The new issue of JAD (Vol.77, Iss.2) is currently openly available in honour of World Alzheimer's Day on Sep 21. We are promoting awareness of Alzheimer's ressearch throughout September and World Alzheimer's Month. View the free content at: bit.ly/JAD77-2
COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
Our latest book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI
The 2020 Alzheimer Award goes to Christin Nance, BA, and Sarah Banks, PhD, as co-authors of the winning JAD paper: "The Pathology of Rapid Cognitive Decline in Clinically Diagnosed AD." For more details, click the image or go to: j-alz.com/award
Expression of taste marker molecules in the circumvallate papillae of wild type and App knock-in mice. Plcβ2 (green) and Car4 (magenta) are type II and III taste cell markers, respectively. Scale bar is 50 μm. From Narukawa et al., JAD76(3).
LATEST JAD EDITORS’ BLOG Robots and Avatars that Show Emotions and the Role of Telepresence during the COVID-19 Pandemic by Elena Portacolone, Jodi Halpern, Jay Luxenberg, Krista L. Harrison, and Kenneth E. Covinsky
This figure depicts age-dependent upregulation of AβPP protein in astrocytes in Alzheimer’s transgenic 5XFAD mice. This study identified a new mechanism underlying age-dependent amyloid-β deposition in Alzheimer’s disease. From Liang and Raven et al., JAD76(3).
JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT
Immunofluorescence images of amyloid-β (red) and Pezo2 (marker of trigeminal mesencephalic nucleus (Vmes) neuron, green) in the rostral and caudal part of Vmes in 2-7-month-old 3×Tg-AD mice. Scale Bars =50 µm. From Goto et al., JAD 76(4).
Aβ peptides increase cerulean lifetime and reduces FRET between Cer-VAMP2 and Cit-SNAP25 in differentiated N2A cells. Spatial lifetime images and frequency histograms of (A) Cer-VAMP2 only; Cer-VAMP2 and Cit-SNAP25 in (B) control cells (C) +Aβ40; (D) +Aβ42. From Sharda et al., JAD77(1).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
This JAD special issue moves forward the field of "gait & cognition" in neurodegeneration and aging. The issue has been compiled by guest editors Manuel Montero-Odesso and George Perry. VIEW CONTENT
Widespread tau pathology develops after injection of AAV containing human truncated tau and mCherry. Neurons contain hyperphosphorylated tau (AT8+) in wild-type mice injected with AAV-hSyn-htTau, but not when injected with control AAV-hSyn-mCherry. From Vogels et al., JAD77(2).
Aβ plaque (blue) in the spinal cord of a 5xFAD transgenic AD mouse is surrounded by astrocytic processes (green) and dystrophic neprilysin-positive neurites (red). A neprilysin-expressing motorneuron is seen at the bottom right. From Chu et al., JAD77(3).