LATEST JAD EDITORS’ BLOG
What is Aβ?
by Sally Hunter
The Journal of Alzheimer's Disease
celebrates its 20th anniversary in 2018. The special open access celebratory issue (Vol. 62, Iss.3) features 35 review articles covering 20 years of Alzheimer's disease research, plus personal perspectives from researchers in the field.
DCX-EGFP-expressing cells from mice transfected with DCX-ChR2-EGFP lentiviruses experienced the period of type-2b IPs, type-3 IPs, immature neurons and migrating immature neurons (red arrowhead) during adult neurogenesis in hippocampus after traumatic brain injury. From Zhao et al., JAD63(1).
Primary hippocampal neurons were stained with phalloidin (green) to evidence the actin cytoskeleton and with DAPI (blue) to identify nuclei morphology. Different diterpenes reduced the frequency of apoptotic nuclei induced by 1µM Aβ challenge. From Zolezzi et al., JAD63(2).
A rat model of entorhinal tau accumulation using the viral-mediated transfer of mutant tau gene. Hyperphosphorylated tau (red) aggregated in cells in the entorhinal cortex following the injection of rAAV vectors with P301L tau, but not GFP (green). From Nouriziabari et al., JAD63(2).
JAD Reports is a new international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
Hydroxytyrosol administration reduces TNF-α (red) expression within GFAP-positive (green) astrocytes in the hippocampus of TgCRND8 mice. Nardiello et al., JAD63(3).
Transgenic overexpression of human Pyk2, a novel AD risk factor, causes enhanced tyrosine phosphorylation of tau in P301L tau transgenic mice (left). In vitro validation of Pyk2 as a tau tyrosine kinase (right). From Li and Götz, JAD64(1).
M2 muscarinic receptors (A1-B1) are distributed in presynaptic GABAergic terminals (B2-B4) making contact with glutamatergic postsynaptic pyramidal neurons (A2-A4) in the CA1 field of the hippocampus of 3xTg-AD mice. From Llorente-Ovejero et al., JAD64(1).