23 June 2023
Phone Menu Test Detects Who May Be at Risk of Alzheimer’s Disease
A new study by investigators from Mass General Brigham has found that a brief, simulated task of navigating a phone menu can detect the earliest changes in daily functioning in people at risk of developing Alzheimer’s disease. Investigators found that an older adult’s performance on the test, which can be completed in a matter of minutes, was associated with the hallmarks of Alzheimer’s disease pathology, including amyloid and tau depositions in the brain. The findings could help inform prevention trials testing treatments for Alzheimer’s disease before pronounced symptoms of cognitive decline begin.
22 June 2023
Significant Correlation Found between Vitreous Human Biomarkers and Alzheimer’s Disease
New research from Boston Medical Center found a significant correlation between biomarkers in the vitreous humor of the eye and pathologically confirmed cases of Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE) in post-mortem brain and eye tissue. This exploratory study indicates that biomarkers in the vitreous humor may serve as a proxy for neuropathological disease.
19 June 2023
New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.
14 June 2023
Traumatic brain injury raises risk of brain atrophy
A new autopsy study from researchers at the University of Washington School of Medicine, Mount Sinai School of Medicine, and Kaiser Permanente Health Research Institute has found that people who reported having lost consciousness after sustaining a traumatic brain injury faced a higher risk of brain atrophy, but not the changes associated with Alzheimer’s and related dementias.
24 May 2023
Case Study Reveals Potentially Lethal Side Effects of Lecanemab for Treatment of Alzheimer's Disease
In a noteworthy case study published in the Journal of Alzheimer’s Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer’s disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab. Four days after the last infusion, she experienced stroke symptoms and died several days later due to multifocal intracerebral hemorrhage despite attempts at therapeutic intervention. Neuropathologic findings reflected therapy-induced Aβ phagocytosis involving fibrillar Aβ both in the parenchymal brain tissue and in the cerebral vasculature.
13 May 2023
Air Pollution May Increase Risk of Dementia, Complicated by Genetics
Writing in the May 2, 2023 issue of the Journal of Alzheimer’s Disease, a team of researchers, led by scientists at University of California San Diego, further elaborate on how exposure to ambient air pollution, such as car exhaust and power plant emissions, is associated with a measurably greater risk of developing dementia over time.
26 April 2023
The beneficial effects of music on memory may depend on how it is listened to
The initial results of the study of the 'Mozart effect' on neurodegeneration show that listening to classical music in the background has no benefits for learning. The research has been carried out with people experiencing mild cognitive impairment, and it did find individual differences when listening to 'high-arousal' music.
4 April 2023
Depression and the Absence of a Stable Partner Can Accelerate Alzheimer’s Disease in People with Genetic Risk
Depressive symptoms and the absence of a stable partner can accelerate the progression of Alzheimer's disease in people who carry a genetic mutation. In addition, adequate treatment and controls in people with thyroid problems help delay depressive symptoms, progression to dementia, and death. These findings were reached by a team of researchers from the Universidad de Antioquia, Colombia, Universidad Nacional de Colombia, and Hamburg-Eppendorf University Medical Center, Germany, in a population with the "paisa mutation" or presenilin 1, E280A mutation carriers, for early-onset Alzheimer's disease.
9 March 2023
Researchers from Rowan University and Durin Technologies announce highly accurate blood test for Alzheimer’s Disease
A team of researchers from Rowan-Virtua School of Osteopathic Medicine (Rowan-Virtua SOM) and Durin Technologies, Inc., have announced the results of a newly-designed blood test that can detect the presence of Alzheimer’s disease-related pathology up to 10 years before symptoms arise with a nearly 97 percent accuracy rate. Their findings appear online ahead of press in the Journal of Alzheimer’s Disease.
9 March 2023
New Cleveland Clinic-Developed Screening Tool Can Assess Cognition Issues in Older Adults
A self-administered screening tool, developed by Cleveland Clinic researchers, can effectively and efficiently assess cognition issues in older adults. A new study found that the simple test taken on a tablet computer before an annual physical is conducive to use in a primary care setting for detecting mild cognitive impairment, early Alzheimer’s disease, and other related dementias. Results were published in Journal of Alzheimer’s Disease.
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