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Humans
M. Edwards, Hall, J., Williams, B., Johnson, L., and O'Bryant, S., Molecular markers of amnestic mild cognitive impairment among Mexican Americans., J Alzheimers Dis, vol. 49, no. 1, pp. 221-8, 2016.
K. R. LeVault, Tischkau, S. A., and Brewer, G. J., Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer's Disease Mouse Model., J Alzheimers Dis, vol. 49, no. 2, pp. 301-16, 2016.
N. Voyle, Keohane, A., Newhouse, S., Lunnon, K., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A., Kiddle, S., and Dobson, R. Jb, A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis., J Alzheimers Dis, vol. 49, no. 3, pp. 659-69, 2016.
A. Koppara, Wolfsgruber, S., Kleineidam, L., Schmidtke, K., Frölich, L., Kurz, A., Schulz, S., Hampel, H., Heuser, I., Peters, O., Reischies, F. M., Jahn, H., Luckhaus, C., Hüll, M., Gertz, H. - J., Schröder, J., Pantel, J., Rienhoff, O., Rüther, E., Henn, F., Wiltfang, J., Maier, W., Jessen, F., Kornhuber, J., and Wagner, M., The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment., J Alzheimers Dis, vol. 49, no. 2, pp. 547-60, 2016.
C. R. Jack, Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., Lesnick, T. G., Pankratz, V. S., Donohue, M. C., and Trojanowski, J. Q., Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers., Lancet Neurol, vol. 12, no. 2, pp. 207-16, 2013.
A. de Calignon, Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., Spires-Jones, T. L., and Hyman, B. T., Propagation of tau pathology in a model of early Alzheimer's disease., Neuron, vol. 73, no. 4, pp. 685-97, 2012.
R. Guerreiro, Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., Hazrati, L., Collinge, J., Pocock, J., Lashley, T., Williams, J., Lambert, J. - C., Amouyel, P., Goate, A., Rademakers, R., Morgan, K., Powell, J., St George-Hyslop, P., Singleton, A., and Hardy, J., TREM2 variants in Alzheimer's disease., N Engl J Med, vol. 368, no. 2, pp. 117-27, 2013.
J. C. Morris, Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., and Mintun, M. A., APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging., Ann Neurol, vol. 67, no. 1, pp. 122-31, 2010.
M. Jin, Shepardson, N., Yang, T., Chen, G., Walsh, D., and Selkoe, D. J., Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration., Proc Natl Acad Sci U S A, vol. 108, no. 14, pp. 5819-24, 2011.
J. C. Lambert, Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., DeStafano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thorton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, M. T., Choi, S. H., Reitz, C., Pasquier, F., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Morón, F. J., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiévet, N., Huentelman, M. W., Gill, M., Brown, K., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuiness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N. C., Hardy, J., Naranjo, M. C. Deniz, Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Mayhaus, M., Lannefelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Holmes, C., de Bruijn, R. F., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltuenen, M., Martin, E. R., Schmidt, R., Rujescu, D., Wang, L. S., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Psaty, B. M., Jones, L., Haines, J. L., Holmans, P. A., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Farrer, L. A., van Duijn, C. M., Van Broeckhoven, C., Moskvina, V., Seshadri, S., Williams, J., Schellenberg, G. D., and Amouyel, P., Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease., Nat Genet, vol. 45, no. 12, pp. 1452-8, 2013.
R. C. Petersen, Aisen, P. S., Beckett, L. A., Donohue, M. C., Gamst, A. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Shaw, L. M., Toga, A. W., Trojanowski, J. Q., and Weiner, M. W., Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization., Neurology, vol. 74, no. 3, pp. 201-9, 2010.
Y. Stern, Cognitive reserve in ageing and Alzheimer's disease., Lancet Neurol, vol. 11, no. 11, pp. 1006-12, 2012.
M. Jucker and Walker, L. C., Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders., Ann Neurol, vol. 70, no. 4, pp. 532-40, 2011.
L. Qiang, Fujita, R., Yamashita, T., Angulo, S., Rhinn, H., Rhee, D., Doege, C., Chau, L., Aubry, L., Vanti, W. B., Moreno, H., and Abeliovich, A., Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons., Cell, vol. 146, no. 3, pp. 359-71, 2011.
T. E. Golde, Schneider, L. S., and Koo, E. H., Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift., Neuron, vol. 69, no. 2, pp. 203-13, 2011.
C. R. Jack, Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., Roberts, R. O., Rocca, W. A., Boeve, B. F., and Petersen, R. C., An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease., Ann Neurol, vol. 71, no. 6, pp. 765-75, 2012.
G. He, Luo, W., Li, P., Remmers, C., Netzer, W. J., Hendrick, J., Bettayeb, K., Flajolet, M., Gorelick, F., Wennogle, L. P., and Greengard, P., Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease., Nature, vol. 467, no. 7311, pp. 95-8, 2010.
E. G. McGeer and McGeer, P. L., Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy., J Alzheimers Dis, vol. 19, no. 1, pp. 355-61, 2010.
D. Kapogiannis and Mattson, M. P., Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease., Lancet Neurol, vol. 10, no. 2, pp. 187-98, 2011.
J. A. Miller, Horvath, S., and Geschwind, D. H., Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways., Proc Natl Acad Sci U S A, vol. 107, no. 28, pp. 12698-703, 2010.
M. L. Daviglus, Bell, C. C., Berrettini, W., Bowen, P. E., E Connolly, S., Cox, N. Jean, Dunbar-Jacob, J. M., Granieri, E. C., Hunt, G., McGarry, K., Patel, D., Potosky, A. L., Sanders-Bush, E., Silberberg, D., and Trevisan, M., National Institutes of Health State-of-the-Science Conference statement: preventing alzheimer disease and cognitive decline., Ann Intern Med, vol. 153, no. 3, pp. 176-81, 2010.
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J., Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease., PLoS One, vol. 5, no. 11, p. e13950, 2010.
K. Iqbal, Liu, F., Gong, C. - X., and Grundke-Iqbal, I., Tau in Alzheimer disease and related tauopathies., Curr Alzheimer Res, vol. 7, no. 8, pp. 656-64, 2010.
T. Kondo, Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O., Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S. - I., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., and Inoue, H., Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness., Cell Stem Cell, vol. 12, no. 4, pp. 487-96, 2013.
J. Li, Wang, Y. J., Zhang, M., Xu, Z. Q., Gao, C. Y., Fang, C. Q., Yan, J. C., and Zhou, H. D., Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease., Neurology, vol. 76, no. 17, pp. 1485-91, 2011.

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