Title | Smoking, APOE Genotype, and Cognitive Decline: The Rotterdam Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Wingbermühle, R, Wen, K-X, Wolters, FJ, M Ikram, A, Bos, D |
Journal | J Alzheimers Dis |
Volume | 57 |
Issue | 4 |
Pagination | 1191-1195 |
Date Published | 2017 |
ISSN | 1875-8908 |
Abstract | The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOEɛ4 genotype. In 5,705 participants (mean age: 63.9±9.1 years; 57.4% women) from the population-based Rotterdam Study, we investigated the relationship between smoking and cognitive decline over a 5.5-year period and examined potential effect modification by APOEɛ4 genotype. We found that current smoking was related to decline in global cognition [difference compared to never smoking: -0.06 (95% C.I.-0.10;-0.01)], as well as decline on specific cognitive tests including the Letter Digit Substitution Task, the 15-Word Learning Test, and the Purdue Pegboard. We found no evidence for effect modification by APOEɛ4 genotype on this relation. |
DOI | 10.3233/JAD-170063 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28304310 |