%0 Journal Article %J J Alzheimers Dis %D 2016 %T Alcohol Consumption and Incident Dementia: Evidence from the Sydney Memory and Ageing Study. %A Heffernan, Megan %A Mather, Karen A %A Xu, Jing %A Assareh, Amelia A %A Kochan, Nicole A %A Reppermund, Simone %A Draper, Brian %A Trollor, Julian N %A Sachdev, Perminder %A Brodaty, Henry %X

Alcohol consumption is a potentially modifiable risk factor for dementia, but the literature is not completely consistent. This inconsistency may be partly due to an interaction with the apolipoprotein E (APOE) genotype, an established risk factor for Alzheimer's dementia. The aim of this study was to examine whether alcohol consumption is associated with incident dementia or decline in specific cognitive domains over 4 years, and if this effect is modified by APOEɛ4 status. Non-demented community dwelling older adults (70-90 years) from an ongoing longitudinal study were assessed for cognitive impairment in attention/processing speed, language, executive function, visuospatial ability, and memory. Incident dementia was diagnosed according to DSM-IV criteria. Compared to those who did not drink in the previous 12 months, neither low consumption (HR 0.64 95% CI 0.3-1.4) or risky consumption (HR 0.58 95% CI 0.2-1.5) was associated with incident dementia. Carriers of the APOEɛ4 allele were more likely to develop dementia, but there was no significant interaction with alcohol consumption.

%B J Alzheimers Dis %V 52 %P 529-38 %8 2016 Mar 29 %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/27031466?dopt=Abstract %R 10.3233/JAD-150537