Title | Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Sánchez-Benavides, G, Grau-Rivera, O, Cacciaglia, R, Suárez-Calvet, M, Falcon, C, Minguillon, C, Gramunt, N, Sala-Vila, A, Gispert, JDomingo, Molinuevo, JLuis |
Journal | J Alzheimers Dis |
Volume | 65 |
Issue | 1 |
Pagination | 181-191 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Subtle cognitive decline preceding cognitive impairment can be self-perceived, referred to as subjective cognitive decline (SCD), or go unrecognized. OBJECTIVE: To study the clinical, cognitive, and structural neuroimaging characteristics of psychometrically normal subjects without self-awareness of cognitive decline (unaware decliners, UD) and to compare them with SCD participants and controls. METHODS: 2,640 participants from the ALFA cohort, 1,899 controls, 173 UD (decline reported by the informant only), and 568 SCD underwent clinical and cognitive explorations. A subset of 530 underwent structural MRI (379 Controls; 43 UD; 108 SCD). Linear models adjusting for confounders (age, sex, education, and mood state) were used to assess group differences on cognition and voxel-wise grey matter (GM) volumes. RESULTS: 6.6% were UD while 21.5% SCD. No differences in anxiety and depression were observed between controls and UD, while SCD did (p CONCLUSIONS: UD had worse memory performance than controls which correlated with hippocampal GM volume and presented brain volume increments in self-appraisal areas (medial frontal and insula). Individuals unaware of cognitive decline may represent a distinct group at risk for cognitive impairment and support the usefulness of informant-reported cognitive decline. |
DOI | 10.3233/JAD-180378 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30010134 |
PubMed Central ID | PMC6087444 |