Journal of Alzheimer's Disease
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Home > Molecular Basis of Alzheimer's Disease: Focus on Mitochondria.

TitleMolecular Basis of Alzheimer's Disease: Focus on Mitochondria.
Publication TypeJournal Article
Year of Publication2019
AuthorsOliver, DMA, P Reddy, H
JournalJ Alzheimers Dis
Volume72
Issues1
PaginationS95-S116
Date Published2019
ISSN1875-8908
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by memory loss and multiple cognitive impairments. With the increased aging population, AD is a major health concern in society. Morphological and pathological studies revealed that AD is associated with the loss of synapses, defective mitochondria, and the proliferation of reactive astrocytes and microglia, in addition to the presence amyloid-β and phosphorylated tau in learning and memory regions of the brain in AD patients. AD occurs in two forms: early-onset familial and late-onset sporadic. Genetic mutations in APP, PS1, and PS2 loci cause familial AD. Multiple factors are reported to be involved in late-onset AD, including APOE4 genotype, polymorphisms in several gene loci and type 2 diabetes, traumatic brain injury, stroke, and age-related factors, including increased reactive oxygen species production and dysfunction in mitochondria. It is widely accepted that synaptic damage and mitochondrial dysfunction are early events in disease process. The purpose of this article is to highlight molecular triggers to the disease process. This article also reviews factors, including age, gender, lifestyle, epigenetic factors, and type 2 diabetes, that are involved in late-onset AD. This article also discusses recent developments in research of mitochondrial structure, function, physiology, dynamics, biogenesis, mitophagy, and mitochondrial DNA changes in healthy and diseased states.

DOI10.3233/JAD-190048
Alternate JournalJ. Alzheimers Dis.
PubMed ID30932888
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Source URL: https://www.j-alz.com/content/molecular-basis-alzheimers-disease-focus-mitochondria