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Concepcion Goldberg, MD PhD
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Affiliation(s):
The Feinstein Institute for Medical Research-Northwell Health
Areas of Interest:
Alzheimer's disease, ApoE, tau, phosphorylation, neurodegeneration, mitochondria
Biography & Research:
Concepcion Goldberg MD. PhD., is Assistant Investigator and Director of the Expression Profiling Laboratory at The Litwin-Zucker Research Center for the Study of Alzheimer’s Disease and Memory Disorders, at the Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine in Manhasset, New York. Dr. Goldberg obtained her Medical Degree at the Complutense University of Madrid and received her PhD in Molecular Biology from the same university in 1994. Her thesis work at “Ramon y Cajal” Hospital of Madrid was awarded “cum laudem” with outstanding achievement that same year. Dr. Goldberg was a postdoctoral fellowship at the National Institute of Mental Health at the lab of Dr. William Freed, a leader in neural transplants where she engineered an immortalized cell line to produce GAD67, a critical enzyme in the production of GABA and started focusing in brain diseases. Dr. Goldberg worked as Scientist at the Stanley Brain Research Laboratory during 1999-2005, where she was involved in schizophrenia research and began her work on microarrays in brain post-mortem human tissue. In 2005, she joined the Litwin-Zucker Research Center for the Study of Alzheimer’s Disease where she continued work on human post-mortem tissue from individuals who died having Alzheimer’s disease and/or individuals who carried the risk allele APOE4. Dr. Goldberg’s strategies focus on the etiology of Alzheimer’s disease and the different mechanisms contributing to neurodegeneration. She studies abnormal expression of RNA in brain tissue from people at high risk for Alzheimer’s disease and people with Alzheimer’s disease. Dr. Goldberg is trying to identify novel brain gene expression networks that are involved in the pathological processes that result in a neurodegenerative disease like Alzheimer’s disease, and also, importantly, protective factors so we can better understand brain resilience in the context of aging.