25 October 2018
UC San Francisco researchers, in collaboration with the unique Brazilian Biobank for Aging Studies (BBAS) at the University of São Paulo, have shown that the earliest stages of the brain degeneration associated with Alzheimer’s disease (AD) are linked to neuropsychiatric symptoms including anxiety, depression, loss of appetite, and sleep disturbances.
22 October 2018
For older adults, it may seem as though the die is already cast regarding their odds of developing dementia, but new research from the University of Pittsburgh has identified a dementia risk factor among older adults that should be modifiable even well into old age. The study, which draws on data collected from following hundreds of elderly Pittsburghers for more than 15 years, was published today in JAD.
19 October 2018
A hypothesis which has been the standard way of explaining how the body develops Alzheimer’s Disease for almost 30 years is flawed, according to a University of Manchester biologist. The ‘Amyloid Cascade’ argues that a series of stages, starting from the deposition of a starch-like protein called amyloid and ending with dementia, should be reassessed. Prof Andrew Doig’s review of 120 scientific papers finds that the stages were not linked together in a cascade and the progression to dementia was not linear.
12 October 2018
A New Study Indicates Measuring the Progression of Alzheimer’s Disease by Monitoring Major Brain Antioxidant Levels Using Non-Invasive Techniques
In a breakthrough human study published in JAD, anti-oxidant glutathione (GSH), which protects the brain from stress, has been found to be significantly depleted in Alzheimer's patients compared to normal subjects. As GSH is a very important anti-oxidant that protects the brain from free radicals, the findings give us another measure to use when diagnosing potential for the advancement of Alzheimer’s disease or recognizing those that are in the throes of Alzheimer’s advancement.
14 September 2018
Can a Novel High-Density EEG Approach Disentangle the Differences of Visual Event Related Potential (N170) in People with Subjective Cognitive Impairment?
Greek researchers investigated whether specific brain regions, which have been found to be highly activated after negative facial stimulus, are also activated in different groups of people with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) compared to healthy controls (HC).
1 September 2018
Every year in September across the globe, efforts are made to increase awareness of AD and dementia – and the ongoing research into the disease – during World Alzheimer's Month. Join our commmunity in spreading awareness of the impact JAD has, and what our journal achieves in terms of advancing knowledge in the field, and you could be enter a draw to win a copy of our latest book! Read more
23 August 2018
To keep our JAD editors, authors, and readers informed of JAD's progress and development, the journal hereby shares the 2018 editorial update.
21 August 2018
In the largest known brain imaging study, scientists from Amen Clinics (Costa Mesa, CA), Google, John’s Hopkins University, University of California, Los Angeles and the University of California, San Francisco evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging. SPECT tomography) evaluates regional cerebral blood flow in the brain that is reduced in various disorders.
20 August 2018
Impact of Osteoporosis on the Risk of Dementia in Almost 60,000 Patients Followed in General Practices in Germany
Osteoporosis is estimated to affect 200 million women across the world. In Germany, the prevalence of this chronic disease among people aged 50 years and older is around 15%. In recent decades, several authors have analyzed the impact of osteoporosis on the risk of cognitive decline, but, most of these studies have been conducted outside Europe. The goal of the present study was to investigate the impact of osteoporosis on the risk of developing dementia in almost 60,000 patients followed for up to 20 years in more than 1,200 general practices in Germany.
26 July 2018
Driving is a complex task that involves perceptual, motor and cognitive abilities. These abilities may be affected in early Alzheimer Disease (AD) patients. Nevertheless, they continue to drive for more years than people with other dementia syndromes perhaps because of a deficit in self-awareness that prevents them from perceiving their driving difficulties and adapting accordingly. The purpose of the present pilot study was to closely examine the self-regulation behavior of older individuals with AD using a naturalistic driving approach.