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LATEST JAD EDITORS’ BLOG
What is Aβ?
by Sally Hunter

Immunostaining of SFPQ and Tau in human brains with AD. Cells with different SFPQ dislocation type and DAPI type were picked out and magnified in right panel. From Lu et al., JAD61(4).

Distribution of Aβ deposits in APPswe/PS1dE9 mice throughout the different layers in the OB (A). 6m and 24m old mice (B,C). Anti-Aβ in green and DAPI in blue. Bars, 50 µm. t-test number and % area of Aβ deposits in OB (D,E). ***p>0.001. From Reale et al., JAD62(1).

Immunostaining for BRCA1(Ser1524) (Red) and presenilin 1 (Green) in Alzheimer's disease and control NES cells (A) and neurons (B). Nuclei were stained with DAPI (blue). BRCA1-PS1 colocalization was assessed by Mander’s factor. From Wezyk et al., JAD62(1).

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Primary cortical neurons were stained with MAP-2 (red) and nuclei were stained with DAPI (blue). Sulforaphane reduces natural Aβ oligomer-induced neurotoxicity in primary cortical neuron cultures. From Hou et al., JAD 62(4).

Abnormal hyperphosphorylation of Rab10 (pRab10-T73, red) in dystrophic neurites around amyloid plaques (6E10, green) in the human Alzheimer’s disease brain (Scale bar: 20µm). Rab10 phosphorylation is a prominent pathological feature in Alzheimer’s disease. From Yan et al., JAD63(1).

DCX-EGFP-expressing cells from mice transfected with DCX-ChR2-EGFP lentiviruses experienced the period of type-2b IPs, type-3 IPs, immature neurons and migrating immature neurons (red arrowhead) during adult neurogenesis in hippocampus after traumatic brain injury. From Zhao et al., JAD63(1).