Title | ANMerge: A Comprehensive and Accessible Alzheimer's Disease Patient-Level Dataset. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Birkenbihl, C, Westwood, S, Shi, L, Nevado-Holgado, A, Westman, E, Lovestone, S, Hofmann-Apitius, M |
Corporate Authors | AddNeuroMed Consortium |
Journal | J Alzheimers Dis |
Volume | 79 |
Issue | 1 |
Pagination | 423-431 |
Date Published | 2021 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Cohort Studies, Datasets as Topic, Female, Gene Expression Profiling, Genotype, Humans, Magnetic Resonance Imaging, Male, Proteomics |
Abstract | BACKGROUND: Accessible datasets are of fundamental importance to the advancement of Alzheimer's disease (AD) research. The AddNeuroMed consortium conducted a longitudinal observational cohort study with the aim to discover AD biomarkers. During this study, a broad selection of data modalities was measured including clinical assessments, magnetic resonance imaging, genotyping, transcriptomic profiling, and blood plasma proteomics. Some of the collected data were shared with third-party researchers. However, this data was incomplete, erroneous, and lacking in interoperability. OBJECTIVE: To provide the research community with an accessible, multimodal, patient-level AD cohort dataset. METHODS: We systematically addressed several limitations of the originally shared resources and provided additional unreleased data to enhance the dataset. RESULTS: In this work, we publish and describe ANMerge, a new version of the AddNeuroMed dataset. ANMerge includes multimodal data from 1,702 study participants and is accessible to the research community via a centralized portal. CONCLUSION: ANMerge is an information rich patient-level data resource that can serve as a discovery and validation cohort for data-driven AD research, such as, for example, machine learning and artificial intelligence approaches. |
DOI | 10.3233/JAD-200948 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 33285634 |
PubMed Central ID | PMC7902946 |
Grant List | MC_PC_17215 / MRC_ / Medical Research Council / United Kingdom / / Department of Health (NIHR) / |