Alzheimer’s disease-like neurodegeneration in Porphyromonas gingivalis infected neurons with persistent expression of active gingipains
Manuscript Number:
20-0393
Author(s):
Shirin Arastu-Kapur, Sean Broce, Thomas Cecere, Stephen S. Dominy, Florian Ermini, Ursula Haditsch, Sandy Hancock, Leslie J. Holsinger, Casey C. Lynch, Mai Nguyen, Debasish Raha, Leo Rodriguez, Theresa Roth
Disclosures
Shirin Arastu-Kapur
Equity:
Cortexyme
Sponsors:
Senior Director
Sean Broce
Sponsors:
Scientist I
Thomas Cecere
Nothing to Disclose
Stephen S. Dominy
Equity:
Cortexyme stock equity ownership 5.5%
Sponsors:
Cortexyme Chief Scientific Officer
Patents/Royalties
Co-inventor on two issued patents both entitled "Inhibitors of lysine gingipain" (US/9,975,473 and US/9,988,375) as well as two pending patent applications entitled "Inhibitors of arginine gingipain" (PCT/US2016/061197, filed on 9 November 2016) and "Ketone inhibitors of lysine gingipain" (PCT US2017/051912, filed on 15 September 2017). Co-inventor on a patent application entitled "Methods of use for therapeutic targeting of the pathogen P. gingivalis (US2017/0014468, filed on 29 April 2015). Cortexyme is the assignee these patents and applications.
Florian Ermini
Equity:
Cortexyme stock options.
Sponsors:
F.E. is an employee of Cortexyme.
Ursula Haditsch
Equity:
Cortexyme's ISO
Sponsors:
Senior Scientist at Cortexyme
Sandy Hancock
Nothing to Disclose
Leslie J. Holsinger
Equity:
I possess Incentive Stock options (ISO) and Nonqualified Stock Options (NQ) in Cortexyme
Sponsors:
Executive Vice President of Research and Development at Cortexyme
Casey C. Lynch
Equity:
CRTX stock and stock options
Sponsors:
Employed by Cortexyme
Patents/Royalties
inventor on Cortexyme patents
Mai Nguyen
Equity:
ISO from Cortexyme and employed by Cortexyme.
Sponsors:
Employed by Cortexyme.
Debasish Raha
Equity:
Cortexyme stock and others
Sponsors:
Cortexyme employee
Leo Rodriguez
Sponsors:
I work for Cortexyme as a Scientist.
Theresa Roth
Equity:
Have stock options available but have not exercised any options