%0 Journal Article %J J Alzheimers Dis %D 2018 %T Decreased Prefrontal Activation during Matrix Reasoning in Predementia Progranulin Mutation Carriers. %A Alexander, Courtney %A Zeithamova, Dagmar %A Hsiung, Ging-Yuek R %A Mackenzie, Ian R %A Jacova, Claudia %K Adult %K Biomarkers %K Female %K Frontotemporal Dementia %K Functional Neuroimaging %K Heterozygote %K Humans %K Magnetic Resonance Imaging %K Male %K Middle Aged %K Mutation %K Prefrontal Cortex %K Progranulins %X

We tested the potential of task-based functional neuroimaging as a biomarker of emerging prefrontal brain changes in progranulin (GRN) mutations carriers. Five GRN mutation carriers free of frontotemporal dementia (FTD) and 11 non-carriers from families with FTD-GRN underwent functional MRI while solving matrix-reasoning problems. Mutation carriers displayed slower responses for more difficult problems and lower lateral prefrontal activation across all problems. Overall task-evoked posterior ventrolateral prefrontal activation predicted mutation status with 100% sensitivity and 91% specificity. Volumetric differences did not account for activation differences. Prefrontal activation may have utility as a biomarker in GRN mutation.

%B J Alzheimers Dis %V 62 %P 583-589 %8 2018 %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/29480174?dopt=Abstract %R 10.3233/JAD-170716