147.

Kamer AR, Sirois D, Huhmaan M (2005). Bidirectional Impact of oral health and general health. In: Nutrition and Oral Medicine, Touger-Decker R, Sirois D, Mobley C (Eds). Humana Press, Inc. Totowa, New Jersey.

Kamer AR, El-Ghorab N, Marzek N, Margarone JE III, Dziak R (2006) Nicotine induced proliferation and cytokine release in osteoblastic cells. Int J Mol Med 17, 121-127.

Craig RG, Kotanko P, Kamer AR, Levin NW (2007) Periodontal diseases: A modifiable source of systemic inflammation for the end stage renal disease patient on hemodialysis therapy? Nephrology, Dialysis and Transplantation 22, 312-315.

Marian L. Kruzel, Ph.D.

Schuster D, Rajendran A, Hui SW, Nicotera T, Srikrishnan T, Kruzel ML (2005) Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of beta-amyloid. Neuropeptides 39, 419-426.

Bacsi A, Stanton J, Hughes T, Kruzel M, Boldogh I (2005) Colostrinin-driven neurite outgrowth requires p53 activation in PC12 cells. Cell Mol Neurobiol 25, 1123-1139.

Bourhim M, Kruzel M, Srikrishnan T, Nicotera T (2007) Linear quantitation of Aβ aggregation using Thioflavin T: Reduction in fibril formation by colostrinin. J Neurosci Methods 160, 264-268.

Bacsi A, Woodberry M, Kruzel ML, Boldogh I (2007) Colostrinin delays the onset of proliferative senescence of diploid murine fibroblast cells. Neuropeptides 41, 93-101.

Debomoy K. Lahiri, Ph.D.

Lahiri DK, Ge Y-W, Maloney B, Wavrant-De Vrièze F, Hardy J (2005) Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer’s disease. Neurobiol Aging 26, 1329-1341.

Lahiri DK, Maloney B, Ge Y-W (2006) Functional domains of the BACE1 and BACE 2 promoters and mechanism of transcriptional suppression of the BACE2 promoter in normal neuronal cells. J Mol Neurosci 29, 65-80.

Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu Q-S, Brossi A, Mamczarz J, Holloway HW, Furukawa K, Sambamurti K, Lahiri DK (2005) Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augements learning and lowers β-amyloid peptide in rodents. Proc Natl Acad Sci USA 102, 17213-17218.
Lahiri DK, Chen D, Maloney B, Holloway HW, Yu Q-S, Utsuki T, Giordano T, Sambamurti K, Greig NH (2007) The experimental Alzheimer’s disease drug posiphen lowers amyloid-β peptide levels in cell culture and mice. J Pharmacol Exp Ther 320, 386-396.

Christoph Laske, M.D.

Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, Soekadar S, Richartz E, Koehler N, Bartels M, Buchkremer G, Schott K (2007) BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 41, 387-394.

Laske C, Leyhe T, Stransky E, Eschweiler GW, Bueltmann A, Langer H, Stellos K, Gawaz M (2007) Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer’s disease. J Psychiatr Res, in press

Leyhe T, Stransky E, Eschweiler GW, Buchkremer G, Laske C (2008) Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer’s disease. Eur Arch Psychiatry Clin Neurosci 258, 124-128.

Laske C, Stellos K, Eschweiler GW, Leyhe T, Gawaz M (2008) Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer’s disease: a contribution to a deficient hematopoietic brain support? J Alzheimers Dis, in press.

Virginia M.-Y. Lee, Ph.D.

Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM (2005) Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 45, 847-859.

Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM (2005) BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J Cell Biol 168, 291-302.

Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 42-43.

Yoshiyama Y, Higuchi M, Zhang B, Huang S-M, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VMY (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351.

Geneviève Leuba, Ph.D.

Savioz A, Riederer BM, Heutink P, Rizzu P, Tolnay M, Kovari E, Probst A, Riederer IM, Bouras C, Leuba G (2003) Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22. Neurobiol Dis 12, 46-55.

Leuba G, Vernay A, Vu D, Walzer C, Belloir B, Kraftsik R, Bouras C, Savioz A (2004) Differential expression of LMO4 protein in Alzheimer's disease. Neuropathol Appl Neurobiol 30, 57-69.

Leuba G, Wernli G, Vernay A, Kraftsik R, Mohajeri MH, Saini KD (2005) Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease. Dement Geriatr Cogn Disord 19, 171-183.

Leuba G, Walzer C, Vernay A, Carnal B, Kraftsik R, Piotton F, Marin P, Bouras C, Savioz A. (2008) Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction. Neurobiol Dis, in press.

Dr. Min Li

Liu CL, Xie LX, Li M*, Kumar DSS, Goto S, Huang JD* (2007) Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt and Bcl-2 pathways. PlotS. ONE 2, e1321.doi:10.1371/ journal.pone.0001321. 2007.12.19 (*co-corresponding author).

Li M, Zhao MQ, Kumar DSS, Xie LX, Zhang HX, Kum WF, Goto S, Liao FL (2008) Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress. Clin Hemorhe Mecro 38, 177-187.

Kumar DSS, Yuan QJ, Xie LX, Chan WS, Kum WF, Koo I, Liu CL, Song YQ, Huang JD*, Klein WL, Li M* (2008) Salvianolic acid B inhibits Aβ fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity. Neurochem Int 52, 741-750 (*co-corresponding author).

Man SC, Kumar DSS, Kum WF, Lu JH, Huang JD, Cheng CF, Chung V, Xu M, Li M (2008) Systematic review of the efficacy and safety of herbal medicines for Alzheimer’s disease. J Alzheimers Dis, in press.

Andrew Lieberman, M.D., Ph.D.

Yu Z, Dadgar N, Albertelli M, Scheller A, Albin RL, Robins DM, Lieberman AP (2006) Abnormalities of germ cell maturation and Sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein. Am J Pathol 168, 195-204.

Thomas M, Harrell JM, Morishima Y, Peng HM, Pratt WB, Lieberman AP (2006) Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction. Hum Mol Genet 15, 1876-1883.

Yu Z, Dadgar N, Albertelli M, Gruis K, Jordan C, Robins DM, Lieberman AP (2006) Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model. J Clin Invest 116, 2663-2673.

Pacheco CD, Kunkel R, Lieberman AP (2007) Autophagy in Niemann-Pick C disease is Beclin-1 dependent and responsive to lipid trafficking defects. Hum Mol Genet 16, 1495-1503.

Miguel A. Lopez-Toledano, Ph.D.

López-Toledano MA, Shelanski M (2004) Neurogenic effect of beta-amyloid peptide in the development of Neural Stem Cells. J Neurosci 24, 5439-5444

López-Toledano MA, Redondo C, Lobo MVT, Reimers D, Herranz AS, Paino CL, Bazán E (2004) Tyrosine hydroxylase induction by basic fibroblast growth factor and cyclic AMP analogs in striatal neural stem cells: Role of ERK1/ERK2 mitogen-activated protein kinase and protein kinase C. J Histochem Cytochem 52, 1177-1191.

Perez-Olle R, Lopez-Toledano MA, Cabrera-Poch N, Stefanis L, Brown K, Liem RKH (2005) Generalized transport defects caused by neurofilament light gene mutations linked to Charcot-Marie-Tooth. J Neurochem 93, 861-874.

Redondo C, López-Toledano MA, Lobo MV, Gonzalo-Gobernado R, Reimers D, Herranz AS, Paino CL, Bazán E (2007) Kainic acid triggers oligodendrocyte precursor cell proliferation and neuronal differenation from striatal neural stem cells. J Neurosci Res 85, 1170-1182.

Dr. Yuan Luo

Wu YJ, Luo Y (2005) Transgenic C. elegans as a model in Alzheimer’s research. Curr Alzheimer Res 2, 37-45.

Wu Y, Wu ZX, Christen Y, Lambert MP, Klein ML, Link CD, Luo Y (2006) Amyloid beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26, 13102-13113.

Xu Y, Cui C, Christen Y, Luo Y (2007) Restoration of impaired phosphorylation of cyclic AMP response element binding protein (CREB) by EGb 761 and its constituents in Aβ-expressing neuroblastoma cells. Eur J Neurosci 26, 2931-2939.

Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y (2007) EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J 21, 2400-2408.

Prof. Ian G. Macreadie

Westermeyer C, Macreadie IG (2007) Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mitochondrial DNA in Candida glabrata. FEMS Yeast Res 7, 436-441.

Caine J, Sankovich S, Antony H, Waddington L, Macreadie P, Varghese J, Macreadie I (2007) Alzheimer's Aβ fused to green fluorescent protein induces growth stress and a heat shock response. FEMS Yeast Res 7, 1230-1236.

Wikhe K, Westermeyer C, Macreadie IG (2007) Biological consequences of statins in Candida species and possible implications for human health. Biochem Soc Trans 35 (Pt 6), 1529-1532.

Macreadie IG (2007) Copper transport and Alzheimer’s disease. Eur J Biophys, in press.

Michelangelo Mancuso, M.D., Ph.D.

Micheli D, Bonvicini C, Rocchi A, Ceravolo R, Mancuso M, Tognoni G, Gennarelli M, Siciliano G, Murri L (2006) No evidence for allelic association of serotonin 2a receptor and transporter gene polymorphisms with depression in Alzheimer disease. J Alzheimers Dis 10, 371-378.

Mancuso M, Nardini M, Micheli D, Rocchi A, Nesti C, Giglioli NJ, Petrozzi L, Rossi C, Ceravolo R, Bacci A, Choub A, Ricci G, Tognoni G, Manca ML, Siciliano G, Murri L (2007) Lack of association between mtDNA haplogroups and Alzheimer's disease in Tuscany. Neurol Sci 28, 142-147.

Coppede F, Mancuso M, Gerfo AL, Manca ML, Petrozzi L, Migliore L, Siciliano G, Murri L (2007) A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. Neurosci Lett 414, 282-285.

Mancuso M, Coppedè F, Siciliano G, Murri L (2007) Mitochondrial cascade hypothesis of Alzheimer’s disease: myth or reality? Antiox Redox Signal 9, 1631-1646.

Prof. G. Ali Mansoori

Mansoori GA (2007) Diamondoid molecules. In: Advances in Chemical Physics, 136, pp. 207-258.

Nikakhtar A, Nasehzadeh A, Mansoori GA (2007) Formation and stability conditions of DNA-dendrimer nano-clusters. J Comput Theor Nanosci 4, 521-528.

Mansoori GA, George ThF, Assoufid L, Zhang G, Eds. (2007) Molecular Building Blocks for Nanotechnology From Diamondoids to Nanoscale Materials and Applications. Series: Topics in Applied Physics , Vol. 109, XII, 426 p.

Nazem A, Mansoori GA (2008) Nanotechnology solutions for Alzheimer's disease: Advances in research tools, diagnostic methods and therapeutic agents. J Alzheimers Dis, 13, in press.

Dr. Ralph Martins

Laws SM, Hone E, Gandy S, Martins RN (2003) Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. J Neurochem 84, 1215-1236.

Bowen RL*, Verdile G*, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS (2004) Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-ß precursor protein and amyloid-ß deposition. J Biol Chem 279, 20539-20545. * shared first author

Verdile G, Groth D, Mathews P, St-George Hyslop PH, Fraser P, Ramabhadran TV, Kwok JBJ, Schofield PR, Carter T, Gandy S, Martins RN (2004) Baculoviruses expressing the human familial Alzheimer’s disease presenilin 1 mutation lacking exon9 increase levels of an amyloid beta-like protein in Sf9 cells. Mol Psychiatry 9, 594-602.

Burkhardt MS, Foster JK, Laws SM, Baker LD, Craft S, Gandy SE, Stuckey BGA, Clarnette R, Nolan D, Hewson-Bower B, Martins RN (2004) Oestrogen replacement therapy may improve memory functioning in the absence of APOE 4. J Alzheimers Dis 6, 221-228.

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Patrizia Mecocci, M.D., Ph.D.

Polidori MC, Mariani E, Baggio G, Deiana L, Carru C, Pes GM, Cecchetti R, Franceschi C, Senin U, Mecocci P (2007) Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity. Eur J Clin Nutr 61, 922-924.

Mariani E, Monastero R, Ercolani S, Mangialasche F, Caputo M, Feliziani FT, Vitale DF, Senin U, Mecocci P (2007) Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl Project. Dement Geriatr Cogn Disord 24, 448-456.

Polidori MC, Griffiths HR, Mariani E, Mecocci P (2007) Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids 32, 553-559.

Ravaglia G, Forti P, Montesi F, Lucicesare A, Pisacane N, Rietti E, Dalmonte E, Bianchin M, Mecocci P (2007) Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population. J Am Geriatr Soc, in press.

Dr. Jose Raul Mena Lopez

Galván M, David JP, Delacourte A, Luna J, Mena R (2001) Sequence of neurofibrillary changes in aging and Alzheimer´s disease: A confocal study with phospho-tau antibody, AD2. J Alzheimers Dis 3, 417-425.

García-Sierra F, Wischik CM, Harrington CR, Luna-Muñoz J, Mena R (2001) Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer’s disease. J Chem Neuroanat 22, 65-77.

Luna-Muñoz J, García-Sierra F, Falcón V, Menéndez I, Chávez-Macías L, Mena R (2005) Regional conformational change involving phosphorylation of tau protein at the Thr-231, precedes the structural change detected by Alz-50 antibody in Alzheimer’s disease. J Alzheimers Dis 8, 29-41.

García-Sierra F, Luna-Muñoz J, Mena-López R (2006) Fisiopatología de la Enfermedad de Alzheimer. Archivos de Neurociencias 11 (Supl. I), 34-39

Manuel Menendez-Gonzalez

Menéndez González M, García Fernández C, Antón González C, González González S, Blázquez Menes B (2005) Pérdida de memoria como motivo de consulta. Neurología 20, 390-394.

Menéndez-González M, Pérez-Pinera P, Martínez-Rivera M, Calatayud MT, Blázquez Menes B (2005) APP processing and the APP-KPI domain involvement in the amyloid cascade. Neurodegener Dis 2, 277-283.

González P, Alvarez V, Menéndez M, Lahoz CH, Martínez C, Corao AI, Calatayud MT, Peña J, García-Castro M, Coto E (2007) Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms. Neurosci Lett 411, 47-51.

Cuetos-Vega F, Menendez-González M, Calatayud-Noguera T (2007) Description of a novel test for the early detection of Alzheimer's disease. Rev Neurol 44, 469-474.

Judith Miklossy, M.D., Ph.D.

Miklossy J, Taddei K, Martins R, Escher G, Kraftsik R, Pillevuit O, Lepori D, Campiche M (1999) Alzheimer disease: curly fibers and tangles in organs other than brain. J Neuropathol Exp Neurol 58, 803-814.

Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, H Hani E, Vionnet N, Nicod P, Boutin P, Froguel P (2000) The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature Genetics 24, 291-295.

Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fisher C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN (2003) Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging 24, 655-662.

Guo J, Arai T, Miklossy J, and McGeer PL (2006) Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer disease. Proc Natl Acad Sci U S A 103, 1953-1958.

Dr. Andrei C. Miu

Miu AC, Andreescu CE, Vasiu R, Olteanu AI (2003) A behavioral and histological study of the effects of long-term exposure of adult rats to aluminum. Int J Neurosci 113, 1197-1211.

Miu AC, Olteanu AI, Miclea M (2004) A behavioral and ultrastructural dissection of the interference of aluminum with aging. J Alzheimers Dis 6, 315-328.

Miu AC (2006) The silicon link between aluminium and Alzheimer's disease. J Alzheimers Dis 10, 39-42.

Miu AC, Benga O (2006) Aluminum and Alzheimer's disease: A new look. J Alzheimers Dis 10, 179-201.

Dr. Thomas Montine

Montine TJ, Quinn J, Kaye J, Morrow JD (2007) F(2)-isoprostanes as biomarkers of late-onset Alzheimer's disease. J Mol Neurosci 33, 114-119.

Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ (2007) Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol 62, 406-413.

Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JC, Montine TJ (2007) Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 69, 878-885.

Li G, Sokal I, Quinn JF, Leverenz JB, Brodey M, Schellenberg GD, Kaye JA, Raskind MA, Zhang J, Peskind ER, Montine TJ (2007) CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment: a follow-up study. Neurology 69, 631-639.

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Paula I. Moreira, Ph.D.

Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis 12, 195-206.

Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G (2007) Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 3, 614-615.

Moreira PI, Santos MS, Oliveira CR (2007) Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal 9, 1621-1630.

Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 66, 525-532.

Vito Davide Moretti, M.D., Ph.D.

Moretti, DV, Babiloni C, Binetti G, Cassetta E, Dal Forno G, Ferreri F, Ferri R, Lanuzza B, Miniussi C, Nobili F, Rodriguez G, Salinari S, Rossini PM (2004) Individual analysis of EEG frequency and band power in mild Alzheimer’s Disease. Clin Neurophysiol 115, 299-308.

Babiloni C, Cassetta E, Dal Forno G, Del Percio C, Ferreri F, Ferri R, Lanuzza B, Miniussi C, Moretti DV, Nobili F, Pascual-Marqui RD, Rodriguez G, Romani GL, Salinari S, Zanetti O, Rossini PM (2006) Donepezil effects on sources of cortical rhythms in mild Alzheimers disease: responders vs. non responders. Neuroimage 31, 1650-1665.

Moretti DV, Miniussi C, Frisoni G, Zanetti O, Binetti G, Geroldi C, Galluzzi S, Rossini PM (2007) Vascular damage and EEG markers in subjects with mild cognitive impairment. Clin Neurophysiol 118, 1866-1876.

Moretti DV, Miniussi C, Frisoni GB, Geroldi C, Zanetti O, Binetti G, Rossini PM (2007) Hippocampal atrophy and EEG markers in subjects with mild cognitive impairment. Clin Neurophysiol 118, 2716-2729.