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Phosphorylation
J. C. Morris, Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., and Mintun, M. A., “APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.”, Ann Neurol, vol. 67, no. 1, pp. 122-31, 2010.
M. Jin, Shepardson, N., Yang, T., Chen, G., Walsh, D., and Selkoe, D. J., “Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.”, Proc Natl Acad Sci U S A, vol. 108, no. 14, pp. 5819-24, 2011.
K. Iqbal, Liu, F., Gong, C. - X., and Grundke-Iqbal, I., “Tau in Alzheimer disease and related tauopathies.”, Curr Alzheimer Res, vol. 7, no. 8, pp. 656-64, 2010.
M. Bolós, Llorens-Martín, M., Jurado-Arjona, J., Hernández, F., Rábano, A., and Avila, J., “Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.”, J Alzheimers Dis, vol. 50, no. 1, pp. 77-87, 2016.
C. Deochand, Tong, M., Agarwal, A. R., Cadenas, E., and de la Monte, S. M., “Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration.”, J Alzheimers Dis, vol. 50, no. 2, pp. 373-86, 2016.
S. Hoon Choi, Kim, Y. Hye, Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., and Kim, D. Yeon, “A three-dimensional human neural cell culture model of Alzheimer's disease.”, Nature, vol. 515, no. 7526, pp. 274-8, 2014.
S. Salloway, Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., Reichert, M., Ketter, N., Nejadnik, B., Guenzler, V., Miloslavsky, M., Wang, D., Lu, Y., Lull, J., Tudor, I. Cristina, Liu, E., Grundman, M., Yuen, E., Black, R., and H Brashear, R., “Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.”, N Engl J Med, vol. 370, no. 4, pp. 322-33, 2014.
K. Talbot, Wang, H. - Y., Kazi, H., Han, L. - Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., Arvanitakis, Z., Schneider, J. A., Wolf, B. A., Bennett, D. A., Trojanowski, J. Q., and Arnold, S. E., “Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.”, J Clin Invest, vol. 122, no. 4, pp. 1316-38, 2012.
J. Gräff, Rei, D., Guan, J. - S., Wang, W. - Y., Seo, J., Hennig, K. M., Nieland, T. J. F., Fass, D. M., Kao, P. F., Kahn, M., Su, S. C., Samiei, A., Joseph, N., Haggarty, S. J., Delalle, I., and Tsai, L. - H., “An epigenetic blockade of cognitive functions in the neurodegenerating brain.”, Nature, vol. 483, no. 7388, pp. 222-6, 2012.
F. Piazza, Greenberg, S. M., Savoiardo, M., Gardinetti, M., Chiapparini, L., Raicher, I., Nitrini, R., Sakaguchi, H., Brioschi, M., Billo, G., Colombo, A., Lanzani, F., Piscosquito, G., Carriero, M. Rita, Giaccone, G., Tagliavini, F., Ferrarese, C., and DiFrancesco, J. C., “Anti-amyloid β autoantibodies in cerebral amyloid angiopathy-related inflammation: implications for amyloid-modifying therapies.”, Ann Neurol, vol. 73, no. 4, pp. 449-58, 2013.
J. Spiegel, Pirraglia, E., Osorio, R. S., Glodzik, L., Li, Y., Tsui, W., Louis, L. A. Saint, Randall, C., Butler, T., Xu, J., Zinkowski, R. P., Zetterberg, H., Fortea, J., Fossati, S., Wisniewski, T., Davies, P., Blennow, K., and de Leon, M. J., “Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease.”, J Alzheimers Dis, vol. 49, no. 1, pp. 93-100, 2016.
J. C. Triplett, Swomley, A. M., Cai, J., Klein, J. B., and D Butterfield, A., “Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease.”, J Alzheimers Dis, vol. 49, no. 1, pp. 45-62, 2016.
G. Berge, Lauridsen, C., Sando, S. Botne, Holder, D. Joseph, Møller, I., Aasly, J. Olav, Bråthen, G., Savage, M. Josephine, and White, L. Rosemary, “Effect of Tween-20 on Core Biomarkers Measured in Cerebrospinal Fluid from Patients with Alzheimer's Disease, Mild Cognitive Impairment, or Healthy Control Individuals.”, J Alzheimers Dis, vol. 49, no. 2, pp. 493-502, 2016.
D. Chu, Tan, J., Xie, S., Jin, N., Yin, X., Gong, C. - X., Iqbal, K., and Liu, F., “GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.”, J Alzheimers Dis, vol. 49, no. 2, pp. 365-75, 2016.
A. F. N. Rosenberger, Hilhorst, R., Coart, E., Barrado, L. García, Naji, F., Rozemuller, A. J. M., van der Flier, W. M., Scheltens, P., Hoozemans, J. J. M., and van der Vies, S. M., “Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer's Disease Pathology.”, J Alzheimers Dis, vol. 49, no. 4, pp. 927-43, 2016.
Y. Shan, Wang, D. - D., Xu, Y. - X., Wang, C., Cao, L., Liu, Y. - S., and Zhu, C. - Q., “Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid.”, J Alzheimers Dis, vol. 49, no. 3, pp. 829-44, 2016.
N. Bartolotti, Segura, L., and Lazarov, O., “Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease Mice.”, J Alzheimers Dis, vol. 50, no. 2, pp. 477-89, 2016.
H. Qiu, Zhong, R., Liu, H., Zhang, F., Li, S., and Le, W., “Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer's Disease-Like Pathologies in AβPP(swe)/PS1(ΔE9) Mice.”, J Alzheimers Dis, vol. 50, no. 3, pp. 669-85, 2016.
H. Jin, Chen, T., Li, G., Wang, C., Zhang, B., Cao, X., Sha, S., Wan, Q., and Chen, L., “Dose-Dependent Neuroprotection and Neurotoxicity of Simvastatin through Reduction of Farnesyl Pyrophosphate in Mice Treated with Intracerebroventricular Injection of Aβ 1-42.”, J Alzheimers Dis, vol. 50, no. 2, pp. 501-16, 2016.
G. Koch, Di Lorenzo, F., Del Olmo, M. Fernandez, Bonní, S., Ponzo, V., Caltagirone, C., Bozzali, M., and Martorana, A., “Reversal of LTP-Like Cortical Plasticity in Alzheimer's Disease Patients with Tau-Related Faster Clinical Progression.”, J Alzheimers Dis, vol. 50, no. 2, pp. 605-16, 2016.
C. -cui Yang, Kuai, X. -xian, bin Gao, W. -, Yu, J. -chun, Wang, Q., Li, L., and Zhang, L., “Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.”, J Alzheimers Dis, vol. 51, no. 1, pp. 33-44, 2016.
C. Huang, Ng, O. Tsz- Wa, Ho, Y. - S., Irwin, M. Garnet, Chang, R. Chuen- Chun, and Wong, G. Tin- Chun, “Effect of Continuous Propofol Infusion in Rat on Tau Phosphorylation with or without Temperature Control.”, J Alzheimers Dis, vol. 51, no. 1, pp. 213-26, 2016.
L. Chang, Zhang, Y., Liu, J., Song, Y., Lv, A., Li, Y., Zhou, W., Yan, Z., Almeida, O. F. X., and Wu, Y., “Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is an Early Event in the Actions of Soluble Amyloid-β(1-40) Oligomers on Hippocampal Neurons.”, J Alzheimers Dis, vol. 51, no. 1, pp. 197-212, 2016.
X. - P. Hong, Chen, T., Yin, N. - N., Han, Y. - M., Yuan, F., Duan, Y. - J., Shen, F., Zhang, Y. - H., and Bin Chen, Z. -, “Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain.”, J Alzheimers Dis, vol. 51, no. 2, pp. 605-17, 2016.
B. N. Dugger, Whiteside, C. M., Maarouf, C. L., Walker, D. G., Beach, T. G., Sue, L. I., Garcia, A., Dunckley, T., Meechoovet, B., Reiman, E. M., and Roher, A. E., “The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease.”, J Alzheimers Dis, vol. 51, no. 2, pp. 345-56, 2016.

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