Cognitive reserve in ageing and Alzheimer's disease.

Stern Y
Lancet Neurol. 2012 Nov; 11(11):1006-12. PMID: 23079557. Abstract
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This paper provides a detailed and incisive overview of one of the most interesting hypothesis formulated in the field, i.e. cognitive reserve as explanation for inter-individual differences in functional changes due to AD and as potential target to slow down cognitive aging or reduce risk of dementia.

This paper is a seminal work for the definition of both cognitive reserve and brain reserve and to understanding their role in the natural history of Alzheimer's disease.