%0 Journal Article %J J Alzheimers Dis %D 2019 %T Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study. %A Tanprasertsuk, Jirayu %A Johnson, Elizabeth J %A Johnson, Mary Ann %A Poon, Leonard W %A Nelson, Peter T %A Davey, Adam %A Martin, Peter %A Barbey, Aron K %A Barger, Kathryn %A Wang, Xiang-Dong %A Scott, Tammy M %X

BACKGROUND: Centenarian studies are important sources for understanding of factors that contribute to longevity and healthy aging. Clinico-neuropathological finding is a key in identifying pathology and factors contributing to age-related cognitive decline and dementia in the oldest old.

OBJECTIVE: To characterize the cross-sectional relationship between neuropathologies and measures of premortem cognitive performance in centenarians.

METHODS: Data were acquired from 49 centenarians (≥98 years) from the Georgia Centenarian Study. Cognitive assessment from the time point closest to mortality was used (

RESULTS: Wide ranges of AD-type neuropathological changes were observed in both non-demented and demented subjects. Neocortical NFT and Braak staging were related to clinical dementia rating. Neocortical NFT and NP, Braak and NIARI staging, cerebral and ventricular atrophy, HS, CAA, and TDP-43 proteinopathy were differentially associated with poor performance in multiple cognitive domains and activities of daily living.

CONCLUSION: AD-type pathology was associated with severe dementia and poor cognition but was not the only variable that explained cognitive impairment, indicating the complexity and heterogeneity of pathophysiology of dementia in the oldest old.

%B J Alzheimers Dis %V 70 %P 35-49 %8 2019 Jul 2 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/31177211?dopt=Abstract %R 10.3233/JAD-181110