Title | Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Malishkevich, A, Marshall, GA, Schultz, AP, Sperling, RA, Aharon-Peretz, J, Gozes, I |
Journal | J Alzheimers Dis |
Volume | 50 |
Issue | 1 |
Pagination | 249-60 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Chi-Square Distribution, Cognitive Dysfunction, Cohort Studies, Female, Homeodomain Proteins, Humans, Independent Living, Intelligence, Male, Mental Status Schedule, Middle Aged, Nerve Tissue Proteins, Peptide Fragments, RNA, Messenger, tau Proteins |
Abstract | Biomarkers for Alzheimer's disease (AD) are vital for disease detection in the clinical setting. Discovered in our laboratory, activity-dependent neuroprotective protein (ADNP) is essential for brain formation and linked to cognitive functions. Here, we revealed that blood borne expression of ADNP and its paralog ADNP2 is correlated with premorbid intelligence, AD pathology, and clinical stage. Age adjustment showed significant associations between: 1) higher premorbid intelligence and greater serum ADNP, and 2) greater cortical amyloid and lower ADNP and ADNP2 mRNAs. Significant increases in ADNP mRNA levels were observed in patients ranging from mild cognitive impairment (MCI) to AD dementia. ADNP2 transcripts showed high correlation with ADNP transcripts, especially in AD dementia lymphocytes. ADNP plasma/serum and lymphocyte mRNA levels discriminated well between cognitively normal elderly, MCI, and AD dementia participants. Measuring ADNP blood-borne levels could bring us a step closer to effectively screening and tracking AD. |
DOI | 10.3233/JAD-150799 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26639975 |
PubMed Central ID | PMC4712084 |
Grant List | R01 AG037497 / AG / NIA NIH HHS / United States P01 AG036694 / AG / NIA NIH HHS / United States P50 AG005134 / AG / NIA NIH HHS / United States U01 NS082157 / NS / NINDS NIH HHS / United States P50AG005134 / AG / NIA NIH HHS / United States P01 AGO36694 / / PHS HHS / United States |