| Title | Incremental Healthcare Utilization and Cost Burden of Comorbid Insomnia in Alzheimer's Disease Patients. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Qureshi, ZP, Thiel, E, Nelson, J, Khandker, R |
| Journal | J Alzheimers Dis |
| Volume | 83 |
| Issue | 4 |
| Pagination | 1679-1690 |
| Date Published | 2021 |
| ISSN | 1875-8908 |
| Keywords | Aged, 80 and over, Alzheimer Disease, Comorbidity, Databases, Factual, Female, Health Care Costs, Humans, Male, Medicare, Patient Acceptance of Health Care, Retrospective Studies, Sleep Initiation and Maintenance Disorders, United States |
| Abstract | BACKGROUND: Insomnia is associated with worsened clinical outcomes among Alzheimer's disease dementia (AD) patients, increased caregiver burden, and healthcare utilization. OBJECTIVE: This study aimed to characterize the incremental healthcare burden of insomnia in AD using real-world data. METHODS: A retrospective observational study was conducted on AD patients selected from the IBM® MarketScan Commercial and Medicare Supplemental Databases. AD patients with claims-based evidence of insomnia were direct matched to a non-insomnia cohort based on demographic factors. Healthcare utilization and associated costs were assessed for a 12-month follow-up period. RESULTS: A total of 3,500 insomnia AD patients and 9,884 non-insomnia AD patients were analyzed. The insomnia cohort had a higher comorbidity burden at baseline (mean score on Charlson Comorbidity Index 2.5 versus 2.2, p CONCLUSION: AD patients with comorbid insomnia are more likely to use higher-cost healthcare services such as inpatient hospitalization, and skilled nursing, and have higher total healthcare costs. This real-world analysis provides evidence that AD disease management should consider proper treatment of comorbid insomnia due to the incremental burden and cost implications. |
| DOI | 10.3233/JAD-210713 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 34420974 |
| PubMed Central ID | PMC8609711 |
