Alzheimer’s disease-like neurodegeneration in Porphyromonas gingivalis infected neurons with persistent expression of active gingipains

Manuscript Number: 

20-0393

Author(s): 
Shirin Arastu-Kapur, Sean Broce, Thomas Cecere, Stephen S. Dominy, Florian Ermini, Ursula Haditsch, Sandy Hancock, Leslie J. Holsinger, Casey C. Lynch, Mai Nguyen, Debasish Raha, Leo Rodriguez, Theresa Roth

Disclosures

Shirin Arastu-Kapur

  • Equity:
    Cortexyme
    Sponsors:
    Senior Director

Sean Broce

  • Sponsors:
    Scientist I

Thomas Cecere

  • Nothing to Disclose

Stephen S. Dominy

  • Equity:
    Cortexyme stock equity ownership 5.5%
    Sponsors:
    Cortexyme Chief Scientific Officer
    Patents/Royalties
    Co-inventor on two issued patents both entitled "Inhibitors of lysine gingipain" (US/9,975,473 and US/9,988,375) as well as two pending patent applications entitled "Inhibitors of arginine gingipain" (PCT/US2016/061197, filed on 9 November 2016) and "Ketone inhibitors of lysine gingipain" (PCT US2017/051912, filed on 15 September 2017). Co-inventor on a patent application entitled "Methods of use for therapeutic targeting of the pathogen P. gingivalis (US2017/0014468, filed on 29 April 2015). Cortexyme is the assignee these patents and applications.

Florian Ermini

  • Equity:
    Cortexyme stock options.
    Sponsors:
    F.E. is an employee of Cortexyme.

Ursula Haditsch

  • Equity:
    Cortexyme's ISO
    Sponsors:
    Senior Scientist at Cortexyme

Sandy Hancock

  • Nothing to Disclose

Leslie J. Holsinger

  • Equity:
    I possess Incentive Stock options (ISO) and Nonqualified Stock Options (NQ) in Cortexyme
    Sponsors:
    Executive Vice President of Research and Development at Cortexyme

Casey C. Lynch

  • Equity:
    CRTX stock and stock options
    Sponsors:
    Employed by Cortexyme
    Patents/Royalties
    inventor on Cortexyme patents

Mai Nguyen

  • Equity:
    ISO from Cortexyme and employed by Cortexyme.
    Sponsors:
    Employed by Cortexyme.

Debasish Raha

  • Equity:
    Cortexyme stock and others
    Sponsors:
    Cortexyme employee

Leo Rodriguez

  • Sponsors:
    I work for Cortexyme as a Scientist.

Theresa Roth

  • Equity:
    Have stock options available but have not exercised any options
    Sponsors:
    Employed at Cortexyme