Neuropsychiatric symptoms of Alzheimer’s disease in Down syndrome and its impact on caregiver distress Manuscript Number: 20-1009R3 Author(s): Cassio Machado Bottino, Ekaterina Burduli, Geraldo Busatto, Naomi Sage Chaytor, Luciana Mascarenhas Fonseca, Laura Maria de Figueiredo Ferreira Guilhoto, Glenda Guerra Haddad, Marcelo Queiroz Hoexter, Guilherme Prado Mattar, Sterling M. McPherson, Monica Sanches Yassuda