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Animals
K. R. LeVault, Tischkau, S. A., and Brewer, G. J., Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer's Disease Mouse Model., J Alzheimers Dis, vol. 49, no. 2, pp. 301-16, 2016.
P. Banerjee, Sahoo, A., Anand, S., Bir, A., and Chakrabarti, S., The Oral Iron Chelator, Deferasirox, Reverses the Age-Dependent Alterations in Iron and Amyloid-β Homeostasis in Rat Brain: Implications in the Therapy of Alzheimer's Disease., J Alzheimers Dis, vol. 49, no. 3, pp. 681-93, 2016.
A. de Calignon, Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., Spires-Jones, T. L., and Hyman, B. T., Propagation of tau pathology in a model of early Alzheimer's disease., Neuron, vol. 73, no. 4, pp. 685-97, 2012.
R. Guerreiro, Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., Hazrati, L., Collinge, J., Pocock, J., Lashley, T., Williams, J., Lambert, J. - C., Amouyel, P., Goate, A., Rademakers, R., Morgan, K., Powell, J., St George-Hyslop, P., Singleton, A., and Hardy, J., TREM2 variants in Alzheimer's disease., N Engl J Med, vol. 368, no. 2, pp. 117-27, 2013.
M. Jin, Shepardson, N., Yang, T., Chen, G., Walsh, D., and Selkoe, D. J., Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration., Proc Natl Acad Sci U S A, vol. 108, no. 14, pp. 5819-24, 2011.
D. A. Gimbel, Nygaard, H. B., Coffey, E. E., Gunther, E. C., Laurén, J., Gimbel, Z. A., and Strittmatter, S. M., Memory impairment in transgenic Alzheimer mice requires cellular prion protein., J Neurosci, vol. 30, no. 18, pp. 6367-74, 2010.
Y. Stern, Cognitive reserve in ageing and Alzheimer's disease., Lancet Neurol, vol. 11, no. 11, pp. 1006-12, 2012.
M. Jucker and Walker, L. C., Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders., Ann Neurol, vol. 70, no. 4, pp. 532-40, 2011.
G. He, Luo, W., Li, P., Remmers, C., Netzer, W. J., Hendrick, J., Bettayeb, K., Flajolet, M., Gorelick, F., Wennogle, L. P., and Greengard, P., Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease., Nature, vol. 467, no. 7311, pp. 95-8, 2010.
E. G. McGeer and McGeer, P. L., Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy., J Alzheimers Dis, vol. 19, no. 1, pp. 355-61, 2010.
D. Kapogiannis and Mattson, M. P., Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease., Lancet Neurol, vol. 10, no. 2, pp. 187-98, 2011.
J. A. Miller, Horvath, S., and Geschwind, D. H., Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways., Proc Natl Acad Sci U S A, vol. 107, no. 28, pp. 12698-703, 2010.
K. Iqbal, Liu, F., Gong, C. - X., and Grundke-Iqbal, I., Tau in Alzheimer disease and related tauopathies., Curr Alzheimer Res, vol. 7, no. 8, pp. 656-64, 2010.
A. Griciuc, Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. Hoon, Hyman, B. T., and Tanzi, R. E., Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta., Neuron, vol. 78, no. 4, pp. 631-43, 2013.
M. Bolós, Llorens-Martín, M., Jurado-Arjona, J., Hernández, F., Rábano, A., and Avila, J., Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo., J Alzheimers Dis, vol. 50, no. 1, pp. 77-87, 2016.
C. Deochand, Tong, M., Agarwal, A. R., Cadenas, E., and de la Monte, S. M., Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration., J Alzheimers Dis, vol. 50, no. 2, pp. 373-86, 2016.
A. Ezra, Rabinovich-Nikitin, I., Rabinovich-Toidman, P., and Solomon, B., Multifunctional Effect of Human Serum Albumin Reduces Alzheimer's Disease Related Pathologies in the 3xTg Mouse Model., J Alzheimers Dis, vol. 50, no. 1, pp. 175-88, 2016.
S. A. Villeda, Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., Wabl, R., Udeochu, J., Wheatley, E. G., Zou, B., Simmons, D. A., Xie, X. S., Longo, F. M., and Wyss-Coray, T., Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice., Nat Med, vol. 20, no. 6, pp. 659-63, 2014.
T. Lu, Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T. - H., Kim, H. - M., Drake, D., X Liu, S., Bennett, D. A., Colaiácovo, M. P., and Yankner, B. A., REST and stress resistance in ageing and Alzheimer's disease., Nature, vol. 507, no. 7493, pp. 448-54, 2014.
B. Zhang, Gaiteri, C., Bodea, L. - G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., Fluder, E., Clurman, B., Melquist, S., Narayanan, M., Suver, C., Shah, H., Mahajan, M., Gillis, T., Mysore, J., MacDonald, M. E., Lamb, J. R., Bennett, D. A., Molony, C., Stone, D. J., Gudnason, V., Myers, A. J., Schadt, E. E., Neumann, H., Zhu, J., and Emilsson, V., Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease., Cell, vol. 153, no. 3, pp. 707-20, 2013.
J. J. Iliff, Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., G Vates, E., Deane, R., Goldman, S. A., Nagelhus, E. A., and Nedergaard, M., A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β., Sci Transl Med, vol. 4, no. 147, p. 147ra111, 2012.
J. Gräff, Rei, D., Guan, J. - S., Wang, W. - Y., Seo, J., Hennig, K. M., Nieland, T. J. F., Fass, D. M., Kao, P. F., Kahn, M., Su, S. C., Samiei, A., Joseph, N., Haggarty, S. J., Delalle, I., and Tsai, L. - H., An epigenetic blockade of cognitive functions in the neurodegenerating brain., Nature, vol. 483, no. 7388, pp. 222-6, 2012.
M. Wang, Gamo, N. J., Yang, Y., Jin, L. E., Wang, X. - J., Laubach, M., Mazer, J. A., Lee, D., and Arnsten, A. F. T., Neuronal basis of age-related working memory decline., Nature, vol. 476, no. 7359, pp. 210-3, 2011.
J. M. Castellano, Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., Goate, A. M., Bales, K. R., Paul, S. M., Bateman, R. J., and Holtzman, D. M., Human apoE isoforms differentially regulate brain amyloid-β peptide clearance., Sci Transl Med, vol. 3, no. 89, p. 89ra57, 2011.
A. W. Bero, Yan, P., Roh, J. Hoon, Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J. - M., and Holtzman, D. M., Neuronal activity regulates the regional vulnerability to amyloid-β deposition., Nat Neurosci, vol. 14, no. 6, pp. 750-6, 2011.

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