LATEST JAD EDITORS’ BLOG
Alzheimer’s Disease, the Sweet Trail to Neuroprotection
by Stefano Sensi, MD, PhD
Our new book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6
The Journal of Alzheimer's Disease
celebrates its 20th anniversary in 2018. The special open access celebratory issue (Vol. 62, Iss.3) features 35 review articles covering 20 years of Alzheimer's disease research, plus personal perspectives from researchers in the field.
Insulin delivery to the brain using islet transplantation into cranial subarachnoid cavity. A) HRP insulin staining. B) IF insulin (red), alpha-SMA (green) and nuclei (blue) staining. From Bloch et al., JAD65(4).
In SH-SY5Y cells, Tau-induced Ring-shaped Microtubule bundles (RsMtb) (arrows) are resistant to either Taxol (A) or Nocodazole (B) treatments. In panel B, lateral strands of Microtubules (arrowheads) are projecting from RsMtb (arrows). From Rodríguez-Cruz et al., JAD65(4).
The 2018 Alzheimer Award goes to Greg Kennedy as the author of the winning JAD paper: "How Does Excercise Reguce the Rate of Age-Associated Cognitive Decline? A review of potential mechanisms." For more information, click the image or go to: j-alz.com/award
Confocal images showing amyloid-β (Aβ) internalization in rat primary astrocytes (green) and its colocalization (yellow) with GFAP (red). Discrete vesicular-like structures stained with Aβ40 were observed inside the cell but not with Aβ42. From Domínguez-Prieto et al., JAD65(4).
Co-immunofluorescent staining show that intracerebroventricular infusion of aged Aβ42 in mouse remarkably increases pS133-CREB immunoreactivity in microglia with reduced neuronal immunoreactivity at 24 h. From Gao et al., JAD66(1).
JAD Reports is a new international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
Confocal microscope images of the immunohistochemical analysis revel that meprin β (red) is co-localized with pGlu-Aβ containing plaques (blue) which are associated with astrocytes (green). From Schlenzig et al., JAD 66(1).
HSPA6 (Hsp70B`, red) is induced by MG132 proteotoxicity in differentiated human neuronal SH-SY5Y cells and targets the periphery of cytoplasmic protein aggregates (orange plus white star), confirmed by line scan and 3D analysis. (Blue = nuclear DNA). From Deane and Brown, JAD66(3).