%0 Journal Article %J J Alzheimers Dis %D 2016 %T Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden. %A Wimo, Anders %A Sjölund, Britt-Marie %A Sköldunger, Anders %A Qiu, Chengxuan %A Klarin, Inga %A Nordberg, Gunilla %A von Strauss, Eva %K Aged %K Aged, 80 and over %K Aging %K Cohort Effect %K Dementia %K Female %K Humans %K Male %K Prevalence %K Risk Factors %K Rural Population %K Sex Factors %K Survival Rate %K Sweden %X

BACKGROUND: Recent studies suggest that trends in cardiovascular risk may result in a decrease in age-specific prevalence of dementia. Studies in rural areas are rare.

OBJECTIVES: To study cohort effects in dementia prevalence and survival of people with dementia in a Swedish rural area.

METHODS: Participants were from the 1995-1998 Nordanstig Project (NP) (n = 303) and the 2001-2003 Swedish National study on Aging and Care in Nordanstig (SNAC-N) (n = 384). Overall 6-year dementia prevalence and mortality in NP and SNAC-N were compared for people 78 years and older. Logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for dementia occurrence using the NP study population as the reference group. Cox regression models were used to analyze time to death.

RESULTS: The crude prevalence of dementia was 21.8% in NP and 17.4% in SNAC-N. When the NP cohort was used as the reference group, the age- and gender-adjusted OR of dementia was 0.71 (95% CI 0.48-1.04) in SNAC-N; the OR was 0.47 (0.24-0.90) for men and 0.88 (0.54-1.44) for women. In the extended model, the OR of dementia was significantly lower in SNAC-N than in the NP cohort as a whole (0.63; 0.39-0.99) and in men (0.34; 0.15-0.79), but not in women (0.81; 0.46-1.44). The Cox regression models indicated that the hazard ratio of dying was lower in the SNAC-N than NP population.

CONCLUSIONS: Trends toward a lower prevalence of dementia in high-income countries seem to be evident in this Swedish rural area, at least in men.

%B J Alzheimers Dis %V 50 %P 387-96 %8 2016 %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/26639970?dopt=Abstract %R 10.3233/JAD-150708