%0 Journal Article %J J Alzheimers Dis %D 2017 %T Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration. %A Toombs, Jamie %A Foiani, Martha S %A Paterson, Ross W %A Heslegrave, Amanda %A Wray, Selina %A Schott, Jonathan M %A Fox, Nick C %A Lunn, Michael P %A Blennow, Kaj %A Zetterberg, Henrik %X

The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-β (Aβ) concentration was investigated. Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube. CSF was analyzed for Aβ38/40/42 using an electrochemiluminescence immunoassay. Relative to control, use of a manometer decreased Aβ38/40/42 concentration by 5.6% (±1.5SE), 4.4% (±1.7SE), and 4.3% (±2.4SE), respectively. The ratios of Aβ42 :40, Aβ42 :38, and Aβ40 :38 were not affected by manometer treatment. Factors which artificially lower CSF Aβ concentrations are relevant to clinical diagnosis for AD and study design.

%B J Alzheimers Dis %V 56 %P 885-891 %8 2017 %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/28059797?dopt=Abstract %R 10.3233/JAD-161126