Upcoming Supplementary Issue: Pro-oxidants and Antioxidants in Alzheimer’s Disease (Guest Editor: Pravat Mandal). Click the visual for details in the Calls for Papers (PDF) (opens in a new tab). The submission deadline: November 30, 2022.
NEW BOOK: Available for a limited time at a discount
Edited by Giulio M. Pasinetti, this book (AIAD Vol.9) is a compilation of work by researchers intent on exploring the complex role of the gut microbiome in Alzheimer’s disease. For details & to order, click the image or go here
Evidence for ApoE/Reelin-ApoER2 axis disruption in the entorhinal-hippocampal memory system in AD. ApoE, HNE-ApoE, Reelin, ApoER2, Dab1, and p-Tau accumulate in neuritic plaques in the molecular layers of the dentate gyrus (A-C) and cornu ammonis (D-F). From Ramsden et al., JAD87(3).
Upcoming Supplementary Issue: Novel Molecular Pathways and Therapeutic Challenges in Neurodegenerative Diseases (Guest Editors: Jagannatha Rao, et al.). Click the visual for details in the Calls for Papers (PDF) (opens in a new tab). The submission deadline: December 31, 2022.
pTau protein, detected through anti-S396, was found accumulating within cells from the hippocampus in very young rTg4510 mice (A – F). pTau at sites labeled by AT180 was found coexisting with neurons from cortex (G) and hippocampus (H and H’). From Xolalpa-Cueva et al., JAD87(2).
The 2022 Alzheimer Award goes to Yonas E. Geda, MD, and Janina Krell-Roesch, PhD, as co-authors of the winning JAD paper that presents important findings on the impact of physical activity on cognitive change in older adults. For details, go to: j-alz.com/award
A gut neuroepithelial circuit activation (the neuropod cells) in response to bacterial curli breach in the symptomatic AD mice. TLR2, Toll-Like Receptor 2; Aβ, amyloid-beta; PGP 9.5, Protein gene product 9.5 (neuroendocrine marker). From Das et al., JAD 88(1).
COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
Amyloid-β deposition in the olfactory pathway of WT and App-KI mice: olfactory bulb (OB), anterior olfactory nucleus (AOL), olfactory tubercle (OT), piriform cortex (PC), amygdala (Amg), and entorhinal cortex (EC). From Narukawa et al., JAD88(1).
LATEST JAD EDITORS’ BLOG
Familiar Music May Help Caregivers and Loved Ones Living with Dementia to Connect with One Another
by Aaron Colverson
This new book, edited by Lilian Calderón-Garcidueñas, is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. For details & to order, click the image or go here
G) A compact plaque double stained with anti-Aβ antibody W02 (red) and DAPI with 0.3% Sudan Black pretreatment to remove autofluorescence. H) The compact Aβ (arrows) remains DAPI-positive despite pretreatment, showing that DAPI stains compact plaques. From Mabrouk et al., JAD88(3).
This book, edited by Rudy J. Castellani covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI
Quiescent HSV-1 is reactivated by VZV infection to cause AD. (A) VCV-induced quiescence of HSV-1 shown by expression of LAT. VZV infection after HSV-1 latency confirmed by qPCR. HSV and VZV (B) and Aβ and TUJ1 expression (C) detected via immunostaining. From Cairns et al., JAD88(3).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.