%0 Journal Article %J J Alzheimers Dis %D 2016 %T Resting-State Cardiac Workload is Related to Both Increased Neocortical Aggregation of Amyloid-β and Relative Impairments in Spatial Working Memory in Pre-Clinical Alzheimer's Disease. %A Santos, Cláudia Yang %A Lim, Yen Ying %A Wu, Wen-Chih %A Machan, Jason Timothy %A Polynice, Shahena %A Schindler, Rachel %A Maruff, Paul %A Snyder, Peter Jeffrey %K Aged %K Alzheimer Disease %K Amyloid beta-Peptides %K Blood Pressure %K Disease Progression %K Female %K Heart Rate %K Humans %K Male %K Maze Learning %K Memory Disorders %K Middle Aged %K Neocortex %K Neuropsychological Tests %K Positron-Emission Tomography %K Protein Aggregation, Pathological %K Workload %X

We sought to determine whether there is any association between a cardiac workload marker, rate pressure product (RPP), working memory, and cortical amyloid-β (Aβ) burden in 63 cognitively normal midlife adults (Mage = 62.8 years; range = 55 to 75 years) at risk for Alzheimer's disease (AD). The results show a small-to-moderate relationship between increasing cardiac workload (at rest) and neocortical amyloidosis in individuals at the preclinical stage of AD. Moreover, increasing RPP was linearly related to increasing relative impairments on a spatial working memory task (R2 = 0.30), but only for those individuals with neuroimaging evidence suggestive of preclinical AD. These results support a relationship between the aggregation of Aβ protein plaques in the neocortex, increased cognitive impairment, and more inefficient myocardial oxygen use in the absence of significant metabolic demands.

%B J Alzheimers Dis %V 50 %P 127-31 %8 2016 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/26639961?dopt=Abstract %R 10.3233/JAD-150576