Title | Galantamine Response Associates with Agitation and the Prefrontal Cortex in Patients with Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Nakayama, S, Suda, A, Nakanishi, A, Motoi, Y, Hattori, N |
Journal | J Alzheimers Dis |
Volume | 57 |
Issue | 1 |
Pagination | 267-273 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | Behavioral and psychological symptoms of dementia (BPSD) occur in up to 80% of AD patients and represent one of the largest factors contributing to caregiver burden. To analyze the effect of galantamine on BPSD and caregiver burden, we treated a total of 50 patients with mild AD for 12 weeks and evaluated them using the Neuropsychiatric Inventory (NPI) and Japanese version of the Zarit Caregiver Burden Interview (ZBI). We also performed regional cerebral blood flow single photon emission computed tomography (rCBF SPECT) at baseline using three-dimensional sterotatic surface projections. Total NPI and ZBI scores did not significantly change after 12-week galantamine treatment. To identify the characteristics of patients who showed improvement after galantamine treatment, we divided patients into two groups, those with and those without sub-items on the NPI. Patients with aggression showed improvement in ZBI scores (p |
DOI | 10.3233/JAD-160902 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28222509 |