tau Proteins
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Survival Analysis
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Retrospective Studies
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
Predictive Value of Tests
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
Positron-Emission Tomography
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Polymorphism, Single Nucleotide
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J.,
“Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”,
PLoS One, vol. 5, no. 11, p. e13950, 2010.
Phenotype
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
Peptide Fragments
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
Neuropsychological Tests
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Middle Aged
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Mental Status Schedule
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
Male
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
S. J. Teipel, Dyrba, M., Ballarini, T., Brosseron, F., Bruno, D., Buerger, K., Cosma, N. - C., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Haynes, J. D., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C. D., Munk, M. H., Peters, O., Pomara, N., Preis, L., Priller, J., Rámirez, A., Roy, N., Scheffler, K., Schneider, A., Schott, B. H., Spottke, A., Spruth, E. J., Wagner, M., Wiltfang, J., Jessen, F., and Heneka, M. T.,
“Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum.”,
J Alzheimers Dis, vol. 85, no. 3, pp. 1267-1282, 2022.
Magnetic Resonance Imaging
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
S. J. Teipel, Dyrba, M., Ballarini, T., Brosseron, F., Bruno, D., Buerger, K., Cosma, N. - C., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Haynes, J. D., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C. D., Munk, M. H., Peters, O., Pomara, N., Preis, L., Priller, J., Rámirez, A., Roy, N., Scheffler, K., Schneider, A., Schott, B. H., Spottke, A., Spruth, E. J., Wagner, M., Wiltfang, J., Jessen, F., and Heneka, M. T.,
“Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum.”,
J Alzheimers Dis, vol. 85, no. 3, pp. 1267-1282, 2022.
Longitudinal Studies
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Logistic Models
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M.,
“The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.”,
J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
Inflammation
S. J. Teipel, Dyrba, M., Ballarini, T., Brosseron, F., Bruno, D., Buerger, K., Cosma, N. - C., Dechent, P., Dobisch, L., Düzel, E., Ewers, M., Fliessbach, K., Haynes, J. D., Janowitz, D., Kilimann, I., Laske, C., Maier, F., Metzger, C. D., Munk, M. H., Peters, O., Pomara, N., Preis, L., Priller, J., Rámirez, A., Roy, N., Scheffler, K., Schneider, A., Schott, B. H., Spottke, A., Spruth, E. J., Wagner, M., Wiltfang, J., Jessen, F., and Heneka, M. T.,
“Association of Cholinergic Basal Forebrain Volume and Functional Connectivity with Markers of Inflammatory Response in the Alzheimer's Disease Spectrum.”,
J Alzheimers Dis, vol. 85, no. 3, pp. 1267-1282, 2022.
Immune System
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J.,
“Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”,
PLoS One, vol. 5, no. 11, p. e13950, 2010.
Imaging, Three-Dimensional
C. Lange, Suppa, P., Pietrzyk, U., Makowski, M. R., Spies, L., Peters, O., and Buchert, R.,
“Prediction of Alzheimer's Dementia in Patients with Amnestic Mild Cognitive Impairment in Clinical Routine: Incremental Value of Biomarkers of Neurodegeneration and Brain Amyloidosis Added Stepwise to Cognitive Status.”,
J Alzheimers Dis, vol. 61, no. 1, pp. 373-388, 2018.
Pages
