%0 Journal Article %J J Alzheimers Dis %D 2018 %T Comparison between FCSRT and LASSI-L to Detect Early Stage Alzheimer's Disease. %A Matías-Guiu, Jordi A %A Cabrera-Martín, María Nieves %A Curiel, Rosie E %A Valles-Salgado, María %A Rognoni, Teresa %A Moreno-Ramos, Teresa %A Carreras, José Luis %A Loewenstein, David A %A Matías-Guiu, Jorge %K Aged %K Aged, 80 and over %K Alzheimer Disease %K Cues %K Female %K Fluorodeoxyglucose F18 %K Humans %K Male %K Memory Disorders %K Mental Recall %K Middle Aged %K Neuropsychological Tests %K Positron-Emission Tomography %K Psychiatric Status Rating Scales %K ROC Curve %K Semantics %X

BACKGROUND: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis.

OBJECTIVE: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference.

METHODS: Fifty patients consulting for subjective memory complaints without functional impairment and at risk for AD were enrolled and evaluated using FCSRT, LASSI-L, and FDG-PET. Participants were evaluated using a comprehensive neurological and neuropsychological protocol and were assessed with the FCSRT and LASSI-L. FDG-PET was acquired concomitantly and used for classification of patients as AD or non-AD according to brain metabolism using both visual and semi-quantitative methods.

RESULTS: LASSI-L scores allowed a better classification of patients as AD/non-AD in comparison to FCSRT. Logistic regression analysis showed delayed recall and failure to recovery from proactive semantic interference from LASSI-L as independent statistically significant predictors, obtaining an area under the curve of 0.894. This area under the curve provided a better discrimination than the best FCSRT score (total delayed recall, area under the curve 0.708, p = 0.029).

CONCLUSIONS: The LASSI-L, a cognitive stress test, was superior to FCSRT in the prediction of AD features on FDG-PET. This emphasizes the possibility to advance toward an earlier diagnosis of AD from a clinical perspective.

%B J Alzheimers Dis %V 61 %P 103-111 %8 2018 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/29125488?dopt=Abstract %R 10.3233/JAD-170604