Volume 4, Number 3, June 2002: Guest Editor, Craig S. Atwood
Special Issue: Challenging Views of Alzheimer Disease
 

Pages 129-130
  • Forward: Challenging Views of Alzheimer’s Disease
    Organizers: Keith A. Crutcher, Stephen R. Robinson, and Mark A. Smith
      •  
    • Debate 1: Does Amyloid or its Precursor Cause Familial AD? (Moderator: Stephen Synder)
         
        Pages 133-138
      • Steve Estus, David Borchelt, Mark S. Kindy, Robert Vassar
        Aß deposition is essential to AD neuropathology
    • Debate 2: ApoE4: Is it the Absence of Good of the Presence of Bad? (Moderator: J. Wesson Ashford)
       
        Pages 141-143
      • J. Wesson Asford
        ApoE4: Is it the Absence of Good or the Presence of Bad?
        Pages 145-154
      • G. William Rebeck, Mark Kindy, Mary Jo LaDu
        Apolipoprotein E and Alzheimer’s disease: the protective effects of ApoE2 and E3
         
        Pages 155-163
      • Bruce Teter, Jacob Raber, Britto Nathan, Keith A. Crutcher
        The presence of apoE4, not the absence of apoE3, contributes to AD pathology
    • Debate 3: Is Non-Familial AD Inherited? (Moderator: Robert Petersen)
        Pages 167-168
      • Robert B. Petersen
        You can take the genome out of the organism, but can you take the organism out of the environment?
        Pages 169-177
      • J. Wesson Ashford, James A. Mortimer
        Non-familial Alzheimer’s disease is mainly due to genetic factors
         
        Pages 179-189
      • William B. Grant, Arezoo Campbell, Ruth F. Itzhaki, John Savory
        The significance of environmental factors in the etiology of Alzheimer’s disease
    • Debate 4: Fire! Are Oxidation and Inflammation the Culprits in AD? (Moderator: Hossein Ghanbari)
        Pages 193-201
      • D. Allan Butterfield, Sue Griffin, Gerald Münch, Giulio Maria Pasinetti
        Amyloid ß-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer’s disease brain exists
        Pages 203-214
      • Craig S. Atwood, Stephen R. Robinson, and Mark A. Smith
        Amyloid-ß: redox-metal chelator and antioxidant
    • Debate 5: Is AD a Vascular or a Metabolic Disorder? (Moderator: Creighton "Tony" Phelps)
        Pages 217-223
      • P Grammas, M Yamada, B Zlokovic
        The cerebromicrovasculature: a key player in the pathogenesis of AD

        Pages 225-232

      • John P Blass, Gary E Gibson, Siegfried Hoyer
        The role of the metabolic lesion in Alzheimer’s disease
    • Debate 6: Were the Tauists Right All Along? (Moderator: David Morgan)
        Pages 235-238
      • Khalid Iqbal, Inge Grundke-Iqbal
        Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease
    • Debate 7: Cyclin Towards, or Away From, Dementia? (Moderator: John Blass)
        Pages 241-242
      • John P. Blass
        Debate 7: Cyclin Towards, or Away From, Dementia?
        Pages 243-247
      • Karl Herrup, Thomas Arendt
        Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease

        Pages 249-254

      • Robert Bowser, Mark A. Smith
        Cell cycle proteins in Alzheimer’s disease:  plenty of wheels but no cycle
    • Debate 8: Promising New Directions for Drugs and Diagnostics? (Moderator: Chris Kircher)
         
        Pages 257-260
      • Dave Morgan and R. Kennedy Keller
        What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer's disease

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