%0 Journal Article %J J Alzheimers Dis %D 2018 %T Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases. %A Babiloni, Claudio %A Del Percio, Claudio %A Lizio, Roberta %A Noce, Giuseppe %A Lopez, Susanna %A Soricelli, Andrea %A Ferri, Raffaele %A Pascarelli, Maria Teresa %A Catania, Valentina %A Nobili, Flavio %A Arnaldi, Dario %A Famá, Francesco %A Aarsland, Dag %A Orzi, Francesco %A Buttinelli, Carla %A Giubilei, Franco %A Onofrj, Marco %A Stocchi, Fabrizio %A Vacca, Laura %A Stirpe, Paola %A Fuhr, Peter %A Gschwandtner, Ute %A Ransmayr, Gerhard %A Garn, Heinrich %A Fraioli, Lucia %A Pievani, Michela %A Frisoni, Giovanni B %A D'Antonio, Fabrizia %A de Lena, Carlo %A Güntekin, Bahar %A Hanoğlu, Lutfu %A Başar, Erol %A Yener, Görsev %A Emek-Savaş, Derya Durusu %A Triggiani, Antonio Ivano %A Franciotti, Raffaella %A Taylor, John Paul %A De Pandis, Maria Francesca %A Bonanni, Laura %X

The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.

%B J Alzheimers Dis %V 62 %P 247-268 %8 2018 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/29439335?dopt=Abstract %R 10.3233/JAD-170703 %0 Journal Article %J J Alzheimers Dis %D 2018 %T Different Abnormalities of Cortical Neural Synchronization Mechanisms in Patients with Mild Cognitive Impairment due to Alzheimer's and Chronic Kidney Diseases: An EEG Study. %A Lizio, Roberta %A Babiloni, Claudio %A Del Percio, Claudio %A Losurdo, Antonia %A Vernò, Lucia %A De Tommaso, Marina %A Montemurno, Anna %A Dalfino, Giuseppe %A Cirillo, Pietro %A Soricelli, Andrea %A Ferri, Raffaele %A Noce, Giuseppe %A Pascarelli, Maria Teresa %A Catania, Valentina %A Nobili, Flavio %A Famá, Francesco %A Orzi, Francesco %A Giubilei, Franco %A Buttinelli, Carla %A Triggiani, A Ivano %A Frisoni, Giovanni B %A Scisci, Anna Maria %A Mastrofilippo, Nicola %A Procaccini, Deni Aldo %A Gesualdo, Loreto %X

This study tested whether resting state alpha rhythms (8-13 Hz) may characterize mild cognitive impairment due to Alzheimer's disease (ADMCI) compared with MCI due to chronic kidney disease (CKDMCI). Clinical and resting state eyes-closed electroencephalographic (rsEEG) rhythms from 40 ADMCI, 29 CKDMCI, and 45 cognitively normal elderly (Nold) subjects were available in a national archive. Age, gender, and education were matched in the three groups, and Mini-Mental State Evaluation (MMSE) score was paired in the ADMCI and CKDMCI groups. Delta (<4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz) cortical sources were estimated by eLORETA freeware and classified across individuals by area under the receiver operating characteristic curve (AUROCC). Compared with Nold group, posterior alpha 1 source activities were more reduced in ADMCI than CKDMCI group. In contrast, widespread delta source activities were greater in CKDMCI than ADMCI group. These source activities correlated with the MMSE score and correctly classified between Nold and all MCI individuals (AUROCC = 0.8-0.85) and between ADMCI and CKDMCI subjects (AUROCC = 0.75). These results suggest that early AD affects cortical neural synchronization at alpha frequencies underpinning brain arousal and low vigilance in the quiet wakefulness. In contrast, CKD may principally affect cortical neural synchronization at the delta frequencies. Future prospective cross-validation studies will have to test these candidate rsEEG markers for clinical applications and drug discovery.

%B J Alzheimers Dis %V 65 %P 897-915 %8 2018 %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/30103322?dopt=Abstract %R 10.3233/JAD-180245 %0 Journal Article %J J Alzheimers Dis %D 2017 %T Abnormalities of Cortical Neural Synchronization Mechanisms in Subjects with Mild Cognitive Impairment due to Alzheimer's and Parkinson's Diseases: An EEG Study. %A Babiloni, Claudio %A Del Percio, Claudio %A Lizio, Roberta %A Noce, Giuseppe %A Cordone, Susanna %A Lopez, Susanna %A Soricelli, Andrea %A Ferri, Raffaele %A Pascarelli, Maria Teresa %A Nobili, Flavio %A Arnaldi, Dario %A Famá, Francesco %A Aarsland, Dag %A Orzi, Francesco %A Buttinelli, Carla %A Giubilei, Franco %A Onofrj, Marco %A Stocchi, Fabrizio %A Stirpe, Paola %A Fuhr, Peter %A Gschwandtner, Ute %A Ransmayr, Gerhard %A Caravias, Georg %A Garn, Heinrich %A Sorpresi, Fabiola %A Pievani, Michela %A D'Antonio, Fabrizia %A de Lena, Carlo %A Güntekin, Bahar %A Hanoğlu, Lutfu %A Başar, Erol %A Yener, Görsev %A Emek-Savaş, Derya Durusu %A Triggiani, Antonio Ivano %A Franciotti, Raffaella %A Frisoni, Giovanni B %A Bonanni, Laura %A De Pandis, Maria Francesca %X

The aim of this retrospective and exploratory study was that the cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and Parkinson's disease (PDMCI) as compared to healthy subjects. Clinical and rsEEG data of 75 ADMCI, 75 PDMCI, and 75 cognitively normal elderly (Nold) subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) was matched between the ADMCI and PDMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROC) classified these sources across individuals. Results showed that compared to the Nold group, the posterior alpha2 and alpha3 source activities were more abnormal in the ADMCI than the PDMCI group, while the parietal delta source activities were more abnormal in the PDMCI than the ADMCI group. The parietal delta and alpha sources correlated with MMSE score and correctly classified the Nold and diseased individuals (area under the ROC = 0.77-0.79). In conclusion, the PDMCI and ADMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test these rsEEG markers for clinical applications and drug discovery.

%B J Alzheimers Dis %V 59 %P 339-358 %8 2017 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/28621693?dopt=Abstract %R 10.3233/JAD-160883