COVID-19 content in JAD is openly available. Read all content including the editorial by JAD's Editor-in-Chief George Perry, in which he calls out for careful study to determine the numbers of AD patients infected and dying of COVID-19, via: bit.ly/JAD-COVID19
LATEST JAD EDITORS’ BLOG "Something in the Air": Air Pollution and Dementia Risk by Michael Hornberger, PhD
Anti-Aβ antibody Aducanumab regulates the proteome of senile plaques (SP) and closely surrounding tissue regions (SPP-L1 and SPP-L2) in tgAPPPS1-21 mice. Regions were isolated by laser microdissection and analyzed by mass spectrometry analysis. From Bastrup et al., JAD79(1).
Journal of Alzheimer's Disease
is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.
Individual fusion, MRI and [11C]-PiB images of a 49-year-old patient. Increased [11C]-PiB uptake is seen in cortical right prefrontal lobe (white arrows, Z-score value of 3.69). From Ylä-Herttuala et al., JAD79(1).
Our latest book, edited by Rudy J. Castellani, covers the relationship between neurodegenerative disease and neurotrauma through traumatic brain injury, and offers targets for therapy. For details & to order, click the image or go to: bit.ly/AIAD7-TBI
Neurofibrillary tangle and tufted astrocytes evidenced with different markers of the tau protein and counterstained with thiazine red dye in a PSP case. From Martínez-Maldonado et al., JAD 79(4).
The 2020 Alzheimer Award goes to Christin Nance, BA, and Sarah Banks, PhD, as co-authors of the winning JAD paper: "The Pathology of Rapid Cognitive Decline in Clinically Diagnosed AD." For more details, click the image or go to: j-alz.com/award
Brain tissues from 5xFAD mice model of Alzheimer’s disease showed that CBD treatment was able to increase the expression of IL-33 (red) in brain, mainly by astrocytes (green). From Khodadadi et al., JAD80(3).
JAD's open access IRNDP special issue features research from around the globe examining the potential risk factors for dementia. The issue has been compiled by guest editors Kaarin Anstey and Ruth Peters. VIEW CONTENT
Aβ plaques formation and microglia activation following different age in APP/PS1 mice and wild-type littermates. From Qiu et al., JAD81(2).
JAD Reports is our fully open access international, multidisciplinary journal dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease. View new content
Immunohistochemical co-localization of GABA transporter 1 (GAT1) and activated astrocytes (GFAP) in suprachiasmatic nucleus of 18 month old wild type and transgenic (TG) mouse model of AD. From Eeza et al., JAD81(2).
This JAD special issue moves forward the field of "gait & cognition" in neurodegeneration and aging. The issue has been compiled by guest editors Manuel Montero-Odesso and George Perry. VIEW CONTENT