JAD71:s1 Gait DisordersIRNDPJAD70:s1 IRNDPJAD CMEBook and manPARK2AbetaAIAD VOl.6TDP-433xTg-ADJAD ReportsSH-SY5YVenus-Tau-Teal2019 Alzheimer Award

All content in JAD's new special issue on Gait Disorders is openly available through September (#WorldAlzMonth) and October. We invite you to share the content to spread awareness of the latest AD research. VIEW CONTENT

LATEST JAD EDITORS’ BLOG
The Next Generation of Evidence for Dementia Risk Reduction
by Ruth Peters and Kaarin Anstey

JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT

Now available: JAD CME! Fully ACCME accredited for US & Canadian physicians, this series of CME articles launches with 10 JAD articles plus corresponding post-tests (1.0 AMA PRA Category 1 Credit™ each). In partnership with the ACEA. LEARN MORE

Journal of Alzheimer's Disease

is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.

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A cell model of Alzheimer’s disease based on Tau and APP overexpression diminishes mitochondrial PARK2 targeting and causes damaged mitochondria accumulation labeled by PINK1 demonstrating a mitophagy failure. From Martín-Maestro et al., JAD70(2).

Aggregated Aβ1-42 induced cellular tauopathy in primary cortical neurons. Pretreated the neurons with increasing concentrations of amylin had protective effects against the Aβ induced tauopathy in a dose-dependent, U shape pattern. From Gan et al., JAD70(4).

Our latest book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6

TDP-43 (red) co-localized with a fraction of PKAcα and PKAcβ (green) in the nucleus of HeLa cells. From Gu et al., JAD70(4).

Treatment with a single intraperitoneal dose of scFV-h3D6 in young 3xTg-AD female mice decreases intracellular amyloid burden and preserves cell density. From Esquerda-Canals et al., JAD70(4).

JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content

Distribution of Aβ42 in cell cultures after 24h incubation. SH-SY5Y cells after differentiation with various agents. From Krishtal et al., JAD71(3).

Primary mouse cortical neurons expressing Venus-Tau-Teal, a biosensor for tau unfolding, were treated with amyloid-β (Aβ) oligomers or vehicle for 6 hours, and then were visualized by 2-photon fluorescence lifetime imaging. From Rudenko et al., JAD 71(4).

The 2019 Alzheimer Award goes to Yan-Jiang Wang, MD, PhD and Xian-Le Bu, MD, PhD as co-authors of the winning JAD paper: "Gut Microbiota is Altered in Patients with Alzheimer's Disease." For more information, click the image or go to: j-alz.com/award 

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