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Alzheimer Disease
J. Li, Wang, Y. J., Zhang, M., Xu, Z. Q., Gao, C. Y., Fang, C. Q., Yan, J. C., and Zhou, H. D., Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease., Neurology, vol. 76, no. 17, pp. 1485-91, 2011.
A. Griciuc, Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. Hoon, Hyman, B. T., and Tanzi, R. E., Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta., Neuron, vol. 78, no. 4, pp. 631-43, 2013.
M. Sattlecker, Khondoker, M., Proitsi, P., Williams, S., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., and Dobson, R. Jb, Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease., J Alzheimers Dis, vol. 49, no. 4, pp. 1105-14, 2016.
M. Bolós, Llorens-Martín, M., Jurado-Arjona, J., Hernández, F., Rábano, A., and Avila, J., Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo., J Alzheimers Dis, vol. 50, no. 1, pp. 77-87, 2016.
K. Hoffmann, Sobol, N. A., Frederiksen, K. S., Beyer, N., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jacobsen, S., Laugesen, L. P., Gergelyffy, R. G., Høgh, P., Bjerregaard, E., Andersen, B. B., Siersma, V., Johannsen, P., Cotman, C. W., Waldemar, G., and Hasselbalch, S. G., Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial., J Alzheimers Dis, vol. 50, no. 2, pp. 443-53, 2016.
A. Hatami, Monjazeb, S., and Glabe, C., The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils., J Alzheimers Dis, vol. 50, no. 2, pp. 517-25, 2016.
K. Steenland, Goldstein, F. C., Levey, A., and Wharton, W., A Meta-Analysis of Alzheimer's Disease Incidence and Prevalence Comparing African-Americans and Caucasians., J Alzheimers Dis, vol. 50, no. 1, pp. 71-6, 2016.
A. Ezra, Rabinovich-Nikitin, I., Rabinovich-Toidman, P., and Solomon, B., Multifunctional Effect of Human Serum Albumin Reduces Alzheimer's Disease Related Pathologies in the 3xTg Mouse Model., J Alzheimers Dis, vol. 50, no. 1, pp. 175-88, 2016.
H. Hochstetler, Trzepacz, P. T., Wang, S., Yu, P., Case, M., Henley, D. B., Degenhardt, E., Leoutsakos, J. - M., and Lyketsos, C. G., Empirically Defining Trajectories of Late-Life Cognitive and Functional Decline., J Alzheimers Dis, vol. 50, no. 1, pp. 271-82, 2016.
C. E. Fischer, Qian, W., Schweizer, T. A., Millikin, C. P., Ismail, Z., Smith, E. E., Lix, L. M., Shelton, P., and Munoz, D. G., Lewy Bodies, Vascular Risk Factors, and Subcortical Arteriosclerotic Leukoencephalopathy, but not Alzheimer Pathology, are Associated with Development of Psychosis in Alzheimer's Disease., J Alzheimers Dis, vol. 50, no. 1, pp. 283-95, 2016.
S. Hoon Choi, Kim, Y. Hye, Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., and Kim, D. Yeon, A three-dimensional human neural cell culture model of Alzheimer's disease., Nature, vol. 515, no. 7526, pp. 274-8, 2014.
B. Dubois, Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. Luis, Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., Cappa, S., Crutch, S., Engelborghs, S., Frisoni, G. B., Fox, N. C., Galasko, D., Habert, M. - O., Jicha, G. A., Nordberg, A., Pasquier, F., Rabinovici, G., Robert, P., Rowe, C., Salloway, S., Sarazin, M., Epelbaum, S., de Souza, L. C., Vellas, B., Visser, P. J., Schneider, L., Stern, Y., Scheltens, P., and Cummings, J. L., Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria., Lancet Neurol, vol. 13, no. 6, pp. 614-29, 2014.
T. Lu, Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T. - H., Kim, H. - M., Drake, D., X Liu, S., Bennett, D. A., Colaiácovo, M. P., and Yankner, B. A., REST and stress resistance in ageing and Alzheimer's disease., Nature, vol. 507, no. 7493, pp. 448-54, 2014.
M. Mapstone, Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., Nazar, M. D., Rich, S. A., Berlau, D. J., Peltz, C. B., Tan, M. T., Kawas, C. H., and Federoff, H. J., Plasma phospholipids identify antecedent memory impairment in older adults., Nat Med, vol. 20, no. 4, pp. 415-8, 2014.
S. Salloway, Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., Reichert, M., Ketter, N., Nejadnik, B., Guenzler, V., Miloslavsky, M., Wang, D., Lu, Y., Lull, J., Tudor, I. Cristina, Liu, E., Grundman, M., Yuen, E., Black, R., and H Brashear, R., Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease., N Engl J Med, vol. 370, no. 4, pp. 322-33, 2014.
R. S. Doody, Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., Siemers, E., Liu-Seifert, H., and Mohs, R., Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease., N Engl J Med, vol. 370, no. 4, pp. 311-21, 2014.
B. Zhang, Gaiteri, C., Bodea, L. - G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., Fluder, E., Clurman, B., Melquist, S., Narayanan, M., Suver, C., Shah, H., Mahajan, M., Gillis, T., Mysore, J., MacDonald, M. E., Lamb, J. R., Bennett, D. A., Molony, C., Stone, D. J., Gudnason, V., Myers, A. J., Schadt, E. E., Neumann, H., Zhu, J., and Emilsson, V., Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease., Cell, vol. 153, no. 3, pp. 707-20, 2013.
T. Jonsson, Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., Hoyte, K., Gustafson, A., Liu, Y., Lu, Y., Bhangale, T., Graham, R. R., Huttenlocher, J., Bjornsdottir, G., Andreassen, O. A., Jönsson, E. G., Palotie, A., Behrens, T. W., Magnusson, O. T., Kong, A., Thorsteinsdottir, U., Watts, R. J., and Stefansson, K., A mutation in APP protects against Alzheimer's disease and age-related cognitive decline., Nature, vol. 488, no. 7409, pp. 96-9, 2012.
K. Talbot, Wang, H. - Y., Kazi, H., Han, L. - Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., Arvanitakis, Z., Schneider, J. A., Wolf, B. A., Bennett, D. A., Trojanowski, J. Q., and Arnold, S. E., Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline., J Clin Invest, vol. 122, no. 4, pp. 1316-38, 2012.
J. Gräff, Rei, D., Guan, J. - S., Wang, W. - Y., Seo, J., Hennig, K. M., Nieland, T. J. F., Fass, D. M., Kao, P. F., Kahn, M., Su, S. C., Samiei, A., Joseph, N., Haggarty, S. J., Delalle, I., and Tsai, L. - H., An epigenetic blockade of cognitive functions in the neurodegenerating brain., Nature, vol. 483, no. 7388, pp. 222-6, 2012.
B. T. Hyman, Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., Nelson, P. T., Schneider, J. A., Thal, D. Rudolf, Thies, B., Trojanowski, J. Q., Vinters, H. V., and Montine, T. J., National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease., Alzheimers Dement, vol. 8, no. 1, pp. 1-13, 2012.
P. Buchhave, Minthon, L., Zetterberg, H., Wallin, A. K., Blennow, K., and Hansson, O., Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia., Arch Gen Psychiatry, vol. 69, no. 1, pp. 98-106, 2012.
H. Braak, Thal, D. R., Ghebremedhin, E., and Del Tredici, K., Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years., J Neuropathol Exp Neurol, vol. 70, no. 11, pp. 960-9, 2011.
C. R. Jack, Vemuri, P., Wiste, H. J., Weigand, S. D., Aisen, P. S., Trojanowski, J. Q., Shaw, L. M., Bernstein, M. A., Petersen, R. C., Weiner, M. W., and Knopman, D. S., Evidence for ordering of Alzheimer disease biomarkers., Arch Neurol, vol. 68, no. 12, pp. 1526-35, 2011.
J. M. Castellano, Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., Goate, A. M., Bales, K. R., Paul, S. M., Bateman, R. J., and Holtzman, D. M., Human apoE isoforms differentially regulate brain amyloid-β peptide clearance., Sci Transl Med, vol. 3, no. 89, p. 89ra57, 2011.

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