Biography & Research:
Biography:
Subashchandrabose Chinnathambi obtained his Ph.D. in Biochemistry, at the Max Planck Institute for Structural Molecular Biology (MPGASMB), Hamburg, Germany in 2011. He has examined the Influence of Phosphorylation on the Pathological Conformation of Human Microtubule-Associated Protein Tau in Alzheimer’s disease. His post-doctoral training at the German Centre for Neurodegeneration Disease (DZNE)–Bonn, Germany, studied the role of rare MAPT (p. A152T mutant) mutation increases the pathological conformation and physiological properties of Tau (axonal protein) in Alzheimer’s patient. After the post-doctoral stint he joined as Assistant Professor at the Biochemical Sciences Division, National Chemical Laboratory (CSIR-NCL). He has published more than 15 papers in reputed journals. He has expertise in the area of Tau biochemistry and especially on Alzheimer and Parkinson’s disease.
Research Areas
1. Microglial internalization and degradation of post-translational modifications of Tau
2. Phagocytosis of full-length Tau oligomers by actin-remodeling of activated microglia
3. α- Linoleanic acid modulates phagocytosis of extracellular Tau and induces microglial migration by actin-remodeling
4. Signaling cascades of Tau (CDK5, GSK3 beta and their inhibitors)
5. Chaperone mediated Tau Phosphorylation and dynamics in Alzheimer’s disease
6. Understanding the role of dual (Acetylation and Methylation) modifications of Tau in AD