%0 Journal Article %J J Alzheimers Dis %D 2016 %T Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment. %A Balietti, Marta %A Giuli, Cinzia %A Fattoretti, Patrizia %A Fabbietti, Paolo %A Postacchini, Demetrio %A Conti, Fiorenzo %K Blood Platelets %K Cognition %K Cognitive Dysfunction %K Cognitive Therapy %K Cohort Studies %K Humans %K Mental Status Schedule %K Neuropsychological Tests %K Phospholipases A2 %K Treatment Outcome %X

We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA2A.

%B J Alzheimers Dis %V 50 %P 957-62 %8 2016 %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/26836161?dopt=Abstract %R 10.3233/JAD-150714