Our new book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6
The Journal of Alzheimer's Disease
celebrates its 20th anniversary in 2018. The special open access celebratory issue (Vol. 62, Iss.3) features 35 review articles covering 20 years of Alzheimer's disease research, plus personal perspectives from researchers in the field.
Insulin delivery to the brain using islet transplantation into cranial subarachnoid cavity. A) HRP insulin staining. B) IF insulin (red), alpha-SMA (green) and nuclei (blue) staining. From Bloch et al., JAD65(4).
In SH-SY5Y cells, Tau-induced Ring-shaped Microtubule bundles (RsMtb) (arrows) are resistant to either Taxol (A) or Nocodazole (B) treatments. In panel B, lateral strands of Microtubules (arrowheads) are projecting from RsMtb (arrows). From Rodríguez-Cruz et al., JAD65(4).
Confocal images showing amyloid-β (Aβ) internalization in rat primary astrocytes (green) and its colocalization (yellow) with GFAP (red). Discrete vesicular-like structures stained with Aβ40 were observed inside the cell but not with Aβ42. From Domínguez-Prieto et al., JAD65(4).
APPSwe/Lon knock-in mice (PLB2APP) display heightened hippocampal astrogliosis at 6 months compared to PLBWT controls, correlating with the onset of cognitive phenotypes. Green-astrocytes (GFAP), red-neuronal bodies (αNeuN), blue-nuclei (DAPI). From Plucińska et al., JAD65(1).
Recruited bone marrow-derived microglia are in close proximity to amyloid depositions. From Steffen et al., JAD65(2).
The 2018 Alzheimer Award goes to Greg Kennedy as the author of the winning JAD paper: "How Does Excercise Reguce the Rate of Age-Associated Cognitive Decline? A review of potential mechanisms." For more information, click the image or go to: j-alz.com/award
Confocal microscope images show that HO-1 (red) induces Tau-oligomer (green) formation and co-localizes with Tau-oligomer in the hippocampal CA3 region of HO-1 transgenic mice. From Si et al., JAD65(2).
JAD Reports is a new international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
LATEST JAD EDITORS’ BLOG What is Aβ? by Sally Hunter
SOX1 protein expression (green) in immature (DCX+) granule cells (red) of the hippocampus in non-transgenic mice. Yellow arrowheads marks cells immunopositive for both proteins. From Zaletel et al., JAD65(3).