24 May 2023
Case Study Reveals Potentially Lethal Side Effects of Lecanemab for Treatment of Alzheimer's Disease
In a noteworthy case study published in the Journal of Alzheimer’s Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer’s disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab. Four days after the last infusion, she experienced stroke symptoms and died several days later due to multifocal intracerebral hemorrhage despite attempts at therapeutic intervention. Neuropathologic findings reflected therapy-induced Aβ phagocytosis involving fibrillar Aβ both in the parenchymal brain tissue and in the cerebral vasculature.
13 May 2023
Air Pollution May Increase Risk of Dementia, Complicated by Genetics
Writing in the May 2, 2023 issue of the Journal of Alzheimer’s Disease, a team of researchers, led by scientists at University of California San Diego, further elaborate on how exposure to ambient air pollution, such as car exhaust and power plant emissions, is associated with a measurably greater risk of developing dementia over time.
26 April 2023
The beneficial effects of music on memory may depend on how it is listened to
The initial results of the study of the 'Mozart effect' on neurodegeneration show that listening to classical music in the background has no benefits for learning. The research has been carried out with people experiencing mild cognitive impairment, and it did find individual differences when listening to 'high-arousal' music.
4 April 2023
Depression and the Absence of a Stable Partner Can Accelerate Alzheimer’s Disease in People with Genetic Risk
Depressive symptoms and the absence of a stable partner can accelerate the progression of Alzheimer's disease in people who carry a genetic mutation. In addition, adequate treatment and controls in people with thyroid problems help delay depressive symptoms, progression to dementia, and death. These findings were reached by a team of researchers from the Universidad de Antioquia, Colombia, Universidad Nacional de Colombia, and Hamburg-Eppendorf University Medical Center, Germany, in a population with the "paisa mutation" or presenilin 1, E280A mutation carriers, for early-onset Alzheimer's disease.
9 March 2023
Researchers from Rowan University and Durin Technologies announce highly accurate blood test for Alzheimer’s Disease
A team of researchers from Rowan-Virtua School of Osteopathic Medicine (Rowan-Virtua SOM) and Durin Technologies, Inc., have announced the results of a newly-designed blood test that can detect the presence of Alzheimer’s disease-related pathology up to 10 years before symptoms arise with a nearly 97 percent accuracy rate. Their findings appear online ahead of press in the Journal of Alzheimer’s Disease.
9 March 2023
New Cleveland Clinic-Developed Screening Tool Can Assess Cognition Issues in Older Adults
A self-administered screening tool, developed by Cleveland Clinic researchers, can effectively and efficiently assess cognition issues in older adults. A new study found that the simple test taken on a tablet computer before an annual physical is conducive to use in a primary care setting for detecting mild cognitive impairment, early Alzheimer’s disease, and other related dementias. Results were published in Journal of Alzheimer’s Disease.
10 February 2023
In patients with mild cognitive impairment, apathy can be a predictor of Alzheimer’s disease
The presence of apathy in patients with mild cognitive impairment is strongly linked to a progression to Alzheimer’s disease, giving physicians a possible early diagnosis tool, according to UTHealth Houston research published recently in the Journal of Alzheimer’s Disease.
6 February 2023
Do Sleep Medications Increase Your Chances of Dementia?
A new study shows that sleep medications increase the risk of dementia in whites. But the type and quantity of the medication may be factors in explaining the higher risk. It follows previous work that shows Blacks have a higher likelihood than whites of developing Alzheimer’s, the most common type of dementia, and that they have different risk factors and disease manifestation.
6 February 2023
Study finds obesity-related neurodegeneration mimics Alzheimer’s disease
A new study led by scientists at The Neuro (Montreal Neurological Institute-Hospital) of McGill University finds a correlation between neurodegeneration in obese people and Alzheimer’s disease (AD) patients. Previous research has shown that obesity is linked with Alzheimer’s disease (AD)-related changes, such as cerebrovascular damage and amyloid-β accumulation. However, to date no research has made a direct comparison between brain atrophy patterns in AD and obesity.
24 January 2023
Exposure to World Trade Center Dust Exacerbates Cognitive Impairment in an Animal Model of Alzheimer’s
Mice exposed to World Trade Center dust exhibit a significant impairment in spatial recognition and short- and long-term memory, as well as changes in genes related to immune-inflammatory responses and blood-brain barrier disruption, according to a study conducted by researchers from the Icahn School of Medicine at Mount Sinai and published January 17 in the Journal of Alzheimer’s Disease.