COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
Immunofluorescence images (anti-β-III-tubulin labelling: green color; nuclear DAPI staining: blue color) of neurodifferentiated cells treated with TA8Amino, an acetylcholinesterase inhibitor, compared with untreated cells. From Moreira et al., JAD78(1).
Our latest book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI
Worse MMSE and ADAS-cog total score were associated with temporo-parietal volume loss (by MRI) and hypoperfusion (by 123I-IMP SPECT) in AD, demonstrated by multiple regression analyses. MMSE, but not ADAS-cog, was associated with the posterior midline structures. From Hong et al., JAD78(4).
The 2020 Alzheimer Award goes to Christin Nance, BA, and Sarah Banks, PhD, as co-authors of the winning JAD paper: "The Pathology of Rapid Cognitive Decline in Clinically Diagnosed AD." For more details, click the image or go to: j-alz.com/award
Neural activation during item memory encoding assessed with functional MRI (left) and cerebral tau protein accumulation measured using PET with the tracer AV-1451 (right) in patients with mild Alzheimer’s disease. From Richter et al., JAD78(4).
LATEST JAD EDITORS’ BLOG Robots and Avatars that Show Emotions and the Role of Telepresence during the COVID-19 Pandemic by Elena Portacolone, Jodi Halpern, Jay Luxenberg, Krista L. Harrison, and Kenneth E. Covinsky
Anti-Aβ antibody Aducanumab regulates the proteome of senile plaques (SP) and closely surrounding tissue regions (SPP-L1 and SPP-L2) in tgAPPPS1-21 mice. Regions were isolated by laser microdissection and analyzed by state-of-the-art mass spectrometry analysis. From Bastrup et al., JAD79(1).
JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT
Individual fusion, MRI and [11C]-PiB images of a 49-year-old patient. Increased [11C]-PiB uptake is seen in cortical right prefrontal lobe (white arrows, Z-score value of 3.69). From Ylä-Herttuala et al., JAD79(1).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Neurofibrillary tangle and tufted astrocytes evidenced with different markers of the tau protein and counterstained with thiazine red dye in a PSP case. From Martínez-Maldonado et al., JAD 79(4).
This JAD special issue moves forward the field of "gait & cognition" in neurodegeneration and aging. The issue has been compiled by guest editors Manuel Montero-Odesso and George Perry. VIEW CONTENT