Title | White Matter Abnormalities Track Disease Progression in PSEN1 Autosomal Dominant Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Sánchez-Valle, R, Monté, GC, Sala-Llonch, R, Bosch, B, Fortea, J, Lladó, A, Antonell, A, Balasa, M, Bargalló, N, Molinuevo, JLuis |
Journal | J Alzheimers Dis |
Volume | 51 |
Issue | 3 |
Pagination | 827-35 |
Date Published | 2016 |
ISSN | 1875-8908 |
Keywords | Adult, Aging, Alzheimer Disease, Brain, Cohort Studies, Diffusion Tensor Imaging, Disease Progression, Family, Female, Heterozygote, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Mutation, Neuropsychological Tests, Organ Size, Presenilin-1, White Matter |
Abstract | PSEN1 mutations are the most frequent cause of autosomal dominant Alzheimer's disease (ADAD), and show nearly full penetrance. There is presently increasing interest in the study of biomarkers that track disease progression in order to test therapeutic interventions in ADAD. We used white mater (WM) volumetric characteristics and diffusion tensor imaging (DTI) metrics to investigate correlations with the normalized time to expected symptoms onset (relative age ratio) and group differences in a cohort of 36 subjects from PSEN1 ADAD families: 22 mutation carriers, 10 symptomatic (SMC) and 12 asymptomatic (AMC), and 14 non-carriers (NC). Subjects underwent a 3T MRI. WM morphometric data and DTI metrics were analyzed. We found that PSEN1 MC showed significant negative correlation between fractional anisotropy (FA) and the relative age ratio in the genus and body of corpus callosum and corona radiate (p |
DOI | 10.3233/JAD-150899 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 26923015 |