%0 Journal Article %J J Alzheimers Dis %D 2016 %T Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. %A Hong, Xiao-Ping %A Chen, Tao %A Yin, Ni-Na %A Han, Yong-Ming %A Yuan, Fang %A Duan, Yan-Jun %A Shen, Feng %A Zhang, Yan-Hong %A Chen, Ze-Bin %K Animals %K Cognition Disorders %K Disease Models, Animal %K Fibroblast Growth Factor 2 %K Galactose %K Glycogen Synthase Kinase 3 %K Hippocampus %K Isoflavones %K Male %K Maze Learning %K Neurogenesis %K Neurons %K Neuroprotective Agents %K Phosphorylation %K Random Allocation %K Rats, Sprague-Dawley %K Signal Transduction %K Spatial Memory %K tau Proteins %X

Enhanced neurogenesis has been reported in the hippocampus of patients with Alzheimer's disease (AD), the most common neurodegenerative disorder characterized with amyloid-β (Aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. Previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (GSK-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. In the present study, we found that treatment of D-galactose rats with Puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of D-galactose rat brains. FGF-2/GSK-3 signaling pathway might be involved in the effects of Puerarin on hippocampal neurogenesis and tau hyperphosphorylation. Our finding provides primary in vivo evidence that Puerarin can attenuate AD-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. Our finding also suggests Puerarin can be served as a treatment for age-related neurodegenerative disorders, such as AD.

%B J Alzheimers Dis %V 51 %P 605-17 %8 2016 %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/26890737?dopt=Abstract %R 10.3233/JAD-150566