Title | Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Ramanan, VK, Przybelski, SA, Graff-Radford, J, Castillo, AM, Lowe, VJ, Mielke, MM, Roberts, RO, Reid, RI, Knopman, DS, Jack, CR, Petersen, RC, Vemuri, P |
Journal | J Alzheimers Dis |
Volume | 65 |
Issue | 4 |
Pagination | 1345-1352 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Statins have been proposed to reduce the risk of Alzheimer's disease (AD). OBJECTIVE: Assess whether long-term statin use was associated with neuroimaging biomarkers of aging and dementia. METHODS: Methods: We analyzed neuroimaging biomarkers in 1,160 individuals aged 65+ from the Mayo Clinic Study of Aging, a population-based prospective longitudinal study of cognitive aging. RESULTS: Statin-treated (5+ years of therapy) individuals had greater burden of mid-and late-life cardiovascular disease (p CONCLUSIONS: Long-term statin therapy was not associated with differences in AD biomarkers. Individuals with long-term statin exposure had worse white matter integrity in the genu of the corpus callosum, consistent with the coexistence of higher cerebrovascular risk factor burden in this group. |
DOI | 10.3233/JAD-180446 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30149450 |
PubMed Central ID | PMC6260813 |
Grant List | R01 AG041851 / AG / NIA NIH HHS / United States C06 RR018898 / RR / NCRR NIH HHS / United States R01 AG056366 / AG / NIA NIH HHS / United States R01 AG034676 / AG / NIA NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States R01 AG011378 / AG / NIA NIH HHS / United States R01 AG037551 / AG / NIA NIH HHS / United States R01 AG043392 / AG / NIA NIH HHS / United States R01 NS097495 / NS / NINDS NIH HHS / United States P50 AG044170 / AG / NIA NIH HHS / United States R01 AG049704 / AG / NIA NIH HHS / United States RF1 AG055151 / AG / NIA NIH HHS / United States U01 AG006786 / AG / NIA NIH HHS / United States |