Primary mouse cortical neurons expressing Venus-Tau-Teal, a biosensor for tau unfolding, were treated with amyloid-β (Aβ) oligomers or vehicle for 6 hours, and then were visualized by 2-photon fluorescence lifetime imaging. From Rudenko et al., JAD 71(4).
To clarify the cellular processes that may link TBI to AD development, we investigated the chronic impact of two injury models in tg-ArcSwe mice. Immunostainings revealed increased GFAP-expression (green) and Aβ deposition (red) 24 weeks post-injury. From Zyśk et al., JAD 72(1).
Now available: JAD CME! Fully ACCME accredited for US & Canadian physicians, this series of CME articles launches with 10 JAD articles plus corresponding post-tests (1.0 AMA PRA Category 1 Credit™ each). In partnership with the ACEA. LEARN MORE
Fluorescent immunostaining of hippocampal sections of TgAPP mice were injected with lentiviral (lv) plasmids showing USP13 knockdown increases p-tau ubiquitination (F) and reduces p-tau level (C) compared to mock (A,D) and USP13 overexpression (B,E). Liu et al., JAD72(2).
APP770, CatB, Aβ1-42 and Aβ3-42 (green) co-localized with macrophages (CD11b positive, red) in the gingival tissues of chronic periodontitis patients. From Nie & Wu et al., JAD72(2).
JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT
Snowball aggregation of mOC78 Aβ in 11-month-old 3xTgAD neurons. Brewer et al, JAD73(1).
LDLr-/- mice presented high levels of caspase-3 in hippocampus. In these animals, activated caspase 3 and neuronal marker signals were co-localized, suggesting increased neuronal death. From de Oliveira et al., JAD73(2).
Our latest book looks to the future of AD research. The editors comment: "Now is the most exciting period of a generation in our field, as old dogma makes way for new insight." For details & to order, click the image or go to: tiny.cc/AIAD6
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Differentiation of neural stem cells directly reprogrammed from the elderly sporadic Alzheimer’s disease dermal fibroblasts into neurons (A), astrocytes (B), and oligodendrocytes (C) as indicated by neural cell marker stainings after differentiation. From Liu and Wang, JAD73(3).
The 2019 Alzheimer Award goes to Yan-Jiang Wang, MD, PhD and Xian-Le Bu, MD, PhD as co-authors of the winning JAD paper: "Gut Microbiota is Altered in Patients with Alzheimer's Disease." For more information, click the image or go to: j-alz.com/award