Title | Relationship of Area of Soft Drusen in Retina with Cerebral Amyloid-β Accumulation and Blood Amyloid-β Level in the Elderly. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Shoda, C, Kitagawa, Y, Shimada, H, Yuzawa, M, Tateno, A, Okubo, Y |
Journal | J Alzheimers Dis |
Volume | 62 |
Issue | 1 |
Pagination | 239-245 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Histopathological studies have confirmed that soft drusen contains amyloid-β (Aβ). OBJECTIVE: To examine the relationship between the area of soft drusen in the macular area and cerebral Aβ accumulation or plasma Aβ level in elderly persons without dementia. METHODS: Fourteen consecutive patients (18 eyes) aged ≥50 years with macular soft drusen were studied prospectively. From color fundus photographs, the area of soft drusen (pixel) within a 6,000 μm diameter with the macula as center was measured. Standard uptake value ratio (SUVR) was obtained from positron emission tomography using florbetapir, which indicates the ratio of cerebral cortical-to-cerebellar Aβ accumulation. Ratio of plasma Aβ1-42 to Aβ1-40 level was calculated. RESULTS: Mean age was 73.3±7.6 years. The soft drusen area was 4.32±2.42 mm2. The SUVR was 1.08±0.15. Plasma Aβ1-42/Aβ1-40 ratio was 0.17±0.08. When SUVR ≥1.10 was defined as positive and CONCLUSION: Among elderly persons without dementia, the area of soft drusen was larger in those with more extensive cerebral Aβ accumulation. The area of soft drusen may be a biomarker of cerebral Aβ accumulation. |
DOI | 10.3233/JAD-170956 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 29439351 |