%0 Journal Article %J J Alzheimers Dis %D 2020 %T Cognitive Impairment Is a Common Comorbidity in Deceased COVID-19 Patients: A Hospital-Based Retrospective Cohort Study. %A Martín-Jiménez, Paloma %A Muñoz-García, Mariana I %A Seoane, David %A Roca-Rodríguez, Lucas %A García-Reyne, Ana %A Lalueza, Antonio %A Maestro, Guillermo %A Folgueira, Dolores %A Blanco-Palmero, Víctor A %A Herrero-San Martín, Alejandro %A Llamas-Velasco, Sara %A Pérez-Martínez, David A %A González-Sánchez, Marta %A Villarejo-Galende, Alberto %K Adolescent %K Adult %K Age Factors %K Aged %K Aged, 80 and over %K Cognitive Dysfunction %K Comorbidity %K COVID-19 %K Female %K Hospital Mortality %K Hospitals %K Humans %K Male %K Middle Aged %K Palliative Care %K Patient Admission %K Retrospective Studies %K Spain %K Young Adult %X

We analyzed the frequency of cognitive impairment (CI) in deceased COVID-19 patients at a tertiary hospital in Spain. Among the 477 adult cases who died after admission from March 1 to March 31, 2020, 281 had confirmed COVID-19. CI (21.1% dementia and 8.9% mild cognitive impairment) was a common comorbidity. Subjects with CI were older, tended to live in nursing homes, had shorter time from symptom onset to death, and were rarely admitted to the ICU, receiving palliative care more often. CI is a frequent comorbidity in deceased COVID-19 subjects and is associated with differences in care.

%B J Alzheimers Dis %V 78 %P 1367-1372 %8 2020 %G eng %N 4 %1 https://www.ncbi.nlm.nih.gov/pubmed/33074239?dopt=Abstract %R 10.3233/JAD-200937 %0 Journal Article %J J Alzheimers Dis %D 2018 %T SORL1 Variants in Familial Alzheimer's Disease. %A Gómez-Tortosa, Estrella %A Ruggiero, María %A Sainz, Ma José %A Villarejo-Galende, Alberto %A Prieto-Jurczynska, Cristina %A Venegas Pérez, Begoña %A Ordás, Carlos %A Agüero, Pablo %A Guerrero-López, Rosa %A Pérez-Pérez, Julián %K Aged %K Alzheimer Disease %K Case-Control Studies %K Female %K Gene Frequency %K Genetic Predisposition to Disease %K Humans %K LDL-Receptor Related Proteins %K Male %K Membrane Transport Proteins %K Middle Aged %K Mutation %K Polymorphism, Single Nucleotide %K Siblings %K Spain %X

The SORL1 gene encodes a protein involved in the amyloidogenic process, and its variants have been associated with Alzheimer's disease (AD) physiopathology. We screened for SORL1 variants in 124 familial (44 early- and 80 late-onset) dementia of Alzheimer type (DAT) cases. Nine potentially pathogenic changes (three not previously reported and six rare variants) were found in nine probands (7%). After screening the control population and siblings (presence in at least 1/200 controls and/or absence of segregation pattern), a causal relationship with the disease was considered unlikely in six variants and uncertain in one. The change Trp848Ter and a splice-site variant remained likely correlated with the disease. SORL1 mutations are present in 7% of our familial DAT cohort, though in most cases cannot be considered the direct cause of the disease.

%B J Alzheimers Dis %V 61 %P 1275-1281 %8 2018 %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/29376855?dopt=Abstract %R 10.3233/JAD-170590