LATEST JAD EDITORS’ BLOG
Recent Advances in the Field of 3D Modelling for Neurodegeneration
by Silvia Bolognin
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
Our latest book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6
Confocal microscope images of the immunohistochemical analysis revel that meprin β (red) is co-localized with pGlu-Aβ containing plaques (blue) which are associated with astrocytes (green). From Schlenzig et al., JAD 66(1).
HSPA6 (Hsp70B`, red) is induced by MG132 proteotoxicity in differentiated human neuronal SH-SY5Y cells and targets the periphery of cytoplasmic protein aggregates (orange plus white star), confirmed by line scan and 3D analysis. (Blue = nuclear DNA). From Deane and Brown, JAD66(3).
The 2018 Alzheimer Award goes to Greg Kennedy as the author of the winning JAD paper: "How Does Excercise Reguce the Rate of Age-Associated Cognitive Decline? A review of potential mechanisms." For more information, click the image or go to: j-alz.com/award
SIRT-1 protein levels in nucleus of astrocytes is higher in 3xTgAD female than WT mice. Ingestion of bioactive food during 7 months reduced SIRT-1 levels in stratum radiatum. From Syeda et al., JAD66(4).
In vitro analysis of embryonic body differentiation revealed that induced pluripotent stem cells can differentiate into the three germ layers, i.e., the ectoderm (TUJ-1, green), mesoderm (SMA, red), and endoderm (AFP, green). From Xu et al., JAD 67(1).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Representative immunofluorescence staining in high AD specimen demonstrates that NeuN positive neuronal cells (G1, G2, green) express HAS2 (F1, F2, red). Nuclei in F1–G2 are stained with DAPI (blue). From Reed et al., JAD67(1).
Neurite outgrowth images of Aβ-GFP SH-SY5Y cells with APOE/TRKA gene silence. APOE/TRKA gene silence reduced the NC009-1-promoted neurite outgrowth. TUBB3-positive cells and neurites were shown in yellow. Nuclei were counterstained with DAPI (blue). From Chen et al., JAD67(2).