| Title | Plasma Biomarkers of Alzheimer's Disease in African Americans. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Deniz, K, Ho, CCG, Malphrus, KG, Reddy, JS, Nguyen, T, Carnwath, TP, Crook, JE, Lucas, JA, Graff-Radford, NR, Carrasquillo, MM, Ertekin-Taner, N |
| Journal | J Alzheimers Dis |
| Volume | 79 |
| Issue | 1 |
| Pagination | 323-334 |
| Date Published | 2021 |
| ISSN | 1875-8908 |
| Keywords | African Americans, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Apolipoproteins E, Case-Control Studies, Female, Humans, Interleukin-10, Interleukin-6, Male, Middle Aged, Peptide Fragments, tau Proteins, Tumor Necrosis Factor-alpha |
| Abstract | BACKGROUND/OBJECTIVE: The aim of this study was to determine if plasma concentrations of 5 surrogate markers of Alzheimer's disease (AD) pathology and neuroinflammation are associated with disease status in African Americans. METHODS: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida Consortium for African-American Alzheimer's Disease Studies (FCA3DS). Five plasma proteins reflecting AD neuropathology or inflammation (Aβ42, tau, IL6, IL10, TNFα) were tested for associations with AD, age, sex, APOE and MAPT genotypes, and for pairwise correlations. RESULTS: Plasma tau levels were higher in AD when adjusted for biological and technical covariates. APOEɛ4 was associated with lower plasma Aβ42 and tau levels. Older age was associated with higher plasma Aβ42, tau, and TNFα. Females had lower IL10 levels. Inflammatory proteins had strong pairwise correlations amongst themselves and with Aβ42. CONCLUSION: We identified effects of demographic and genetic variants on five potential plasma biomarkers in African Americans. Plasma inflammatory biomarkers and Aβ42 may reflect correlated pathologies and elevated plasma tau may be a biomarker of AD in this population. |
| DOI | 10.3233/JAD-200828 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 33252078 |
| PubMed Central ID | PMC7902984 |
| Grant List | P30 AG062677 / AG / NIA NIH HHS / United States R01 AG061796 / AG / NIA NIH HHS / United States RF1 AG051504 / AG / NIA NIH HHS / United States U01 AG046139 / AG / NIA NIH HHS / United States |
