%0 Journal Article %J J Alzheimers Dis %D 2018 %T Efficacy, Acceptability, and Safety of Intravenous Immunoglobulin Administration for Mild-To-Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis. %A Okuya, Makoto %A Matsunaga, Shinji %A Ikuta, Toshikazu %A Kishi, Taro %A Iwata, Nakao %X

A systematic review and meta-analysis of the efficacy/safety of intravenous immunoglobulin (IVIG) administration in mild-to-moderate Alzheimer's disease (AD) patients was performed. Six randomized double-blind, placebo-controlled trials (n = 801) were included in this study. No significant difference in cognitive function was observed between the groups. Moreover, IVIG was inferior to placebo in behavioral disturbances (mean difference = 2.19). Further, IVIG administration was associated with a higher incidence of rash than placebo. Our results do not support IVIG administration for mild-to-moderate AD, suggesting that IVIG is not effective to treat mild-to-moderate AD and that it deteriorates behavioral and psychological symptoms of dementia in mild-to-moderate AD.

%B J Alzheimers Dis %V 66 %P 1379-1387 %8 2018 %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/30452419?dopt=Abstract %R 10.3233/JAD-180888