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Genetic Counseling
M. Bocchetta, Mega, A., Bernardi, L., Di Maria, E., Benussi, L., Binetti, G., Borroni, B., Colao, R., Di Fede, G., Fostinelli, S., Galimberti, D., Gennarelli, M., Ghidoni, R., Piaceri, I., Pievani, M., Porteri, C., Redaelli, V., Rossi, G., Suardi, S., Babiloni, C., Scarpini, E., Tagliavini, F., Padovani, A., Nacmias, B., Sorbi, S., Frisoni, G. B., and Bruni, A. C., “Genetic Counseling and Testing for Alzheimer's Disease and Frontotemporal Lobar Degeneration: An Italian Consensus Protocol.”, J Alzheimers Dis, vol. 51, no. 1, pp. 277-91, 2016.
Genetic Predisposition to Disease
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J., “Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”, PLoS One, vol. 5, no. 11, p. e13950, 2010.
Genetic Testing
M. Bocchetta, Mega, A., Bernardi, L., Di Maria, E., Benussi, L., Binetti, G., Borroni, B., Colao, R., Di Fede, G., Fostinelli, S., Galimberti, D., Gennarelli, M., Ghidoni, R., Piaceri, I., Pievani, M., Porteri, C., Redaelli, V., Rossi, G., Suardi, S., Babiloni, C., Scarpini, E., Tagliavini, F., Padovani, A., Nacmias, B., Sorbi, S., Frisoni, G. B., and Bruni, A. C., “Genetic Counseling and Testing for Alzheimer's Disease and Frontotemporal Lobar Degeneration: An Italian Consensus Protocol.”, J Alzheimers Dis, vol. 51, no. 1, pp. 277-91, 2016.
Genetic Variation
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
Genome, Human
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J., “Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”, PLoS One, vol. 5, no. 11, p. e13950, 2010.
Genome-Wide Association Study
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J., “Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”, PLoS One, vol. 5, no. 11, p. e13950, 2010.
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
Genotype
A. Montesanto, Crocco, P., Anfossi, M., Smirne, N., Puccio, G., Colao, R., Maletta, R., Passarino, G., Bruni, A. C., and Rose, G., “The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1265-74, 2016.
Geography
E. L. Paley, Merkulova-Rainon, T., Faynboym, A., Shestopalov, V. I., and Aksenoff, I., “Geographical Distribution and Diversity of Gut Microbial NADH:Ubiquinone Oxidoreductase Sequence Associated with Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1531-1540, 2018.
Glycogen Synthase Kinase 3
D. Chu, Tan, J., Xie, S., Jin, N., Yin, X., Gong, C. - X., Iqbal, K., and Liu, F., “GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.”, J Alzheimers Dis, vol. 49, no. 2, pp. 365-75, 2016.
Glycogen Synthase Kinase 3 beta
D. Chu, Tan, J., Xie, S., Jin, N., Yin, X., Gong, C. - X., Iqbal, K., and Liu, F., “GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.”, J Alzheimers Dis, vol. 49, no. 2, pp. 365-75, 2016.
Growth Differentiation Factors
W. Zhang, Guo, Y., Li, B., Zhang, Q., Liu, J. - H., Gu, G. - J., Wang, J. - H., Bao, R. - K., Chen, Y. - J., and Xu, J. - R., “GDF11 Rejuvenates Cerebrovascular Structure and Function in an Animal Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 62, no. 2, pp. 807-819, 2018.
Heterozygote
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
Homocysteine
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
Host-Pathogen Interactions
E. L. Paley, Merkulova-Rainon, T., Faynboym, A., Shestopalov, V. I., and Aksenoff, I., “Geographical Distribution and Diversity of Gut Microbial NADH:Ubiquinone Oxidoreductase Sequence Associated with Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1531-1540, 2018.
Humans
G. He, Luo, W., Li, P., Remmers, C., Netzer, W. J., Hendrick, J., Bettayeb, K., Flajolet, M., Gorelick, F., Wennogle, L. P., and Greengard, P., “Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.”, Nature, vol. 467, no. 7311, pp. 95-8, 2010.
L. Jones, Holmans, P. A., Hamshere, M. L., Harold, D., Moskvina, V., Ivanov, D., Pocklington, A., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Pahwa, J. Singh, Jones, N., Stretton, A., Morgan, A. R., Lovestone, S., Powell, J., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K. S., Passmore, P. A., Craig, D., McGuinness, B., Todd, S., Holmes, C., Mann, D., A Smith, D., Love, S., Kehoe, P. G., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Schürmann, B., Heun, R., Kölsch, H., van den Bussche, H., Heuser, I., Peters, O., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A. M., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Mühleisen, T. W., Nöthen, M. M., Moebus, S., Jöckel, K. - H., Klopp, N., Wichmann, H. - E., Rüther, E., Carrasquillo, M. M., V Pankratz, S., Younkin, S. G., Hardy, J., O'Donovan, M. C., Owen, M. J., and Williams, J., “Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.”, PLoS One, vol. 5, no. 11, p. e13950, 2010.
A. Montesanto, Crocco, P., Anfossi, M., Smirne, N., Puccio, G., Colao, R., Maletta, R., Passarino, G., Bruni, A. C., and Rose, G., “The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1265-74, 2016.
J. Spiegel, Pirraglia, E., Osorio, R. S., Glodzik, L., Li, Y., Tsui, W., Louis, L. A. Saint, Randall, C., Butler, T., Xu, J., Zinkowski, R. P., Zetterberg, H., Fortea, J., Fossati, S., Wisniewski, T., Davies, P., Blennow, K., and de Leon, M. J., “Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease.”, J Alzheimers Dis, vol. 49, no. 1, pp. 93-100, 2016.
D. R. Royall, Palmer, R. F., Matsuoka, T., Kato, Y., Taniguchi, S., Ogawa, M., Fujimoto, H., Okamura, A., Shibata, K., Nakamura, K., Nakaaki, S., Koumi, H., Mimura, M., Fukui, K., and Narumoto, J., “Greater than the Sum of Its Parts: δ can be Constructed from Item Level Data.”, J Alzheimers Dis, vol. 49, no. 2, pp. 571-9, 2016.
D. Chu, Tan, J., Xie, S., Jin, N., Yin, X., Gong, C. - X., Iqbal, K., and Liu, F., “GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.”, J Alzheimers Dis, vol. 49, no. 2, pp. 365-75, 2016.
S. Kim, Nho, K., Ramanan, V. K., Lai, D., Foroud, T. M., Lane, K., Murrell, J. R., Gao, S., Hall, K. S., Unverzagt, F. W., Baiyewu, O., Ogunniyi, A., Gureje, O., Kling, M. A., P Doraiswamy, M., Kaddurah-Daouk, R., Hendrie, H. C., and Saykin, A. J., “Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.”, J Alzheimers Dis, vol. 49, no. 4, pp. 991-1003, 2016.
M. Bocchetta, Mega, A., Bernardi, L., Di Maria, E., Benussi, L., Binetti, G., Borroni, B., Colao, R., Di Fede, G., Fostinelli, S., Galimberti, D., Gennarelli, M., Ghidoni, R., Piaceri, I., Pievani, M., Porteri, C., Redaelli, V., Rossi, G., Suardi, S., Babiloni, C., Scarpini, E., Tagliavini, F., Padovani, A., Nacmias, B., Sorbi, S., Frisoni, G. B., and Bruni, A. C., “Genetic Counseling and Testing for Alzheimer's Disease and Frontotemporal Lobar Degeneration: An Italian Consensus Protocol.”, J Alzheimers Dis, vol. 51, no. 1, pp. 277-91, 2016.
N. Bagheri, Wangdi, K., Cherbuin, N., and Anstey, K. J., “General Practice Clinical Data Help Identify Dementia Hotspots: A Novel Geospatial Analysis Approach.”, J Alzheimers Dis, vol. 61, no. 1, pp. 125-134, 2018.
E. L. Paley, Merkulova-Rainon, T., Faynboym, A., Shestopalov, V. I., and Aksenoff, I., “Geographical Distribution and Diversity of Gut Microbial NADH:Ubiquinone Oxidoreductase Sequence Associated with Alzheimer's Disease.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1531-1540, 2018.

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