Biblio

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Intention to Treat Analysis
S. Salloway, Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., Reichert, M., Ketter, N., Nejadnik, B., Guenzler, V., Miloslavsky, M., Wang, D., Lu, Y., Lull, J., Tudor, I. Cristina, Liu, E., Grundman, M., Yuen, E., Black, R., and H Brashear, R., “Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.”, N Engl J Med, vol. 370, no. 4, pp. 322-33, 2014.
R. S. Doody, Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., Siemers, E., Liu-Seifert, H., and Mohs, R., “Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease.”, N Engl J Med, vol. 370, no. 4, pp. 311-21, 2014.
Intercellular Signaling Peptides and Proteins
E. Morenas-Rodriguez, Cervera-Carles, L., Vilaplana, E., Alcolea, D., Carmona-Iragui, M., Dols-Icardo, O., Ribosa-Nogué, R., Muñoz-Llahuna, L., Sala, I., M Sánchez-Saudinós, B., Blesa, R., Clarimón, J., Fortea, J., and Lleo, A., “Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias.”, J Alzheimers Dis, vol. 50, no. 2, pp. 539-46, 2016.
E. Premi, Cauda, F., Costa, T., Diano, M., Gazzina, S., Gualeni, V., Alberici, A., Archetti, S., Magoni, M., Gasparotti, R., Padovani, A., and Borroni, B., “Looking for Neuroimaging Markers in Frontotemporal Lobar Degeneration Clinical Trials: A Multi-Voxel Pattern Analysis Study in Granulin Disease.”, J Alzheimers Dis, vol. 51, no. 1, pp. 249-62, 2016.
K. Hensley and Kursula, P., “Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau.”, J Alzheimers Dis, vol. 53, no. 1, pp. 1-14, 2016.
Interferon Type I
S. X. Naughton, Raval, U., and Pasinetti, G. M., “Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies.”, J Alzheimers Dis, vol. 76, no. 1, pp. 21-25, 2020.
Interferon-alpha
K. Bourgade, Le Page, A., Bocti, C., Witkowski, J. M., Dupuis, G., Frost, E. H., and Fülöp, T., “Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model.”, J Alzheimers Dis, vol. 50, no. 4, pp. 1227-41, 2016.
B. Su Mee Hui, Zhi, L. Rui, Retinasamy, T., Arulsamy, A., Law, C. Shing Wei, Shaikh, M. Farooq, and Yeong, K. Yoon, “The Role of Interferon-α in Neurodegenerative Diseases: A Systematic Review.”, J Alzheimers Dis, vol. 94, no. s1, pp. S45-S66, 2023.
Interferon-gamma
F. Pasquier, Sadowsky, C., Holstein, A., Leterme, G. Le Prince, Peng, Y., Jackson, N., Fox, N. C., Ketter, N., Liu, E., and J Ryan, M., “Two Phase 2 Multiple Ascending-Dose Studies of Vanutide Cridificar (ACC-001) and QS-21 Adjuvant in Mild-to-Moderate Alzheimer's Disease.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1131-43, 2016.
Interleukin-1 Receptor-Like 1 Protein
Y. Jayne Tan, Siow, I., Saffari, S. Ehsan, Ting, S. K. S., Li, Z., Kandiah, N., Tan, L. C. S., Tan, E. King, and Ng, A. S. L., “Plasma Soluble ST2 Levels Are Higher in Neurodegenerative Disorders and Associated with Poorer Cognition.”, J Alzheimers Dis, vol. 92, no. 2, pp. 573-580, 2023.
Interleukin-10
K. Deniz, Ho, C. C. G., Malphrus, K. G., Reddy, J. S., Nguyen, T., Carnwath, T. P., Crook, J. E., Lucas, J. A., Graff-Radford, N. R., Carrasquillo, M. M., and Ertekin-Taner, N., “Plasma Biomarkers of Alzheimer's Disease in African Americans.”, J Alzheimers Dis, vol. 79, no. 1, pp. 323-334, 2021.
T. June Yoo, “Anti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 85, no. 3, pp. 1001-1008, 2022.
Interleukin-17
T. Saksida, Koprivica, I., Vujičić, M., Stošić-Grujičić, S., Perović, M., Kanazir, S., and Stojanović, I., “Impaired IL-17 Production in Gut-Residing Immune Cells of 5xFAD Mice with Alzheimer's Disease Pathology.”, J Alzheimers Dis, vol. 61, no. 2, pp. 619-630, 2018.
Interleukin-1beta
K. Bourgade, Le Page, A., Bocti, C., Witkowski, J. M., Dupuis, G., Frost, E. H., and Fülöp, T., “Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model.”, J Alzheimers Dis, vol. 50, no. 4, pp. 1227-41, 2016.
Interleukin-33
H. Khodadadi, Salles, É. Lopes, Jarrahi, A., Costigliola, V., Khan, M. B., Yu, J. C., Morgan, J. C., Hess, D. C., Vaibhav, K., Dhandapani, K. M., and Baban, B., “Cannabidiol Ameliorates Cognitive Function via Regulation of IL-33 and TREM2 Upregulation in a Murine Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 80, no. 3, pp. 973-977, 2021.
Y. Jayne Tan, Siow, I., Saffari, S. Ehsan, Ting, S. K. S., Li, Z., Kandiah, N., Tan, L. C. S., Tan, E. King, and Ng, A. S. L., “Plasma Soluble ST2 Levels Are Higher in Neurodegenerative Disorders and Associated with Poorer Cognition.”, J Alzheimers Dis, vol. 92, no. 2, pp. 573-580, 2023.
Interleukin-4
T. June Yoo, “Anti-Inflammatory Gene Therapy Improves Spatial Memory Performance in a Mouse Model of Alzheimer's Disease.”, J Alzheimers Dis, vol. 85, no. 3, pp. 1001-1008, 2022.
Interleukin-6
N. Iwahara, Hisahara, S., Kawamata, J., Matsumura, A., Yokokawa, K., Saito, T., Fujikura, M., Manabe, T., Suzuki, H., Matsushita, T., Suzuki, S., and Shimohama, S., “Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice.”, J Alzheimers Dis, vol. 55, no. 3, pp. 1235-1247, 2017.
B. Gurel, Cansev, M., Sevinc, C., Kelestemur, S., Ocalan, B., Cakir, A., Aydin, S., Kahveci, N., Ozansoy, M., Taskapilioglu, O., Ulus, I. Hakki, Başar, M. Karayel, Sahin, B., Tuzuner, M. Bora, and Baykal, A. Tarik, “Early Stage Alterations in CA1 Extracellular Region Proteins Indicate Dysregulation of IL6 and Iron Homeostasis in the 5XFAD Alzheimer's Disease Mouse Model.”, J Alzheimers Dis, vol. 61, no. 4, pp. 1399-1410, 2018.
K. Deniz, Ho, C. C. G., Malphrus, K. G., Reddy, J. S., Nguyen, T., Carnwath, T. P., Crook, J. E., Lucas, J. A., Graff-Radford, N. R., Carrasquillo, M. M., and Ertekin-Taner, N., “Plasma Biomarkers of Alzheimer's Disease in African Americans.”, J Alzheimers Dis, vol. 79, no. 1, pp. 323-334, 2021.
N. Shu Ning Teoh, Gyanwali, B., Lai, M. K. P., Chai, Y. Ling, Chong, J. R., Chong, E. Jun Yi, Chen, C., Tan, C. Seng, and Hilal, S., “Association of Interleukin-6 and Interleukin-8 with Cognitive Decline in an Asian Memory Clinic Population.”, J Alzheimers Dis, vol. 92, no. 2, pp. 445-455, 2023.
Interleukin-8
N. Shu Ning Teoh, Gyanwali, B., Lai, M. K. P., Chai, Y. Ling, Chong, J. R., Chong, E. Jun Yi, Chen, C., Tan, C. Seng, and Hilal, S., “Association of Interleukin-6 and Interleukin-8 with Cognitive Decline in an Asian Memory Clinic Population.”, J Alzheimers Dis, vol. 92, no. 2, pp. 445-455, 2023.
International Cooperation
B. Dubois, Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. Luis, Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., Cappa, S., Crutch, S., Engelborghs, S., Frisoni, G. B., Fox, N. C., Galasko, D., Habert, M. - O., Jicha, G. A., Nordberg, A., Pasquier, F., Rabinovici, G., Robert, P., Rowe, C., Salloway, S., Sarazin, M., Epelbaum, S., de Souza, L. C., Vellas, B., Visser, P. J., Schneider, L., Stern, Y., Scheltens, P., and Cummings, J. L., “Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.”, Lancet Neurol, vol. 13, no. 6, pp. 614-29, 2014.
P. S. Aisen, Andrieu, S., Sampaio, C., Carrillo, M., Khachaturian, Z. S., Dubois, B., Feldman, H. H., Petersen, R. C., Siemers, E., Doody, R. S., Hendrix, S. B., Grundman, M., Schneider, L. S., Schindler, R. J., Salmon, E., Potter, W. Z., Thomas, R. G., Salmon, D., Donohue, M., Bednar, M. M., Touchon, J., and Vellas, B., “Report of the task force on designing clinical trials in early (predementia) AD.”, Neurology, vol. 76, no. 3, pp. 280-6, 2011.
H. Florian, Meier, A., Gauthier, S., Lipschitz, S., Lin, Y., Tang, Q., Othman, A. A., Robieson, W. Z., and Gault, L. M., “Efficacy and Safety of ABT-126 in Subjects with Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Study.”, J Alzheimers Dis, vol. 51, no. 4, pp. 1237-47, 2016.

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