VE-cad signals (arrowheads) in brain frontal cortex areas from AD patients and normal controls. Nuclei were counterstained with DAPI (blue). Normal rabbit IgGs were utilized as negative controls to demonstrate background fluorescence (white squares). From Bei et al., JAD95(3).
The 2023 Alzheimer's Award goes to Henning Tiemeier, MD, PhD, and Rosanne Freak-Poli, PhD, as co-authors of this winning paper, which presents important insights into the impact of poor social health, specifically loneliness, on cognitive decline and the risk of dementia in older adults.
Six spatiotemporal perfusion circuits were identified based on the differences in the arterial transit time values for 12 neuropsychiatric sub-symptoms in patients with Alzheimer's disease performed the pseudo-continuous arterial spin labeling among brain regions. From Jiang et al., JAD95(3).
Edited by Giulio M. Pasinetti, this book (AIAD Vol.9) is a compilation of work by researchers intent on exploring the complex role of the gut microbiome in Alzheimer’s disease.
The expression of pRhoA at S188 in the hippocampus and cortex is dependent on the stereotactic plane. pRhoA expression decreased in the rostral regions (Plane 2) but increased in the caudal regions corresponding to Plane 4. From Nik Akhtar and Lu, JAD 95(4).
COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
Exploring the association between posttraumatic stress disorder, traumatic brain injury, and vulnerability to Alzheimer's disease. Manual tractography was applied in male veterans to investigate the white matter microstructure of three fiber tracts. From Marcolini et al., JAD95(4).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Patients with AD were divided into two groups based on a 130 g/day net carbohydrate (nCHO) cutoff. Results comparing lower-higher nCHO groups suggest that restricting carbohydrates may reduce atrophy in sensorimotor and visual cortex. From Bramen et al., JAD96(1).
Tau PET tracer retention quantified as standardized uptake ratio (SUVR) was elevated in the limbic and neocortical areas of AD patients and was further increased in the pons, including the locus coeruleus, of the patients with marked tooth loss (arrowhead). From Matsumoto et al., JAD96(3).