%0 Journal Article %J J Alzheimers Dis %D 2018 %T Meta-Analysis of the Association between Variants in ABCA7 and Alzheimer's Disease. %A Ma, Fang-Chen %A Wang, Hui-Fu %A Cao, Xi-Peng %A Tan, Chen-Chen %A Tan, Lan %A Yu, Jin-Tai %X

The ATP-binding cassette transporter A7 (ABCA7) was identified as a known risk factor for Alzheimer's disease (AD). However, the relation between ABCA7 and AD was still inconsistent across these studies. Here, our meta-analysis aimed at confirming the association of ABCA7 with AD. Finally, 16 case-control studies (63747 versus 85833) were retrieved from PubMed and other databases. Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races. Furthermore, ABCA7 loss-of-function (LOF) mutations conferred a higher risk for AD than did the above variants (LOF: OR = 1.78, 95%  = 1.43-2.22). In conclusion, ABCA7 genetic variants, especially the LOF mutations, were significantly associated with the risk of AD.

%B J Alzheimers Dis %V 63 %P 1261-1267 %8 2018 %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/29782324?dopt=Abstract %R 10.3233/JAD-180107