Ramesh Kandimalla, MSc PhD
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Affiliation(s):
Texas Tech University Health Science Center
ORCID URL:
Areas of Interest:
Alzheimer and Parkinson Diseases; Mitochondrial Targeted Therapeutics in Alzheimer's disease, Alzheimer's disease mice models, APP trafficking, phospho-tau, Alzheimer's disease and aluminum, Alzheimer's Disease and aging of the Central nervous System
Biography & Research:
Ramesh Kandimalla, PhD., is Assistant Professor (Res.) at the Texas Tech University of Health Sciences Center (TTUHSC), Lubbock, TX, USA. Dr. Kandimalla obtained his Ph.D. in Neuroscience from Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Dr. Kandimalla received postdoctoral fellowships from McGill University, Montreal, Canada; Emory University, Atlanta, USA and Oregon Health Sciences University, Portland, USA. Dr. Kandimalla worked to develop new animal models of schizophrenia that take into account the purported neurodevelopmental features of the disease including its clinical manifestation following the onset of puberty under the super vision of Dr. Remi Quirion at McGill University. At Emory University under the supervision of Dr. Huichen Wang, Dr. Kandimalla work focused on the mechanism of ionizing radiation (from high energy particles during space mission (NASA)-induced DNA double strand break repair in the central nervous system. Dr. Kandimalla found that radiation increased the neuronal progenitor cell death and reduced neuronal plasticity. Dr. Kandimalla work demonstrated inhibition of GSK3β in protecting neural cells from DNA damage and oxidative stress induced by x-ray, proton and high energy charge particles radiation. In addition, Dr. Kandimalla investigated the effect of amyloid beta on radiation induced DNA damage response in neuronal cells. Dr. Kandimalla got extensive training on the DNA damage response, neuronal stem cell, and neuronal plasticity. Along with this main project Dr. Kandimalla also worked on several of types of DNA repair mechanisms (by using engineered plasmids) in breast cancer and brain tumor. Dr. Kandimalla has shown lot of interest on latest advances in neuroscience like optogenetics, Knock-in / Knock-out Mouse via Cas9-CRISPR technology, Axonal guidance mechanisms, neuronal morphology by an advanced immunochemical technique, and cellular mechanisms of cognition by electrophysiology. Dr. Kandimalla writing skills are highly commendable and have very good teaching skills (Co-Mentored EMORY SURE PROGRAM Student). Dr. Kandimalla involved in Dr. Hemachandra Reddy (2) NIH R01 grants – Dynamin-related Protein 1 and Mitochondrial Fragmentation in Alzheimer’s disease (AG042178) and Voltage-dependent Anion Channel Protein 1 and Neurodegeneration in Alzheimer’s disease (AG047812). Currently Dr. Kandimalla primary focus is on maintaining mouse colonies, including heterozygote knockouts of dynamin-related protein 1 and voltage-dependent anion channel 1, and transgenic lines of amyloid precursor protein and mutant tau mice. He created double mutant lines (Tau X Drp1+/-; APP X Drp1+/-; Tau X VADC+/- and APP X VDAC1+/-) and involved with characterizing for mitochondrial structure/function, synaptic activity and amyloid beta and tau pathologies. Dr. Kandimalla uses multiple techniques and approaches, including molecular biology and cell biology, cell culture and light/fluorescence/confocal microscopies. Dr. Kandimalla is author and/or co-author for more than 35 peer-reviewed articles. Dr. Kandimalla is also reviewer and editor for various neuroscience and biochemistry journals.
