The 2019 Alzheimer Award goes to Yan-Jiang Wang, MD, PhD and Xian-Le Bu, MD, PhD as co-authors of the winning JAD paper: "Gut Microbiota is Altered in Patients with Alzheimer's Disease." For more information, click the image or go to: j-alz.com/award
LATEST JAD EDITORS’ BLOG “Checkmate the Onset of Dementia”: Prescribing Chess to Elderly People as a Primary Prevention of Dementia by Ivan Fernández Vega, MD, PhD
Superior frontal gyrus was stained with Thio-S and SIRT3 double staining. Thio-S positive staining (green color) depicted amyloid plaques and neurofibrillary tangles strongly in AD cases, whereas SIRT3 staining (red color) was stronger in controls and weaker in AD. From Li et al., JAD69(2).
AAV8-GFP-p25 was injected via intracerebroventricular (i.c.v.) at 8 weeks old. One month later, AAV9-CIP-T2A-mCherry was i.c.v.injected. One week later, hippocampal slices were assessed. Green or red fluorescence indicated expression of fusion protein GFP-p25 or mCherry. From Xu et al., JAD70(2).
Our latest book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6
DBH-positive locus coeruleus (LC) fibers and the blood-brain barrier marker SMI71 in Tg344-19 AD rat cortex (left). Cortical albumin and SMI71 co-labeling in AD rats receiving a LC lesion (right) compared to control (center). From Kelly et al., JAD70(2).
Aggregated Aβ1-42 induced cellular tauopathy in primary cortical neurons. Pretreated the neurons with increasing concentrations of amylin had protective effects against the Aβ induced tauopathy in a dose-dependent, U shape pattern. From Gan et al., JAD70(4).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
TDP-43 (red) co-localized with a fraction of PKAcα and PKAcβ (green) in the nucleus of HeLa cells. From Gu et al., JAD70(4).
Treatment with a single intraperitoneal dose of scFV-h3D6 in young 3xTg-AD female mice decreases intracellular amyloid burden and preserves cell density. From Esquerda-Canals et al., JAD70(4).