AIAD Vol.8Jack de la Torre blogCOVID-19 contentdentateBook and manNCCRAIAD Vol.7 (TBI)Appmice2020 Alzheimer AwardICCmapsJAD70:s1 IRNDPcognitivedeclineJAD Reports (updated)STED

This new book, edited by Lilian Calderón-Garcidueñas, is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. For details & to order, click the image or go here

What is the Purpose of Medicine When Dealing with Incurable Alzheimer’s Disease?

by Jack de la Torre, MD, PhD

COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via:

Neuroinflammation markers in the hippocampal dentate gyrus of rats, 14 days after intracerebroventricular injection of Aβ42 peptide (right), or vehicle (left). Astrocytes stained with GFAP (green), microglia with Iba1 (red), and nuclei with DAPI (blue). From Paulo et al., JAD82(3).

Journal of Alzheimer's Disease

is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.


Neuronal cell cycle re-entry (NCCR) in AppNLF KI mice enhances neuroinflammation as demonstrated by CD45 (red) staining with and without Iba1 (green), showing increase in activated microglia and brain leukocyte infiltration (*) at various ages. From Barrett et al., 82(4).

This book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: 

Loss of noradrenergic afferents is observed in the neocortex and hippocampal CA1 subfield in 24-month-old AppNL-G-F/NL-G-F mice. Brain sections were immunostained with anti-norepinephrine transporter (green) and anti-amyloid-β (magenta). From Sakakibara et al., JAD82(4).

The 2020 Alzheimer Award goes to Christin Nance, BA, and Sarah Banks, PhD, as co-authors of the winning JAD paper: "The Pathology of Rapid Cognitive Decline in Clinically Diagnosed AD." For more details, click the image or go to: 

Voxel-wise ICC maps show that the reproducibility of longitudinal gray matter volume changes determined by VBM between non-accelerated and accelerated MRI is good to excellent for many regions but may vary between diseases and regions. From Takao et al., JAD83(1).

JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT

First signs of cognitive decline in Alzheimer's disease can be attributed to bilateral posterior ventrolateral thalamic (purple) and pallidal (blue) grey matter loss (red) in a large sample of individuals with early mild cognitive impairment. From van de Mortel, JAD83(2).

JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content

3D, 3-channel STED microscopy was performed to visualize amyloid precursor protein fragments in early endosomes in hippocampal neurons. A schematics summarizing how an early endosome sorts APP-CTF and APP-NTF into different vesicles is shown to the right. Yu et al., JAD83(2).

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