The 2020 Alzheimer Award goes to Christin Nance, BA, and Sarah Banks, PhD, as co-authors of the winning JAD paper: "The Pathology of Rapid Cognitive Decline in Clinically Diagnosed AD." For more details, click the image or go to: j-alz.com/award
Our latest book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI
COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
LATEST JAD EDITORS’ BLOG Robots and Avatars that Show Emotions and the Role of Telepresence during the COVID-19 Pandemic by Elena Portacolone, Jodi Halpern, Jay Luxenberg, Krista L. Harrison, and Kenneth E. Covinsky
Patients with COVID-19 may have a wide range of neurological manifestation as the SARS-Cov2 virus can affect the nervous system in many different ways. From Fotuhi et al., JAD76(1).
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
P. gingivalis attaches to neurons (A, B, C), is internalized (C, D, E), and is associated with disruption of the cytoskeleton (E). From Haditsch et al., JAD75(4).
JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT
[18F]PM-PBB3 tau PET showed slightly diffuse tracer binding in cerebral lobes, especially in the left frontal cortex overlapping with the hypometabolic area in FDG PET in a patient with frontotemporal dementia of P301L MAPT mutation. Su and Fu et al., JAD76(1).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Confocal microscopy images of circumvallate papilla taste buds from APP/PS1 and control mice demonstrating expression of TRPM5 (a marker of sweet, bitter, and umami TRCs, green) and Car4 (expressed in sour TRCs, blue). From Wood et al., JAD76(2).
Expression of taste marker molecules in the circumvallate papillae of wild type and App knock-in mice. Plcβ2 (green) and Car4 (magenta) are type II and III taste cell markers, respectively. Scale bar is 50 μm. From Narukawa et al., JAD76(3).
This JAD special issue moves forward the field of "gait & cognition" in neurodegeneration and aging. The issue has been compiled by guest editors Manuel Montero-Odesso and George Perry. VIEW CONTENT
This figure depicts age-dependent upregulation of AβPP protein in astrocytes in Alzheimer’s transgenic 5XFAD mice. This study identified a new mechanism underlying age-dependent amyloid-β deposition in Alzheimer’s disease. From Liang and Raven et al., JAD76(3).