%0 Journal Article %J J Alzheimers Dis %D 2019 %T Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment. %A Oeckl, Patrick %A Halbgebauer, Steffen %A Anderl-Straub, Sarah %A Steinacker, Petra %A Huss, André M %A Neugebauer, Hermann %A von Arnim, Christine A F %A Diehl-Schmid, Janine %A Grimmer, Timo %A Kornhuber, Johannes %A Lewczuk, Piotr %A Danek, Adrian %A Ludolph, Albert C %A Otto, Markus %X

Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p < 0.001) and DLB/PDD (p < 0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p < 0.001). Serum GFAP correlated with the Mini-Mental State Examination score (r= -0.42, p < 0.001) and might be a follow-up marker in clinical trials. Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.

%B J Alzheimers Dis %V 67 %P 481-488 %8 2019 %G eng %N 2 %R 10.3233/JAD-180325