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Aged, 80 and over
S. M. Vasunilashorn, Fong, T. G., Albuquerque, A., Marcantonio, E. R., Schmitt, E. M., Tommet, D., Gou, Y., Travison, T. G., Jones, R. N., and Inouye, S. K., “Delirium Severity Post-Surgery and its Relationship with Long-Term Cognitive Decline in a Cohort of Patients without Dementia.”, J Alzheimers Dis, vol. 61, no. 1, pp. 347-358, 2018.
N. Kuriyama, Ozaki, E., Mizuno, T., Ihara, M., Mizuno, S., Koyama, T., Matsui, D., Watanabe, I., Akazawa, K., Takeda, K., Takada, A., Inaba, M., Yamada, S., Motoyama, K., Takeshita, W., Iwai, K., Hashiguchi, K., Kobayashi, D., Kondo, M., Tamura, A., Yamada, K., Nakagawa, M., and Watanabe, Y., “Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.”, J Alzheimers Dis, vol. 61, no. 1, pp. 145-155, 2018.
N. Kuriyama, Ozaki, E., Mizuno, T., Ihara, M., Mizuno, S., Koyama, T., Matsui, D., Watanabe, I., Akazawa, K., Takeda, K., Takada, A., Inaba, M., Yamada, S., Motoyama, K., Takeshita, W., Iwai, K., Hashiguchi, K., Kobayashi, D., Kondo, M., Tamura, A., Yamada, K., Nakagawa, M., and Watanabe, Y., “Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.”, J Alzheimers Dis, vol. 61, no. 1, pp. 145-155, 2018.
N. Kuriyama, Ozaki, E., Mizuno, T., Ihara, M., Mizuno, S., Koyama, T., Matsui, D., Watanabe, I., Akazawa, K., Takeda, K., Takada, A., Inaba, M., Yamada, S., Motoyama, K., Takeshita, W., Iwai, K., Hashiguchi, K., Kobayashi, D., Kondo, M., Tamura, A., Yamada, K., Nakagawa, M., and Watanabe, Y., “Association between α-Klotho and Deep White Matter Lesions in the Brain: A Pilot Case Control Study Using Brain MRI.”, J Alzheimers Dis, vol. 61, no. 1, pp. 145-155, 2018.
A. Dodich, Cerami, C., Cappa, S. F., Marcone, A., Golzi, V., Zamboni, M., Giusti, M. Cristina, and Iannaccone, S., “Combined Socio-Behavioral Evaluation Improves the Differential Diagnosis Between the Behavioral Variant of Frontotemporal Dementia and Alzheimer's Disease: In Search of Neuropsychological Markers.”, J Alzheimers Dis, vol. 61, no. 2, pp. 761-772, 2018.
A. Kimura, Yoshikura, N., Hayashi, Y., and Inuzuka, T., “Cerebrospinal Fluid C-C Motif Chemokine Ligand 2 Correlates with Brain Atrophy and Cognitive Impairment in Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 2, pp. 581-588, 2018.
T. G. Beach, Maarouf, C. L., Intorcia, A., Sue, L. I., Serrano, G. E., Lu, M., Joshi, A., Pontecorvo, M. J., and Roher, A. E., “Antemortem-Postmortem Correlation of Florbetapir (18F) PET Amyloid Imaging with Quantitative Biochemical Measures of Aβ42 but not Aβ40.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1509-1516, 2018.
M. Ishikawa, Yamada, S., and Yamamoto, K., “Dilated Perivascular Spaces in the Centrum Semiovale Begin to Develop in Middle Age.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1619-1626, 2018.
J. L. Del-Aguila, Fernández, M. Victoria, Schindler, S., Ibanez, L., Deming, Y., Ma, S., Saef, B., Black, K., Budde, J., Norton, J., Chasse, R., Harari, O., Goate, A., Xiong, C., Morris, J. C., and Cruchaga, C., “Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.”, J Alzheimers Dis, vol. 62, no. 2, pp. 745-756, 2018.
Z. Ismail, McGirr, A., Gill, S., Hu, S., Forkert, N. D., and Smith, E. E., “Mild Behavioral Impairment and Subjective Cognitive Decline Predict Cognitive and Functional Decline.”, J Alzheimers Dis, vol. 80, no. 1, pp. 459-469, 2021.
S. Ikeda, Mimura, M., Ikeda, M., Wada-Isoe, K., Azuma, M., Inoue, S., and Tomita, K., “Economic Burden of Alzheimer's Disease Dementia in Japan.”, J Alzheimers Dis, vol. 81, no. 1, pp. 309-319, 2021.
S. Ikeda, Mimura, M., Ikeda, M., Wada-Isoe, K., Azuma, M., Inoue, S., and Tomita, K., “Economic Burden of Alzheimer's Disease Dementia in Japan.”, J Alzheimers Dis, vol. 81, no. 1, pp. 309-319, 2021.
S. Ikeda, Mimura, M., Ikeda, M., Wada-Isoe, K., Azuma, M., Inoue, S., and Tomita, K., “Economic Burden of Alzheimer's Disease Dementia in Japan.”, J Alzheimers Dis, vol. 81, no. 1, pp. 309-319, 2021.
D. Asaoka, Xiao, J., Takeda, T., Yanagisawa, N., Yamazaki, T., Matsubara, Y., Sugiyama, H., Endo, N., Higa, M., Kasanuki, K., Ichimiya, Y., Koido, S., Ohno, K., Bernier, F., Katsumata, N., Nagahara, A., Arai, H., Ohkusa, T., and Sato, N., “Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial.”, J Alzheimers Dis, vol. 88, no. 1, pp. 75-95, 2022.
Aging
T. Hisatsune, Kaneko, J., Kurashige, H., Cao, Y., Satsu, H., Totsuka, M., Katakura, Y., Imabayashi, E., and Matsuda, H., “Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People.”, J Alzheimers Dis, vol. 50, no. 1, pp. 149-59, 2016.
Y. Hasegawa, Toyama, K., Uekawa, K., Ichijo, H., and Kim-Mitsuyama, S., “Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging.”, J Alzheimers Dis, vol. 61, no. 1, pp. 259-263, 2018.
M. Ishikawa, Yamada, S., and Yamamoto, K., “Dilated Perivascular Spaces in the Centrum Semiovale Begin to Develop in Middle Age.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1619-1626, 2018.
M. Vassilaki, Crowson, C. S., Iii, J. M. Davis, Duong, S. Q., Jones, D. T., Nguyen, A., Mielke, M. M., Vemuri, P., and Myasoedova, E., “Rheumatoid Arthritis, Cognitive Impairment, and Neuroimaging Biomarkers: Results from the Mayo Clinic Study of Aging.”, J Alzheimers Dis, vol. 89, no. 3, pp. 943-954, 2022.
alpha7 Nicotinic Acetylcholine Receptor
K. Nakaizumi, Ouchi, Y., Terada, T., Yoshikawa, E., Kakimoto, A., Isobe, T., Bunai, T., Yokokura, M., Suzuki, K., and Magata, Y., “In vivo Depiction of α7 Nicotinic Receptor Loss for Cognitive Decline in Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1355-1365, 2018.
Alzheimer Disease
J. C. Lambert, Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., DeStafano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thorton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, M. T., Choi, S. H., Reitz, C., Pasquier, F., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Morón, F. J., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiévet, N., Huentelman, M. W., Gill, M., Brown, K., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuiness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N. C., Hardy, J., Naranjo, M. C. Deniz, Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Mayhaus, M., Lannefelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Holmes, C., de Bruijn, R. F., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltuenen, M., Martin, E. R., Schmidt, R., Rujescu, D., Wang, L. S., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Psaty, B. M., Jones, L., Haines, J. L., Holmans, P. A., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Farrer, L. A., van Duijn, C. M., Van Broeckhoven, C., Moskvina, V., Seshadri, S., Williams, J., Schellenberg, G. D., and Amouyel, P., “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.”, Nat Genet, vol. 45, no. 12, pp. 1452-8, 2013.
J. C. Lambert, Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., DeStafano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thorton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, M. T., Choi, S. H., Reitz, C., Pasquier, F., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Morón, F. J., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiévet, N., Huentelman, M. W., Gill, M., Brown, K., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuiness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N. C., Hardy, J., Naranjo, M. C. Deniz, Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Mayhaus, M., Lannefelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Holmes, C., de Bruijn, R. F., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltuenen, M., Martin, E. R., Schmidt, R., Rujescu, D., Wang, L. S., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Psaty, B. M., Jones, L., Haines, J. L., Holmans, P. A., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Farrer, L. A., van Duijn, C. M., Van Broeckhoven, C., Moskvina, V., Seshadri, S., Williams, J., Schellenberg, G. D., and Amouyel, P., “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.”, Nat Genet, vol. 45, no. 12, pp. 1452-8, 2013.
J. C. Lambert, Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., DeStafano, A. L., Bis, J. C., Beecham, G. W., Grenier-Boley, B., Russo, G., Thorton-Wells, T. A., Jones, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C. F., Gerrish, A., Schmidt, H., Kunkle, B., Dunstan, M. L., Ruiz, A., Bihoreau, M. T., Choi, S. H., Reitz, C., Pasquier, F., Cruchaga, C., Craig, D., Amin, N., Berr, C., Lopez, O. L., De Jager, P. L., Deramecourt, V., Johnston, J. A., Evans, D., Lovestone, S., Letenneur, L., Morón, F. J., Rubinsztein, D. C., Eiriksdottir, G., Sleegers, K., Goate, A. M., Fiévet, N., Huentelman, M. W., Gill, M., Brown, K., Kamboh, M. I., Keller, L., Barberger-Gateau, P., McGuiness, B., Larson, E. B., Green, R., Myers, A. J., Dufouil, C., Todd, S., Wallon, D., Love, S., Rogaeva, E., Gallacher, J., St George-Hyslop, P., Clarimon, J., Lleo, A., Bayer, A., Tsuang, D. W., Yu, L., Tsolaki, M., Bossù, P., Spalletta, G., Proitsi, P., Collinge, J., Sorbi, S., Sanchez-Garcia, F., Fox, N. C., Hardy, J., Naranjo, M. C. Deniz, Bosco, P., Clarke, R., Brayne, C., Galimberti, D., Mancuso, M., Matthews, F., Moebus, S., Mecocci, P., Del Zompo, M., Maier, W., Hampel, H., Pilotto, A., Bullido, M., Panza, F., Caffarra, P., Nacmias, B., Gilbert, J. R., Mayhaus, M., Lannefelt, L., Hakonarson, H., Pichler, S., Carrasquillo, M. M., Ingelsson, M., Beekly, D., Alvarez, V., Zou, F., Valladares, O., Younkin, S. G., Coto, E., Hamilton-Nelson, K. L., Gu, W., Razquin, C., Pastor, P., Mateo, I., Owen, M. J., Faber, K. M., Jonsson, P. V., Combarros, O., O'Donovan, M. C., Cantwell, L. B., Soininen, H., Blacker, D., Mead, S., Mosley, T. H., Bennett, D. A., Harris, T. B., Fratiglioni, L., Holmes, C., de Bruijn, R. F., Passmore, P., Montine, T. J., Bettens, K., Rotter, J. I., Brice, A., Morgan, K., Foroud, T. M., Kukull, W. A., Hannequin, D., Powell, J. F., Nalls, M. A., Ritchie, K., Lunetta, K. L., Kauwe, J. S., Boerwinkle, E., Riemenschneider, M., Boada, M., Hiltuenen, M., Martin, E. R., Schmidt, R., Rujescu, D., Wang, L. S., Dartigues, J. F., Mayeux, R., Tzourio, C., Hofman, A., Nöthen, M. M., Graff, C., Psaty, B. M., Jones, L., Haines, J. L., Holmans, P. A., Lathrop, M., Pericak-Vance, M. A., Launer, L. J., Farrer, L. A., van Duijn, C. M., Van Broeckhoven, C., Moskvina, V., Seshadri, S., Williams, J., Schellenberg, G. D., and Amouyel, P., “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.”, Nat Genet, vol. 45, no. 12, pp. 1452-8, 2013.
C. R. Jack, Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., Roberts, R. O., Rocca, W. A., Boeve, B. F., and Petersen, R. C., “An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease.”, Ann Neurol, vol. 71, no. 6, pp. 765-75, 2012.
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J., “Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”, PLoS One, vol. 5, no. 11, p. e13950, 2010.
K. Iqbal, Liu, F., Gong, C. - X., and Grundke-Iqbal, I., “Tau in Alzheimer disease and related tauopathies.”, Curr Alzheimer Res, vol. 7, no. 8, pp. 656-64, 2010.

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