celebrates its 20th anniversary in 2018. The international multidisciplinary journal facilitates progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
LATEST JAD EDITORS’ BLOG Alzheimer’s Disease Research: A Modern Version of the Parable of the Blind Men and an Elephant by Shi-Jiang Li, PhD
SIRT1 co-localizes well with SC35 in HeLa nucleus. The cells were immunostained by anti-HA or anti-Myc and followed by TRITC-anti-rabbit IgG or FITC-anti-mouse IgG. Hoechst was used for the staining of nuclei. From Yin et al., JAD61(2).
Akt phosphorylation deficit (pAkt473, red) in discrete cortical neuronal compartments (arrows) in response to amyloidogenic APP processing (green). APP processing monitored via APP GAL4 carrying the Swedish mutation coupled to a UAS-GFP reporter. From Law et al., JAD61(2).
Immunofluorescence labeling of GFAP (green), APOE4 (red), and merged image (C) showing their co-localization in AD brain. From Thangavel et al., JAD61(2).
JAD Reports is a new international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
Confirming in vivo visualization of tau pathology and neuroinflammation. PBB3 labeled AT8-positive neuronal inclusions in the rTg4510 mouse (upper panels). This mouse model expressed TSPO protein in activated microglia (lower panels). From Ishikawa et al., JAD61(3).
Immunofluorescence staining of the Chinese tree shrew cortex tissue shows an age-dependent increase of total Aβ and a co-localization of total Aβ with neurofilament-H protein in neurons. From Fan et al., JAD61(3).
Human brain sections were stained with the microglial marker Iba1 (green) and TREM2 (red). Iba1 positive ramified microglia were seen in normal healthy brain that did not colocalised with TREM2 positive neurons. From Raha-Chowdhury et al., JAD61(3).
The 2017 Alzheimer Award goes to Shi-Jiang Li for "Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers". For more information, click here or go to www.j-alz.com/award.
Immunofluorescence stainings showing intra- and extracellular deposits of endogenous Aβ (red; left, middle) in the aged mouse brain; α-synuclein (Syn, green) did not aggregate into Lewy body-like structures (right); Lip, lipofuscin. From Ahlemeyer et al., JAD61(4).
Neurons, microglia and astrocytes were stained by NeuN, Iba1 and GFAP. Colocalization of HDAC3 (green) and NeuN/Iba1/GFAP (red) in the hippocampi of wild-type C57BL/6 mice was shown. The expression of HDAC3 was detected mainly in neurons of hippocampi. Yu et al., JAD61(4).
Immunostaining of SFPQ and Tau in human brains with AD. Cells with different SFPQ dislocation type and DAPI type were picked out and magnified in right panel. From Lu et al., JAD61(4).