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LATEST JAD EDITORS’ BLOG
What is Aβ?
by Sally Hunter

In hippocampus of a mouse model of Alzheimer’s disease receiving transplantation with bone-marrow-derived microglia-like (BMDML) cells, BMDML cells were co-localized with Aβ (arrows). Z-stack image clearly indicates Aβ phagocytosis by BMDML cells. From Kawanishi et al., JAD64(2).

Plaques of patients with Alzheimer’s disease can be visualized with both Methoxy-X04 staining (blue) and antibodies against hyperphosphorylated tau protein (PHF-Tau) isoforms, as PHF-Tau-pS396 (green) and PHF-Tau-AT8 (red). From Furcila et al., JAD64(2).

QSM and Aβ-PET in fusion with T1-weighted MRI of a Alzheimer’s disease (AD) patient and a healthy control (HC) showing higher susceptibility for AD patient in globus pallidus, but not in cortical areas despite a higher PET signal. From Tiepolt et al., JAD64(2).

JAD Reports is a new international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.

Translocated I2PP2A/SET (green) is colocalized with hyperphosphorylated tau (red) in the neuronal (nuclei, blue, TOPRO) cytoplasm in cerebral cortex of 3xTg-AD mice with traumatic brain injury. From Hu et al., JAD64(3).

In temporal cortex tissue from a representative Alzheimer’s disease patient, the receptor for advanced glycation endproducts (RAGE) is highly expressed in IBA1-expressing myeloid cells. Code: RAGE, green; IBA1, red; DAPI, blue; and far right panel (yellow), merge. From Derk et al., JAD 64(3).

SiRNA technique has been used to decrease ABCA7 expression in murine endothelial cells reproducing the blood-brain barrier in vitro. ABCA7 deficiency does not disrupt expression and localisation of tight junction proteins. From Lamartinière et al., JAD64(4).