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TitleEthical Issues in the Treatment of Late-Stage Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsWatt, AD, Jenkins, NL, McColl, G, Collins, S, Desmond, PM
JournalJ Alzheimers Dis
Volume68
Issue4
Pagination1311-1316
Date Published2019
ISSN1875-8908
Abstract

There is hope that the continuing efforts of researchers will yield a disease-modifying drug for Alzheimer's disease. Such a drug is likely to be capable of halting, or significantly slowing, the underlying pathological processes driving cognitive decline; however, it is unlikely to be capable of restoring brain function already lost through the pathological process. A therapy capable of halting Alzheimer's disease, while not providing restoration of function, may prompt serious ethical questions. For example, is there a stage in the disease process when it becomes too late for therapeutic intervention to commence? And who bears the responsibility of making such a decision? Conversations regarding the ethics of treating neurodegenerative conditions with non-restorative drugs have been largely absent within both clinical and research communities. Such discussions are urgently required to ensure that patients' rights and well-being are protected when such therapeutic options become available.

DOI10.3233/JAD-180865
Alternate JournalJ. Alzheimers Dis.
PubMed ID30475773
PubMed Central IDPMC6484269
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Source URL: https://www.j-alz.com/content/ethical-issues-treatment-late-stage-alzheimers-disease