Title | The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Nielsen, MSchjnning, Simonsen, AHviid, Siersma, V, Hasselbalch, SGregers, Hoegh, P |
Journal | J Alzheimers Dis |
Volume | 61 |
Issue | 3 |
Pagination | 1189-1199 |
Date Published | 2018 |
ISSN | 1875-8908 |
Keywords | Aged, Alzheimer Disease, Biomarkers, Case-Control Studies, Cognitive Dysfunction, Disease Progression, Female, Humans, Logistic Models, Male, Memory, Middle Aged, Neuropsychological Tests, Prognosis, Prospective Studies, ROC Curve |
Abstract | BACKGROUND: Daily living requires the ability to perform dual-tasking. As cognitive skills decrease in dementia, performing a cognitive and motor task simultaneously become increasingly challenging and subtle gait abnormalities may even be present in pre-dementia stages. Therefore, a dual-tasking paradigm, such as the Timed Up and Go-Dual Task (TUG-DT), may be useful in the diagnostic assessment of mild cognitive impairment (MCI). OBJECTIVE: To investigate the diagnostic and prognostic ability of a dual-tasking paradigm in patients with MCI or mild Alzheimer's disease (AD) and to evaluate the association between the dual-tasking paradigm and cerebrospinal fluid (CSF) AD biomarkers. METHODS: The study is a prospective cohort study conducted in a clinical setting in two memory clinics. Eighty-six patients were included (28 MCI, 17 AD, 41 healthy controls (HC)). The ability to perform dual-tasking was evaluated by the TUG-DT. Patients underwent a standardized diagnostic assessment and were evaluated to determine progression yearly. RESULTS: ROC curve analysis illustrated a high discriminative ability of the dual-tasking paradigm in separating MCI patients from HC (AUC: 0.78, AUC: 0.82) and a moderate discriminative ability in separating MCI from AD (AUC: 0.73, AUC: 0.55). Performance discriminated clearly between all groups (p CONCLUSION: In our study, we found that patients with MCI and mild AD have increasing difficulties in dual-tasking compared to healthy elderly. Hence, the dual-tasking paradigm may be a potential complement in the diagnostic assessment in a typical clinical setting. |
DOI | 10.3233/JAD-161310 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29278887 |