LATEST JAD EDITORS’ BLOG “Checkmate the Onset of Dementia”: Prescribing Chess to Elderly People as a Primary Prevention of Dementia by Ivan Fernández Vega, MD, PhD
In neuronal cells, 24-h exposure to conditioned medium from activated BV2 microglia decreased lipid droplets. The figure shows fluorescence images of SH-SY5Y cells stained with BODIPY 493/503 and Hoeschst. From Ji et al., JAD67(3).
Early Onset AD with frontotemporal hypometabolism and dysexecutive impairment. 18F-FDG PET (a-e) shows marked frontal and temporal hypometabolism; 18F-Flutemetamol scan (f-j) shows diffused uptake of the amyloid tracer. From Gallucci et al., JAD67(3).
Our latest book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6
The 2018 Alzheimer Award goes to Greg Kennedy as the author of the winning JAD paper: "How Does Excercise Reguce the Rate of Age-Associated Cognitive Decline? A review of potential mechanisms." For more information, click the image or go to: j-alz.com/award
Paclitaxel blocks repeated mild brain injury (rmTBI)-induced loss of postsynaptic density-95 immunoreactivity in hippocampus. PSD-95 (green) expression was reduced in mice with rmTBI compared to sham or rmTBI with paclitaxel-treatment. From Cross et al., JAD67(3).
Representative images display higher expression and co-localization of Aβ (green), TXNIP (red), XNIP (green) and p-tau ser262 (red) in AD compared to non-AD brains. Boxed area shows the enlarged view of co-localization of TXNIP with Aβ and p-tau. From Li et al., JAD68(1).
Analysis of hippocampus from AD patients reveal the presence of alpha amylase (AMY2A in red) in glial cells adjacent to amyloid beta (6E10 in green) plaques. The AMY2A positive glial cells were identified as activated astrocytes (GFAP in green). From Byman et al., JAD68(1).
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Triple immunofluorescent images for Iba1 (red), CD14 (green) and FSB (blue) in the cortex of APPswe/PS1dE9 mice at 6 and 18 months of age. The mean percentage of CD14-positive microglia per total microglia in each Aβ plaque increased with age. From Fujikura et al., JAD68(1).
(A) Cerebral white matter degeneration, (B) hippocampal atrophy, (C) increased uptake of PiB, (D) normal brain MRI at early stage, (E) mild hypermetabolism of FDG, (F,G) increased uptake of PiB and AV45, (H) reduced dopamine transporter, (I) slight hippocampal atrophy. From Liu et al., JAD68(2).
Analysis of cortical tissue from AD patients reveals the presence of SPARC (in green) in and around glial cells within amyloid (ThioS in blue) plaques. These SPARC-associated glial cells were identified as microglia (IBA-1 in HRP brown). From Strunz et al., JAD68(2).