Title | Gene Transfer Induced Hypercholesterolemia in Amyloid Mice. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Grames, MS, Dayton, RD, Lu, X, Schilke, RM, J Alexander, S, A Orr, W, Barmada, SJ, Woolard, MD, Klein, RL |
Journal | J Alzheimers Dis |
Volume | 65 |
Issue | 4 |
Pagination | 1079-1086 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | A risk factor for cardiovascular disease (CVD), mutant PCSK9, was expressed in APP/PS1 mice to study the CVD-Alzheimer's disease inter-relationship. Cholesterol levels were elevated by 5-6-fold from 3 to 13 weeks after PCSK9 gene transfer. We tested whether hypercholesterolemia would increase amyloid-β plaques at a relatively early stage of plaque deposition. Plaque burden was increased in the hippocampus of PCSK9 treated mice though the increase was modest compared to the large elevation in cholesterol. Elevating cholesterol via gene transfer could be valuable in a variety of disease models compared to making crosses with germ-line transgenic mouse models of CVD. |
DOI | 10.3233/JAD-180494 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30124449 |