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Up-Regulation
T. Lu, Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T. - H., Kim, H. - M., Drake, D., X Liu, S., Bennett, D. A., Colaiácovo, M. P., and Yankner, B. A., REST and stress resistance in ageing and Alzheimer's disease., Nature, vol. 507, no. 7493, pp. 448-54, 2014.
G. - H. Lee, Jang, B., Choi, H. - S., Kim, H. - J., Park, J. - H., Jeon, Y. - C., Carp, R. I., Kim, Y. - S., and Choi, E. - K., Upregulation of Connexin 43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease., J Alzheimers Dis, vol. 49, no. 4, pp. 1005-19, 2016.
A. K. Tripathi and Singh, N., Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis: Implications for Cerebral Hemorrhage and Sporadic Creutzfeldt-Jakob Disease., J Alzheimers Dis, vol. 51, no. 1, pp. 107-21, 2016.
H. Khodadadi, Salles, É. Lopes, Jarrahi, A., Costigliola, V., Khan, M. B., Yu, J. C., Morgan, J. C., Hess, D. C., Vaibhav, K., Dhandapani, K. M., and Baban, B., Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer's Disease., J Alzheimers Dis, vol. 80, no. 3, pp. 973-977, 2021.
S. Merighi, Battistello, E., Casetta, I., Gragnaniello, D., Poloni, T. Emanuele, Medici, V., Cirrincione, A., Varani, K., Vincenzi, F., Borea, P. Andrea, and Gessi, S., Upregulation of Cortical A2A Adenosine Receptors Is Reflected in Platelets of Patients with Alzheimer's Disease., J Alzheimers Dis, vol. 80, no. 3, pp. 1105-1117, 2021.
United States
M. Edwards, Hall, J., Williams, B., Johnson, L., and O'Bryant, S., Molecular markers of amnestic mild cognitive impairment among Mexican Americans., J Alzheimers Dis, vol. 49, no. 1, pp. 221-8, 2016.
C. R. Jack, Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., Roberts, R. O., Rocca, W. A., Boeve, B. F., and Petersen, R. C., An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease., Ann Neurol, vol. 71, no. 6, pp. 765-75, 2012.
G. W. Rebok, Ball, K., Guey, L. T., Jones, R. N., Kim, H. - Y., King, J. W., Marsiske, M., Morris, J. N., Tennstedt, S. L., Unverzagt, F. W., and Willis, S. L., Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults., J Am Geriatr Soc, vol. 62, no. 1, pp. 16-24, 2014.
B. T. Hyman, Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., Nelson, P. T., Schneider, J. A., Thal, D. Rudolf, Thies, B., Trojanowski, J. Q., Vinters, H. V., and Montine, T. J., National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease., Alzheimers Dement, vol. 8, no. 1, pp. 1-13, 2012.
G. M. McKhann, Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., Mohs, R. C., Morris, J. C., Rossor, M. N., Scheltens, P., Carrillo, M. C., Thies, B., Weintraub, S., and Phelps, C. H., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease., Alzheimers Dement, vol. 7, no. 3, pp. 263-9, 2011.
M. S. Albert, DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., Snyder, P. J., Carrillo, M. C., Thies, B., and Phelps, C. H., The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease., Alzheimers Dement, vol. 7, no. 3, pp. 270-9, 2011.
R. A. Sperling, Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., Park, D. C., Reiman, E. M., Rowe, C. C., Siemers, E., Stern, Y., Yaffe, K., Carrillo, M. C., Thies, B., Morrison-Bogorad, M., Wagster, M. V., and Phelps, C. H., Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease., Alzheimers Dement, vol. 7, no. 3, pp. 280-92, 2011.
P. S. Aisen, Andrieu, S., Sampaio, C., Carrillo, M., Khachaturian, Z. S., Dubois, B., Feldman, H. H., Petersen, R. C., Siemers, E., Doody, R. S., Hendrix, S. B., Grundman, M., Schneider, L. S., Schindler, R. J., Salmon, E., Potter, W. Z., Thomas, R. G., Salmon, D., Donohue, M., Bednar, M. M., Touchon, J., and Vellas, B., Report of the task force on designing clinical trials in early (predementia) AD., Neurology, vol. 76, no. 3, pp. 280-6, 2011.
D. R. Royall, Palmer, R. F., Matsuoka, T., Kato, Y., Taniguchi, S., Ogawa, M., Fujimoto, H., Okamura, A., Shibata, K., Nakamura, K., Nakaaki, S., Koumi, H., Mimura, M., Fukui, K., and Narumoto, J., Greater than the Sum of Its Parts: δ can be Constructed from Item Level Data., J Alzheimers Dis, vol. 49, no. 2, pp. 571-9, 2016.
E. Kuźma, Soni, M., Littlejohns, T. J., Ranson, J. M., van Schoor, N. M., Deeg, D. J. H., Comijs, H., Chaves, P. H. M., Kestenbaum, B. R., Kuller, L. H., Lopez, O. L., Becker, J. T., Langa, K. M., Henley, W. E., Lang, I. A., Ukoumunne, O. C., and Llewellyn, D. J., Vitamin D and Memory Decline: Two Population-Based Prospective Studies., J Alzheimers Dis, vol. 50, no. 4, pp. 1099-108, 2016.
C. LoBue, Denney, D., Hynan, L. S., Rossetti, H. C., Lacritz, L. H., Hart, J., Womack, K. B., Woon, F. L., and C Cullum, M., Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis., J Alzheimers Dis, vol. 51, no. 3, pp. 727-36, 2016.
P. J. Lao, Handen, B. L., Betthauser, T. J., Mihaila, I., Hartley, S. L., Cohen, A. D., Tudorascu, D. L., Bulova, P. D., Lopresti, B. J., Tumuluru, R. V., Murali, D., Mathis, C. A., Barnhart, T. E., Stone, C. K., Price, J. C., Devenny, D. A., Johnson, S. C., Klunk, W. E., and Christian, B. T., Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome., J Alzheimers Dis, vol. 61, no. 2, pp. 631-644, 2018.
M. L. Alosco, Duskin, J., Besser, L. M., Martin, B., Chaisson, C. E., Gunstad, J., Kowall, N. W., McKee, A. C., Stern, R. A., and Tripodis, Y., Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set., J Alzheimers Dis, vol. 57, no. 3, pp. 953-968, 2017.
M. A. Beydoun, Gamaldo, A. A., Beydoun, H. A., Shaked, D., Zonderman, A. B., and Eid, S. M., Trends, Predictors, and Outcomes of Healthcare Resources Used in Patients Hospitalized with Alzheimer's Disease with at Least One Procedure: The Nationwide Inpatient Sample., J Alzheimers Dis, vol. 57, no. 3, pp. 813-824, 2017.
E. Galkina Cleary, Cifuentes, M., Grinstein, G., Brugge, D., and Shea, T. B., Association of Low-Level Ozone with Cognitive Decline in Older Adults., J Alzheimers Dis, vol. 61, no. 1, pp. 67-78, 2018.

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